3I4X
Crystal structure of the dimethylallyl tryptophan synthase FgaPT2 from Aspergillus fumigatus in complex with Trp and DMSPP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0009820 | biological_process | alkaloid metabolic process |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0035835 | biological_process | indole alkaloid biosynthetic process |
| A | 0035837 | biological_process | ergot alkaloid biosynthetic process |
| A | 0050364 | molecular_function | tryptophan dimethylallyltransferase activity |
| A | 1900809 | biological_process | fumigaclavine C biosynthetic process |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0009820 | biological_process | alkaloid metabolic process |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0035835 | biological_process | indole alkaloid biosynthetic process |
| B | 0035837 | biological_process | ergot alkaloid biosynthetic process |
| B | 0050364 | molecular_function | tryptophan dimethylallyltransferase activity |
| B | 1900809 | biological_process | fumigaclavine C biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE DST A 460 |
| Chain | Residue |
| A | ARG100 |
| A | ARG404 |
| A | TYR409 |
| A | TYR413 |
| A | TRP461 |
| A | HOH588 |
| A | HOH621 |
| A | HOH627 |
| A | HOH635 |
| A | LYS187 |
| A | TYR189 |
| A | ARG257 |
| A | LYS259 |
| A | TYR261 |
| A | MET328 |
| A | GLN343 |
| A | TYR345 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE TRP A 461 |
| Chain | Residue |
| A | ILE80 |
| A | LEU81 |
| A | GLU89 |
| A | THR102 |
| A | LYS174 |
| A | TYR189 |
| A | TYR191 |
| A | ARG244 |
| A | MET328 |
| A | TYR398 |
| A | DST460 |
| A | HOH540 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 462 |
| Chain | Residue |
| A | VAL319 |
| A | ILE320 |
| A | ASP322 |
| A | GLU323 |
| A | HOH728 |
| B | TYR314 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 463 |
| Chain | Residue |
| A | THR119 |
| A | HIS120 |
| A | TRP123 |
| A | LYS145 |
| A | THR149 |
| A | LEU150 |
| A | ASP405 |
| A | HOH504 |
| A | HOH572 |
| A | HOH752 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE DST B 460 |
| Chain | Residue |
| B | ARG100 |
| B | LYS187 |
| B | TYR189 |
| B | ARG257 |
| B | LYS259 |
| B | TYR261 |
| B | MET328 |
| B | GLN343 |
| B | TYR345 |
| B | ARG404 |
| B | TYR409 |
| B | TYR413 |
| B | TRP461 |
| B | HOH575 |
| B | HOH680 |
| B | HOH683 |
| B | HOH720 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE TRP B 461 |
| Chain | Residue |
| B | ILE80 |
| B | LEU81 |
| B | GLU89 |
| B | THR102 |
| B | LYS174 |
| B | TYR189 |
| B | TYR191 |
| B | ARG244 |
| B | TYR398 |
| B | DST460 |
| B | HOH467 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19706516 |
| Chain | Residue | Details |
| A | ILE80 | |
| A | TYR261 | |
| A | GLN343 | |
| A | TYR345 | |
| A | TYR409 | |
| A | TYR413 | |
| B | ILE80 | |
| B | GLU89 | |
| B | ARG100 | |
| B | LYS187 | |
| B | TYR189 | |
| A | GLU89 | |
| B | TYR191 | |
| B | ARG244 | |
| B | ARG257 | |
| B | LYS259 | |
| B | TYR261 | |
| B | GLN343 | |
| B | TYR345 | |
| B | TYR409 | |
| B | TYR413 | |
| A | ARG100 | |
| A | LYS187 | |
| A | TYR189 | |
| A | TYR191 | |
| A | ARG244 | |
| A | ARG257 | |
| A | LYS259 |
