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3IBG

Crystal structure of Aspergillus fumigatus Get3 with bound ADP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000750biological_processpheromone-dependent signal transduction involved in conjugation with cellular fusion
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0006457biological_processprotein folding
A0006620biological_processpost-translational protein targeting to endoplasmic reticulum membrane
A0006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
A0009408biological_processresponse to heat
A0010038biological_processresponse to metal ion
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0042802molecular_functionidentical protein binding
A0043529cellular_componentGET complex
A0044183molecular_functionprotein folding chaperone
A0045048biological_processprotein insertion into ER membrane
A0046872molecular_functionmetal ion binding
A0051082molecular_functionunfolded protein binding
A0071816biological_processtail-anchored membrane protein insertion into ER membrane
B0000166molecular_functionnucleotide binding
B0000750biological_processpheromone-dependent signal transduction involved in conjugation with cellular fusion
B0005085molecular_functionguanyl-nucleotide exchange factor activity
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0006457biological_processprotein folding
B0006620biological_processpost-translational protein targeting to endoplasmic reticulum membrane
B0006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
B0009408biological_processresponse to heat
B0010038biological_processresponse to metal ion
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0042802molecular_functionidentical protein binding
B0043529cellular_componentGET complex
B0044183molecular_functionprotein folding chaperone
B0045048biological_processprotein insertion into ER membrane
B0046872molecular_functionmetal ion binding
B0051082molecular_functionunfolded protein binding
B0071816biological_processtail-anchored membrane protein insertion into ER membrane
C0000166molecular_functionnucleotide binding
C0000750biological_processpheromone-dependent signal transduction involved in conjugation with cellular fusion
C0005085molecular_functionguanyl-nucleotide exchange factor activity
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0006457biological_processprotein folding
C0006620biological_processpost-translational protein targeting to endoplasmic reticulum membrane
C0006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
C0009408biological_processresponse to heat
C0010038biological_processresponse to metal ion
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0042802molecular_functionidentical protein binding
C0043529cellular_componentGET complex
C0044183molecular_functionprotein folding chaperone
C0045048biological_processprotein insertion into ER membrane
C0046872molecular_functionmetal ion binding
C0051082molecular_functionunfolded protein binding
C0071816biological_processtail-anchored membrane protein insertion into ER membrane
D0000166molecular_functionnucleotide binding
D0000750biological_processpheromone-dependent signal transduction involved in conjugation with cellular fusion
D0005085molecular_functionguanyl-nucleotide exchange factor activity
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0006457biological_processprotein folding
D0006620biological_processpost-translational protein targeting to endoplasmic reticulum membrane
D0006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
D0009408biological_processresponse to heat
D0010038biological_processresponse to metal ion
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0042802molecular_functionidentical protein binding
D0043529cellular_componentGET complex
D0044183molecular_functionprotein folding chaperone
D0045048biological_processprotein insertion into ER membrane
D0046872molecular_functionmetal ion binding
D0051082molecular_functionunfolded protein binding
D0071816biological_processtail-anchored membrane protein insertion into ER membrane
E0000166molecular_functionnucleotide binding
E0000750biological_processpheromone-dependent signal transduction involved in conjugation with cellular fusion
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005783cellular_componentendoplasmic reticulum
E0006457biological_processprotein folding
E0006620biological_processpost-translational protein targeting to endoplasmic reticulum membrane
E0006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
E0009408biological_processresponse to heat
E0010038biological_processresponse to metal ion
E0016787molecular_functionhydrolase activity
E0016887molecular_functionATP hydrolysis activity
E0042802molecular_functionidentical protein binding
E0043529cellular_componentGET complex
E0044183molecular_functionprotein folding chaperone
E0045048biological_processprotein insertion into ER membrane
E0046872molecular_functionmetal ion binding
E0051082molecular_functionunfolded protein binding
E0071816biological_processtail-anchored membrane protein insertion into ER membrane
F0000166molecular_functionnucleotide binding
F0000750biological_processpheromone-dependent signal transduction involved in conjugation with cellular fusion
F0005085molecular_functionguanyl-nucleotide exchange factor activity
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005783cellular_componentendoplasmic reticulum
F0006457biological_processprotein folding
F0006620biological_processpost-translational protein targeting to endoplasmic reticulum membrane
F0006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
F0009408biological_processresponse to heat
F0010038biological_processresponse to metal ion
F0016787molecular_functionhydrolase activity
F0016887molecular_functionATP hydrolysis activity
F0042802molecular_functionidentical protein binding
F0043529cellular_componentGET complex
F0044183molecular_functionprotein folding chaperone
F0045048biological_processprotein insertion into ER membrane
F0046872molecular_functionmetal ion binding
F0051082molecular_functionunfolded protein binding
F0071816biological_processtail-anchored membrane protein insertion into ER membrane
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE ADP A 349
ChainResidue
AGLY36
AVAL319
AARG320
APHE328
FARG200
AGLY38
ALYS39
ATHR40
ATHR41
AASN67
AASN272
APRO313
ALEU315

site_idAC2
Number of Residues15
DetailsBINDING SITE FOR RESIDUE ADP B 349
ChainResidue
BGLY36
BVAL37
BGLY38
BLYS39
BTHR40
BTHR41
BASN67
BASN272
BPRO313
BLEU314
BLEU315
BVAL319
BARG320
BPHE328
CARG200

site_idAC3
Number of Residues16
DetailsBINDING SITE FOR RESIDUE ADP C 349
ChainResidue
BARG200
CGLY36
CVAL37
CGLY38
CLYS39
CTHR40
CTHR41
CASN67
CASN272
CPRO313
CLEU314
CLEU315
CGLU318
CVAL319
CARG320
CPHE328

site_idAC4
Number of Residues16
DetailsBINDING SITE FOR RESIDUE ADP D 349
ChainResidue
DGLY36
DVAL37
DGLY38
DLYS39
DTHR40
DTHR41
DASN67
DASN272
DPRO313
DLEU314
DLEU315
DGLU318
DVAL319
DARG320
DPHE328
EARG200

site_idAC5
Number of Residues14
DetailsBINDING SITE FOR RESIDUE ADP E 349
ChainResidue
DARG200
EGLY36
EGLY38
ELYS39
ETHR40
ETHR41
EASN67
EASN272
EPRO313
ELEU314
ELEU315
EVAL319
EARG320
EPHE328

site_idAC6
Number of Residues15
DetailsBINDING SITE FOR RESIDUE ADP F 349
ChainResidue
AARG200
FGLY36
FVAL37
FGLY38
FLYS39
FTHR40
FTHR41
FASN67
FASN272
FPRO313
FLEU315
FGLU318
FVAL319
FARG320
FPHE328

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_03112
ChainResidueDetails
AASP63
BASP63
CASP63
DASP63
EASP63
FASP63

site_idSWS_FT_FI2
Number of Residues18
DetailsBINDING:
ChainResidueDetails
ALYS34
DLYS34
DASN272
DARG320
ELYS34
EASN272
EARG320
FLYS34
FASN272
FARG320
AASN272
AARG320
BLYS34
BASN272
BARG320
CLYS34
CASN272
CARG320

site_idSWS_FT_FI3
Number of Residues18
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03112
ChainResidueDetails
AGLU245
DGLU245
DCYS283
DCYS286
EGLU245
ECYS283
ECYS286
FGLU245
FCYS283
FCYS286
ACYS283
ACYS286
BGLU245
BCYS283
BCYS286
CGLU245
CCYS283
CCYS286

218853

PDB entries from 2024-04-24

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