3I8R

Crystal structure of the heme oxygenase from Corynebacterium diphtheriae (HmuO) in complex with heme binding ditiothreitol (DTT)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004392	molecular_function	heme oxygenase (decyclizing) activity
A	0006788	biological_process	heme oxidation
A	0006979	biological_process	response to oxidative stress
A	0016491	molecular_function	oxidoreductase activity
A	0020037	molecular_function	heme binding
A	0042167	biological_process	heme catabolic process
A	0046872	molecular_function	metal ion binding
B	0004392	molecular_function	heme oxygenase (decyclizing) activity
B	0006788	biological_process	heme oxidation
B	0006979	biological_process	response to oxidative stress
B	0016491	molecular_function	oxidoreductase activity
B	0020037	molecular_function	heme binding
B	0042167	biological_process	heme catabolic process
B	0046872	molecular_function	metal ion binding
C	0004392	molecular_function	heme oxygenase (decyclizing) activity
C	0006788	biological_process	heme oxidation
C	0006979	biological_process	response to oxidative stress
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0042167	biological_process	heme catabolic process
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM A 901

Chain	Residue
A	LYS13
A	PHE201
A	ASN204
A	PHE208
A	HOH235
A	HOH361
A	HOH419
A	DTV2001
A	HIS20
A	ALA23
A	MET29
A	TYR130
A	VAL131
A	GLY135
A	VAL142
A	ARG177

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1001

Chain	Residue
A	SER26
A	THR27
A	HIS205
A	HOH279
A	HOH286

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1005

Chain	Residue
A	ARG99
A	ILE100
A	THR101

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DTV A 2001

Chain	Residue
A	ARG132
A	GLY135
A	ASP136
A	GLY139
A	GLY140
A	HOH326
A	HEM901

---

site_id	AC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEM B 902

Chain	Residue
B	HOH25
B	HOH185
B	LYS313
B	HIS320
B	ALA323
B	MET329
B	LEU333
B	TYR430
B	VAL431
B	GLY435
B	SER438
B	GLY439
B	ARG477
B	PHE501
B	ASN504
B	PHE508
B	DTV2002

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1002

Chain	Residue
B	HOH18
B	VAL382
B	ARG385
B	GLY459
B	HOH532

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1003

Chain	Residue
B	HOH67
B	HOH289
B	LYS470
B	LYS473
B	ARG477

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1004

Chain	Residue
B	HOH196
B	SER326
B	THR327
B	HIS505
B	ALA509

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 1008

Chain	Residue
B	HOH61
B	HOH213
B	GLY367
B	ALA369
B	GLU370
B	SER371
B	HOH516

---

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE DTV B 2002

Chain	Residue
B	HOH3
B	HOH5
B	HOH130
B	MET329
B	ARG432
B	GLY435
B	GLY439
B	ILE443
B	PHE508
B	HEM902

---

site_id	BC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM C 903

Chain	Residue
C	HOH158
C	HOH226
C	LYS613
C	HIS620
C	ALA623
C	GLU624
C	TYR730
C	VAL731
C	LEU734
C	GLY735
C	SER738
C	GLY739
C	VAL742
C	ILE743
C	ARG777
C	PHE801
C	ASN804
C	PHE808
C	DTV2003

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 1009

Chain	Residue
C	SER626
C	THR627
C	PHE628
C	HIS805
C	ALA809

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 1010

Chain	Residue
C	HOH212
C	HOH356
C	GLY667
C	ALA669
C	GLU670
C	SER671

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 1011

Chain	Residue
C	HOH403
C	VAL682
C	ARG685
C	GLY759

---

site_id	BC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE DTV C 2003

Chain	Residue
C	HOH118
C	HOH202
C	HOH346
C	MET629
C	ARG732
C	GLY735
C	ASP736
C	GLY739
C	PHE808
C	HEM903

---

Functional Information from PROSITE/UniProt

site_id	PS00593
Number of Residues	11
Details	HEME_OXYGENASE Heme oxygenase signature. LVAHHYVRYLG

Chain	Residue	Details
A	LEU125-GLY135

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