3IA5
Moritella profunda dihydrofolate reductase (DHFR)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0044281 | biological_process | small molecule metabolic process |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| A | 0070401 | molecular_function | NADP+ binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004146 | molecular_function | dihydrofolate reductase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0044281 | biological_process | small molecule metabolic process |
| B | 0046452 | biological_process | dihydrofolate metabolic process |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046655 | biological_process | folic acid metabolic process |
| B | 0050661 | molecular_function | NADP binding |
| B | 0070401 | molecular_function | NADP+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 163 |
| Chain | Residue |
| A | GLY44 |
| A | ARG45 |
| A | ASN46 |
| A | THR47 |
| A | GLY98 |
| A | ILE101 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 B 163 |
| Chain | Residue |
| B | THR47 |
| B | GLY98 |
| B | ILE101 |
| B | HOH174 |
| B | GLY44 |
| B | ARG45 |
| B | ASN46 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 164 |
| Chain | Residue |
| A | TRP23 |
| A | HIS24 |
| A | HIS151 |
| B | ASN134 |
| B | TRP135 |
| B | HOH256 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGldnkMPWhlpa.ElqlFkraT |
| Chain | Residue | Details |
| A | VAL14-THR36 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 7 |
| Details | Annotated By Reference To The Literature 1ra2 |
| Chain | Residue | Details |
| A | ILE6 | |
| A | GLU28 | |
| A | MET21 | |
| A | PHE32 | |
| A | ILE96 | |
| A | LEU55 | |
| A | LEU29 |
| site_id | CSA2 |
| Number of Residues | 7 |
| Details | Annotated By Reference To The Literature 1ra2 |
| Chain | Residue | Details |
| B | ILE6 | |
| B | GLU28 | |
| B | MET21 | |
| B | PHE32 | |
| B | ILE96 | |
| B | LEU55 | |
| B | LEU29 |
