3ICQ

Karyopherin nuclear state

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0006913	biological_process	nucleocytoplasmic transport
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
C	0006913	biological_process	nucleocytoplasmic transport
T	0000049	molecular_function	tRNA binding
T	0003723	molecular_function	RNA binding
T	0005049	molecular_function	nuclear export signal receptor activity
T	0005515	molecular_function	protein binding
T	0005525	molecular_function	GTP binding
T	0005634	cellular_component	nucleus
T	0005635	cellular_component	nuclear envelope
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0006409	biological_process	tRNA export from nucleus
T	0008033	biological_process	tRNA processing
T	0016363	cellular_component	nuclear matrix
T	0031267	molecular_function	small GTPase binding
T	0071528	biological_process	tRNA re-export from nucleus
U	0000049	molecular_function	tRNA binding
U	0003723	molecular_function	RNA binding
U	0005049	molecular_function	nuclear export signal receptor activity
U	0005515	molecular_function	protein binding
U	0005525	molecular_function	GTP binding
U	0005634	cellular_component	nucleus
U	0005635	cellular_component	nuclear envelope
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0006409	biological_process	tRNA export from nucleus
U	0008033	biological_process	tRNA processing
U	0016363	cellular_component	nuclear matrix
U	0031267	molecular_function	small GTPase binding
U	0071528	biological_process	tRNA re-export from nucleus

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	BINDING SITE FOR RESIDUE GTP B 250

Chain	Residue
B	HOH1
B	PHE37
B	GLU38
B	LYS39
B	LYS40
B	TYR41
B	ILE42
B	ALA43
B	THR44
B	THR68
B	ALA69
B	MG2
B	GLY70
B	ASN124
B	LYS125
B	ASP127
B	SER152
B	ALA153
B	LYS154
T	THR798
T	ASP799
B	HOH3
B	GLY21
B	GLY22
B	GLY24
B	LYS25
B	THR26
B	THR27

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 2

Chain	Residue
B	THR26
B	THR44
B	ASP67
B	GTP250

---

site_id	AC3
Number of Residues	27
Details	BINDING SITE FOR RESIDUE GTP C 250

Chain	Residue
C	HOH4
C	MG5
C	HOH6
C	GLY21
C	GLY22
C	GLY24
C	LYS25
C	THR26
C	THR27
C	GLU38
C	LYS39
C	LYS40
C	TYR41
C	ILE42
C	ALA43
C	THR44
C	THR68
C	GLY70
C	ASN124
C	LYS125
C	ASP127
C	SER152
C	ALA153
C	LYS154
U	GLY797
U	THR798
U	ASP799

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 5

Chain	Residue
C	THR26
C	THR44
C	ASP67
C	GTP250

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Region: {"description":"Switch-I","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Region: {"description":"Switch-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	26
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P62825","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	LEU71

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	LEU71

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	GLY22

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	GLY22

---