3I93

Crystal structure of Mycobacterium tuberculosis dUTPase STOP138T mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004170	molecular_function	dUTP diphosphatase activity
A	0006220	biological_process	pyrimidine nucleotide metabolic process
A	0006226	biological_process	dUMP biosynthetic process
A	0009117	biological_process	nucleotide metabolic process
A	0016787	molecular_function	hydrolase activity
A	0046080	biological_process	dUTP metabolic process
A	0046081	biological_process	dUTP catabolic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 200

Chain	Residue
A	DUP201
A	HOH383
A	HOH384
A	HOH395

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site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE DUP A 201

Chain	Residue
A	THR81
A	ILE82
A	ASP83
A	TYR86
A	GLU89
A	ILE90
A	LYS91
A	GLN113
A	MG200
A	HOH323
A	HOH324
A	HOH353
A	HOH355
A	HOH383
A	HOH384
A	HOH395
A	ARG64
A	SER65
A	GLY66
A	ASN77
A	GLY80

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE TRS A 202

Chain	Residue
A	SER74
A	SER74
A	ILE75
A	VAL76
A	HOH309
A	HOH309

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site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TRS A 203

Chain	Residue
A	ARG9
A	ARG9
A	PRO12
A	PRO12
A	PRO12
A	HOH356
A	HOH389
A	HOH389

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00116, ECO:0000269|PubMed:15276840

Chain	Residue	Details
A	ARG64
A	ASN77
A	THR81

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:15276840

Chain	Residue	Details
A	LYS91

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
A	GLY85
A	ASP83

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