Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3IEM

Crystal Structure of TTHA0252 from Thermus thermophilus HB8 complexed with RNA analog

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004521	molecular_function	RNA endonuclease activity
A	0005737	cellular_component	cytoplasm
A	0006364	biological_process	rRNA processing
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0003723	molecular_function	RNA binding
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0004521	molecular_function	RNA endonuclease activity
B	0005737	cellular_component	cytoplasm
B	0006364	biological_process	rRNA processing
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
C	0003723	molecular_function	RNA binding
C	0004518	molecular_function	nuclease activity
C	0004519	molecular_function	endonuclease activity
C	0004521	molecular_function	RNA endonuclease activity
C	0005737	cellular_component	cytoplasm
C	0006364	biological_process	rRNA processing
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
D	0003723	molecular_function	RNA binding
D	0004518	molecular_function	nuclease activity
D	0004519	molecular_function	endonuclease activity
D	0004521	molecular_function	RNA endonuclease activity
D	0005737	cellular_component	cytoplasm
D	0006364	biological_process	rRNA processing
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 432

Chain	Residue
A	ARG241
A	HOH521
B	SER330
B	ASP331

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 433

Chain	Residue
A	ARG192
A	ARG195
A	GLY375
A	HOH491
A	HOH529

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 434

Chain	Residue
A	LYS298
A	HIS323
A	LYS326
A	HIS327

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 435

Chain	Residue
A	ARG198
A	GLU199
A	ARG202

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 436

Chain	Residue
A	ARG77
A	GLU113
A	HIS117

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 437

Chain	Residue
A	PRO172
A	ASP173
A	SER269
A	GLU270
A	HOH490
A	HOH500

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 438

Chain	Residue
A	ARG24
A	LEU129
A	GLY130
A	HOH507

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 439

Chain	Residue
A	PRO304
A	ASP331
A	ARG333

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 440

Chain	Residue
A	ARG195
A	GLU199
D	LYS326
D	HIS327
D	SER330

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 441

Chain	Residue
A	HIS61
A	LEU142
A	PHE223
A	VAL225
A	GLU226
A	ARG227
G	SSU4
G	HOH97

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 442

Chain	Residue
A	ARG202
A	HIS238
A	HIS240
A	ARG241
B	PRO366
B	ARG368

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 443

Chain	Residue
A	PRO252
A	MET253
A	ARG256
G	SSU6

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 444

Chain	Residue
A	HIS293
A	THR294
A	GLU295
G	SSU6

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 445

Chain	Residue
A	ARG368

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 446

Chain	Residue
A	TYR248
A	GLU289
A	ALA296
B	TYR248
B	GLU289
B	HOH496

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 447

Chain	Residue
A	MET1
A	ARG2
A	HOH498

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 448

Chain	Residue
A	ASP63
A	HIS64
A	ASP162
A	HIS400
A	ZN449
G	SSU3

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 449

Chain	Residue
A	HIS59
A	HIS61
A	HIS141
A	ASP162
A	ZN448
G	SSU3

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 432

Chain	Residue
B	PRO243
B	ARG244

site_id	CC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 B 433

Chain	Residue
B	ARG24

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 434

Chain	Residue
B	ARG84
B	ARG263

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 435

Chain	Residue
B	ARG354
B	SO4448

site_id	CC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 436

Chain	Residue
B	TYR189
B	ARG227
B	GLY340
B	TYR341
B	SER378
B	GLY379
K	SSU1

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 437

Chain	Residue
B	LEU387
B	LEU412

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 438

Chain	Residue
B	GLY130
B	ARG24
B	LEU129

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 439

Chain	Residue
B	ARG195
B	GLY375
B	GLY376
B	HOH500

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 440

Chain	Residue
B	HIS372
B	THR373
B	SO4441

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 441

Chain	Residue
B	ILE352
B	ARG354
B	VAL371
B	SO4440
B	SO4448

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 442

Chain	Residue
B	PRO172
B	ASP173
B	SER269
B	GLU270

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 443

Chain	Residue
B	SER370
B	HIS372
B	SO4448

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 444

Chain	Residue
B	ARG320
B	HOH517
K	HOH524

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 445

Chain	Residue
B	HIS293
B	THR294
B	GLU295
B	HOH517
L	SSU2

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 446

Chain	Residue
B	ARG359
B	LEU361
B	HOH464

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 447

Chain	Residue
A	ARG244
A	ARG244
B	LYS298
B	LYS298

site_id	DC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 448

Chain	Residue
B	ARG354
B	ALA369
B	SER370
B	VAL371
B	SO4435
B	SO4441
B	SO4443

site_id	DC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 449

Chain	Residue
A	ARG244
B	HIS323
B	LYS326
B	HIS327

site_id	EC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FLC B 450

Chain	Residue
A	LEU407
A	GLY410
A	LYS411
B	LEU407
B	GLY410
B	LYS411

site_id	EC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN B 451

Chain	Residue
B	ASP63
B	HIS64
B	ASP162
B	HIS400
B	ZN452
K	SSU1

site_id	EC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN B 452

Chain	Residue
B	HIS59
B	HIS61
B	HIS141
B	ASP162
B	ZN451
K	SSU1

site_id	EC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 432

Chain	Residue
C	VAL291
C	GLU292
C	HIS293

site_id	EC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 C 433

Chain	Residue
C	ARG354

site_id	EC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 434

Chain	Residue
C	ARG24
C	LEU129
C	GLY130

site_id	EC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 435

Chain	Residue
C	ARG84
C	LEU88
C	ARG263
C	ARG266

site_id	EC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 C 436

Chain	Residue
C	ARG155

site_id	EC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 437

Chain	Residue
C	ARG10
C	ARG424

site_id	FC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 438

Chain	Residue
A	ARG73
C	ARG424

site_id	FC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 439

Chain	Residue
C	LEU171
C	PRO172
C	ASP173
C	SER269
C	GLU270

site_id	FC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 440

Chain	Residue
C	GLU153
C	HOH461

site_id	FC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 441

Chain	Residue
C	HIS42
C	PRO104
C	PHE105

site_id	FC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 442

Chain	Residue
C	TYR189
C	ARG227
C	GLY340
C	TYR341
C	SER378
C	GLY379
P	SSU1

site_id	FC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 443

Chain	Residue
A	ARG73
C	ARG424

site_id	FC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 444

Chain	Residue
C	ASP63
C	HIS64
C	ASP162
C	HIS400
C	ZN445

site_id	FC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 445

Chain	Residue
C	HIS59
C	HIS61
C	HIS141
C	ASP162
C	ZN444

site_id	FC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 D 432

Chain	Residue
D	ARG263

site_id	GC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 433

Chain	Residue
D	PRO366
D	ARG368

site_id	GC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 435

Chain	Residue
D	ARG24
D	ARG128
D	LEU129
D	GLY130

site_id	GC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 436

Chain	Residue
A	ARG84
A	PRO120
A	GLU122
A	ARG266
D	GLU270
D	HOH446

site_id	GC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 D 437

Chain	Residue
D	ARG155

site_id	GC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 438

Chain	Residue
D	PRO172
D	ASP173
D	SER269
D	GLU270
D	HOH467

site_id	GC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 439

Chain	Residue
D	LYS298
D	HIS323
D	LYS326
D	HIS327

site_id	GC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 440

Chain	Residue
D	HIS42
D	PHE105
D	HOH461

site_id	GC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 441

Chain	Residue
D	MET1
D	ARG2

site_id	GC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 442

Chain	Residue
D	ARG77
D	GLU113
D	HIS117

site_id	HC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN D 443

Chain	Residue
D	ASP63
D	HIS64
D	ASP162
D	HIS400
D	ZN444
I	SSU3

site_id	HC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN D 444

Chain	Residue
D	HIS59
D	HIS61
D	HIS141
D	ASP162
D	ZN443
I	SSU3

site_id	HC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 J 40

Chain	Residue
J	SSU3

site_id	HC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 K 36

Chain	Residue
K	SSU3
K	HOH227
K	HOH524

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Binding site: {}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)