3I3E
E. COLI (lacZ) BETA-GALACTOSIDASE (M542A)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
A | 0004565 | molecular_function | beta-galactosidase activity |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0005990 | biological_process | lactose catabolic process |
A | 0009341 | cellular_component | beta-galactosidase complex |
A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
A | 0030246 | molecular_function | carbohydrate binding |
A | 0031420 | molecular_function | alkali metal ion binding |
A | 0042802 | molecular_function | identical protein binding |
A | 0046872 | molecular_function | metal ion binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
B | 0004565 | molecular_function | beta-galactosidase activity |
B | 0005975 | biological_process | carbohydrate metabolic process |
B | 0005990 | biological_process | lactose catabolic process |
B | 0009341 | cellular_component | beta-galactosidase complex |
B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
B | 0030246 | molecular_function | carbohydrate binding |
B | 0031420 | molecular_function | alkali metal ion binding |
B | 0042802 | molecular_function | identical protein binding |
B | 0046872 | molecular_function | metal ion binding |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0003824 | molecular_function | catalytic activity |
C | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
C | 0004565 | molecular_function | beta-galactosidase activity |
C | 0005975 | biological_process | carbohydrate metabolic process |
C | 0005990 | biological_process | lactose catabolic process |
C | 0009341 | cellular_component | beta-galactosidase complex |
C | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
C | 0030246 | molecular_function | carbohydrate binding |
C | 0031420 | molecular_function | alkali metal ion binding |
C | 0042802 | molecular_function | identical protein binding |
C | 0046872 | molecular_function | metal ion binding |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0003824 | molecular_function | catalytic activity |
D | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
D | 0004565 | molecular_function | beta-galactosidase activity |
D | 0005975 | biological_process | carbohydrate metabolic process |
D | 0005990 | biological_process | lactose catabolic process |
D | 0009341 | cellular_component | beta-galactosidase complex |
D | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
D | 0030246 | molecular_function | carbohydrate binding |
D | 0031420 | molecular_function | alkali metal ion binding |
D | 0042802 | molecular_function | identical protein binding |
D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 3001 |
Chain | Residue |
A | GLU416 |
A | HIS418 |
A | GLU461 |
A | HOH4014 |
A | HOH4078 |
A | HOH4156 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 3002 |
Chain | Residue |
A | GLN163 |
A | ASP193 |
A | ASP15 |
A | ASN18 |
A | VAL21 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 3003 |
Chain | Residue |
A | GLN718 |
A | HOH4268 |
A | HOH4384 |
A | HOH4450 |
A | HOH4649 |
A | HOH4721 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG A 3009 |
Chain | Residue |
A | HOH4674 |
A | HOH5173 |
A | HOH5175 |
A | HOH7017 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NA A 3101 |
Chain | Residue |
A | ASP201 |
A | PHE601 |
A | ASN604 |
A | HOH4170 |
A | HOH4278 |
A | HOH7338 |
A | HOH7434 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A 3102 |
Chain | Residue |
A | PHE556 |
A | TYR559 |
A | PRO560 |
A | LEU562 |
A | HOH4410 |
A | HOH4652 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NA A 3103 |
Chain | Residue |
A | PHE931 |
A | PRO932 |
A | LEU967 |
A | THR970 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA A 3104 |
Chain | Residue |
A | SER647 |
A | GLU650 |
A | LEU670 |
A | HOH6122 |
A | DMS8425 |
site_id | AC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DMS A 8401 |
Chain | Residue |
A | THR229 |
A | VAL330 |
A | GLY331 |
A | ASN449 |
A | PRO451 |
A | ARG482 |
A | HOH4011 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS A 8402 |
Chain | Residue |
A | ARG557 |
A | HIS622 |
A | GLN628 |
A | HOH4205 |
site_id | BC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DMS A 8403 |
Chain | Residue |
A | LYS380 |
A | ASN383 |
A | PHE626 |
A | TYR642 |
A | TRP708 |
A | HOH4214 |
A | HOH7340 |
site_id | BC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE DMS A 8404 |
Chain | Residue |
A | PRO32 |
A | PHE33 |
A | ALA34 |
A | TRP36 |
A | ALA327 |
A | HOH4423 |
A | HOH4663 |
A | HOH7341 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS A 8405 |
Chain | Residue |
A | THR271 |
A | LEU291 |
A | ARG292 |
A | HOH7342 |
site_id | BC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS A 8406 |
Chain | Residue |
A | HIS316 |
A | GLY320 |
A | LEU322 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS A 8407 |
Chain | Residue |
A | ARG505 |
A | GLU508 |
A | PRO1001 |
A | VAL1003 |
A | HOH4037 |
site_id | BC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS A 8408 |
Chain | Residue |
A | LEU54 |
A | ASN55 |
A | HOH4764 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS A 8409 |
Chain | Residue |
A | VAL335 |
A | PRO480 |
A | HOH4212 |
A | HOH7346 |
site_id | BC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS A 8410 |
Chain | Residue |
A | PRO106 |
A | TRP191 |
A | HOH4371 |
site_id | CC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS A 8411 |
Chain | Residue |
A | PRO584 |
A | TRP585 |
A | SER586 |
A | ARG973 |
A | HOH4102 |
site_id | CC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS A 8412 |
Chain | Residue |
A | ARG292 |
A | HOH4615 |
A | GLU277 |
A | VAL289 |
A | THR290 |
site_id | CC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS A 8413 |
Chain | Residue |
A | GLY593 |
A | THR595 |
A | HOH7349 |
site_id | CC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS A 8414 |
Chain | Residue |
A | VAL84 |
A | VAL85 |
A | HIS93 |
site_id | CC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS A 8419 |
Chain | Residue |
A | TYR105 |
A | PRO106 |
A | THR108 |
A | HOH4481 |
site_id | CC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS A 8420 |
Chain | Residue |
A | ASP428 |
A | PRO430 |
D | ARG448 |
site_id | CC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS A 8421 |
Chain | Residue |
A | GLY94 |
A | TYR95 |
site_id | CC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS A 8425 |
Chain | Residue |
A | ASP648 |
A | ASN649 |
A | GLU650 |
A | ASN704 |
A | NA3104 |
C | LYS1023 |
site_id | CC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS A 8427 |
Chain | Residue |
A | TRP695 |
A | GLN719 |
A | ARG721 |
A | HOH4450 |
site_id | DC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS A 8501 |
Chain | Residue |
A | TRP36 |
A | ASP45 |
A | PRO47 |
A | HOH4757 |
site_id | DC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS A 8502 |
Chain | Residue |
A | GLU57 |
A | ARG59 |
A | LEU125 |
A | THR126 |
site_id | DC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS A 8503 |
Chain | Residue |
A | PHE629 |
A | ARG630 |
A | GLN718 |
A | TRP720 |
A | HOH4238 |
A | HOH5003 |
site_id | DC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS A 8504 |
Chain | Residue |
A | ARG37 |
A | SER132 |
A | TRP133 |
A | HIS216 |
site_id | DC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS A 8602 |
Chain | Residue |
A | GLN266 |
A | VAL267 |
site_id | DC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS A 8603 |
Chain | Residue |
A | ARG699 |
A | ILE714 |
A | TRP717 |
site_id | DC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS A 8604 |
Chain | Residue |
A | GLY283 |
A | GLY284 |
D | VAL421 |
site_id | DC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS A 8605 |
Chain | Residue |
A | ARG251 |
A | ASP252 |
D | ARG251 |
site_id | DC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS A 8608 |
Chain | Residue |
A | TYR472 |
A | THR494 |
A | THR496 |
A | ARG531 |
site_id | EC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS A 8609 |
Chain | Residue |
A | ARG630 |
A | SER632 |
A | THR635 |
A | GLU637 |
site_id | EC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS A 8610 |
Chain | Residue |
A | ARG230 |
A | PHE231 |
A | ASN232 |
A | VAL239 |
site_id | EC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS A 8612 |
Chain | Residue |
B | GLU40 |
B | TRP261 |
B | GLU264 |
site_id | EC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 3005 |
Chain | Residue |
A | HOH7322 |
A | HOH7323 |
D | HOH4674 |
D | HOH5173 |
D | HOH5175 |
site_id | EC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B 3001 |
Chain | Residue |
B | GLU416 |
B | HIS418 |
B | GLU461 |
B | HOH4014 |
B | HOH4078 |
B | HOH4156 |
site_id | EC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG B 3002 |
Chain | Residue |
B | ASP15 |
B | ASN18 |
B | VAL21 |
B | GLN163 |
B | ASP193 |
site_id | EC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B 3003 |
Chain | Residue |
B | GLN718 |
B | HOH4268 |
B | HOH4384 |
B | HOH4450 |
B | HOH4649 |
B | HOH4721 |
site_id | EC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NA B 3101 |
Chain | Residue |
B | ASP201 |
B | PHE601 |
B | ASN604 |
B | HOH4170 |
B | HOH4278 |
B | HOH7211 |
B | HOH7216 |
site_id | EC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA B 3102 |
Chain | Residue |
B | PHE556 |
B | TYR559 |
B | PRO560 |
B | LEU562 |
B | HOH4410 |
B | HOH4652 |
site_id | FC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NA B 3103 |
Chain | Residue |
B | PRO932 |
B | LEU967 |
B | THR970 |
B | HOH4558 |
site_id | FC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NA B 3104 |
Chain | Residue |
B | SER647 |
B | ASP648 |
B | ASN649 |
B | GLU650 |
B | LEU670 |
B | HOH7217 |
B | DMS8425 |
site_id | FC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS B 8401 |
Chain | Residue |
B | THR229 |
B | GLY331 |
B | ASN449 |
B | PRO451 |
B | ARG482 |
B | HOH4011 |
site_id | FC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS B 8402 |
Chain | Residue |
B | ARG557 |
B | HIS622 |
B | GLN625 |
B | GLN628 |
B | HOH4205 |
site_id | FC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS B 8403 |
Chain | Residue |
B | LYS380 |
B | ASN383 |
B | PHE626 |
B | TYR642 |
B | TRP708 |
B | HOH4214 |
site_id | FC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS B 8404 |
Chain | Residue |
B | PRO32 |
B | PHE33 |
B | ALA34 |
B | ASP45 |
B | ALA327 |
B | HOH4423 |
site_id | FC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS B 8405 |
Chain | Residue |
B | THR271 |
B | LEU291 |
B | ARG292 |
B | HOH4724 |
site_id | FC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS B 8406 |
Chain | Residue |
B | GLU314 |
B | HIS316 |
B | GLY320 |
site_id | FC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS B 8407 |
Chain | Residue |
B | GLU508 |
B | PRO1001 |
B | VAL1003 |
B | HOH4037 |
B | HOH7195 |
site_id | GC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS B 8408 |
Chain | Residue |
B | LEU54 |
B | ASN55 |
site_id | GC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS B 8409 |
Chain | Residue |
B | GLU334 |
B | PRO480 |
B | HOH4209 |
B | HOH4212 |
B | HOH7221 |
site_id | GC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS B 8410 |
Chain | Residue |
B | PRO106 |
B | ILE107 |
B | THR108 |
site_id | GC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS B 8411 |
Chain | Residue |
B | SER586 |
B | ARG973 |
B | HOH4102 |
site_id | GC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS B 8412 |
Chain | Residue |
B | GLY275 |
B | GLY276 |
B | THR290 |
B | ARG292 |
B | HOH6053 |
site_id | GC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS B 8413 |
Chain | Residue |
B | PRO106 |
B | PRO115 |
site_id | GC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS B 8414 |
Chain | Residue |
B | VAL84 |
B | VAL85 |
B | HIS93 |
site_id | GC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS B 8415 |
Chain | Residue |
B | LYS621 |
B | HOH4339 |
site_id | GC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS B 8416 |
Chain | Residue |
B | LEU250 |
B | ARG251 |
B | ASP252 |
site_id | HC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS B 8417 |
Chain | Residue |
B | PHE231 |
B | ASN232 |
B | GLU334 |
site_id | HC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS B 8421 |
Chain | Residue |
B | HIS93 |
B | GLY94 |
B | TYR95 |
site_id | HC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS B 8423 |
Chain | Residue |
B | TYR926 |
B | TYR962 |
B | ARG973 |
site_id | HC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS B 8425 |
Chain | Residue |
B | ASP648 |
B | ASN649 |
B | GLU650 |
B | ASN704 |
B | NA3104 |
site_id | HC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS B 8427 |
Chain | Residue |
B | GLN719 |
B | ARG721 |
B | HOH4284 |
B | HOH4552 |
site_id | HC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS B 8502 |
Chain | Residue |
B | GLU57 |
B | LEU125 |
B | THR126 |
B | HOH4539 |
site_id | HC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS B 8504 |
Chain | Residue |
B | ARG37 |
B | SER132 |
B | TRP133 |
B | HIS216 |
site_id | HC8 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DMS B 8508 |
Chain | Residue |
B | TYR962 |
site_id | HC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS B 8601 |
Chain | Residue |
B | VAL267 |
B | VAL295 |
B | GLU296 |
B | HOH4586 |
site_id | IC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS B 8602 |
Chain | Residue |
B | ASP45 |
B | ARG46 |
B | PRO47 |
site_id | IC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS B 8603 |
Chain | Residue |
B | ARG230 |
B | PHE231 |
B | ASN232 |
B | ARG237 |
B | ALA238 |
B | VAL239 |
site_id | IC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS B 8604 |
Chain | Residue |
B | TYR472 |
B | THR494 |
B | THR496 |
B | ASP497 |
B | HOH4681 |
B | HOH7290 |
site_id | IC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS B 8605 |
Chain | Residue |
B | SER269 |
B | ARG292 |
B | ASN294 |
site_id | IC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS B 8606 |
Chain | Residue |
B | TYR405 |
B | HOH4189 |
site_id | IC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS B 8607 |
Chain | Residue |
B | ALA707 |
B | SER709 |
site_id | IC7 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DMS B 8608 |
Chain | Residue |
B | GLY346 |
site_id | IC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS B 8609 |
Chain | Residue |
B | PHE608 |
B | ASP610 |
B | THR612 |
B | ARG973 |
site_id | IC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS B 8610 |
Chain | Residue |
B | ARG630 |
B | SER632 |
B | THR635 |
B | GLU637 |
B | LEU679 |
site_id | JC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS C 8420 |
Chain | Residue |
B | ASP428 |
C | VAL478 |
site_id | JC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 3001 |
Chain | Residue |
C | GLU416 |
C | HIS418 |
C | GLU461 |
C | HOH4014 |
C | HOH4078 |
C | HOH4156 |
site_id | JC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG C 3002 |
Chain | Residue |
C | ASP15 |
C | ASN18 |
C | VAL21 |
C | GLN163 |
C | ASP193 |
site_id | JC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 3003 |
Chain | Residue |
C | GLN718 |
C | HOH4268 |
C | HOH4384 |
C | HOH4450 |
C | HOH4649 |
C | HOH4721 |
site_id | JC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 3006 |
Chain | Residue |
A | HOH7052 |
B | HOH7156 |
C | HOH6089 |
C | HOH6218 |
C | HOH7207 |
C | HOH7267 |
site_id | JC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NA C 3101 |
Chain | Residue |
C | ASP201 |
C | PHE601 |
C | ASN604 |
C | HOH4170 |
C | HOH4278 |
C | HOH7262 |
C | HOH7268 |
site_id | JC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA C 3102 |
Chain | Residue |
C | PHE556 |
C | TYR559 |
C | PRO560 |
C | LEU562 |
C | HOH4410 |
C | HOH4652 |
site_id | JC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA C 3103 |
Chain | Residue |
C | PHE931 |
C | PRO932 |
C | LEU967 |
C | MET968 |
C | THR970 |
site_id | JC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA C 3104 |
Chain | Residue |
C | SER647 |
C | GLU650 |
C | LEU670 |
C | HOH5010 |
C | DMS8425 |
site_id | KC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS C 8401 |
Chain | Residue |
C | THR229 |
C | GLY331 |
C | ASN449 |
C | PRO451 |
C | ARG482 |
C | HOH4011 |
site_id | KC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS C 8402 |
Chain | Residue |
C | ARG557 |
C | HIS622 |
C | GLN628 |
C | HOH4205 |
site_id | KC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS C 8403 |
Chain | Residue |
C | LYS380 |
C | ASN383 |
C | PHE626 |
C | TYR642 |
C | TRP708 |
C | HOH4214 |
site_id | KC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE DMS C 8404 |
Chain | Residue |
C | PRO32 |
C | PHE33 |
C | TRP36 |
C | ASP45 |
C | ALA327 |
C | HOH4423 |
C | HOH4436 |
C | HOH4663 |
site_id | KC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS C 8405 |
Chain | Residue |
C | THR271 |
C | LEU291 |
C | ARG292 |
site_id | KC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DMS C 8407 |
Chain | Residue |
C | ARG505 |
C | GLU508 |
C | PRO1001 |
C | SER1002 |
C | VAL1003 |
C | HOH4037 |
C | HOH7279 |
site_id | KC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS C 8408 |
Chain | Residue |
C | LEU54 |
C | ASN55 |
C | HOH6186 |
site_id | KC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS C 8409 |
Chain | Residue |
C | VAL335 |
C | PRO480 |
C | HOH4209 |
C | HOH4212 |
site_id | KC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS C 8410 |
Chain | Residue |
C | PRO106 |
C | PRO115 |
C | TRP191 |
C | HOH4371 |
site_id | LC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS C 8411 |
Chain | Residue |
C | PRO584 |
C | SER586 |
C | ARG973 |
C | HOH4102 |
site_id | LC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS C 8412 |
Chain | Residue |
C | GLY275 |
C | GLU277 |
C | THR290 |
C | ARG292 |
C | HOH6053 |
site_id | LC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DMS C 8413 |
Chain | Residue |
C | THR595 |
site_id | LC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS C 8414 |
Chain | Residue |
C | VAL84 |
C | VAL85 |
C | HIS93 |
site_id | LC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS C 8415 |
Chain | Residue |
C | LYS621 |
C | TRP717 |
C | HOH4339 |
site_id | LC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS C 8416 |
Chain | Residue |
C | LEU250 |
C | ARG251 |
C | ASP252 |
site_id | LC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS C 8417 |
Chain | Residue |
C | PHE231 |
C | GLU334 |
site_id | LC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS C 8419 |
Chain | Residue |
C | TYR105 |
C | PRO106 |
C | HOH4481 |
site_id | LC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS C 1024 |
Chain | Residue |
C | ASP428 |
C | PRO430 |
site_id | MC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS C 8421 |
Chain | Residue |
C | HIS93 |
C | TYR95 |
C | HOH4650 |
site_id | MC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS C 8423 |
Chain | Residue |
C | TYR926 |
C | TYR962 |
C | ARG973 |
site_id | MC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS C 8425 |
Chain | Residue |
C | ASP648 |
C | ASN649 |
C | GLU650 |
C | ASN704 |
C | NA3104 |
site_id | MC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS C 8427 |
Chain | Residue |
C | GLN719 |
C | ARG721 |
C | HOH4284 |
C | HOH4450 |
C | HOH4552 |
site_id | MC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS C 8501 |
Chain | Residue |
C | ASP45 |
C | PRO47 |
site_id | MC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS C 8503 |
Chain | Residue |
C | PHE629 |
C | GLN718 |
C | TRP720 |
C | HOH4238 |
site_id | MC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS C 8504 |
Chain | Residue |
C | ARG37 |
C | SER132 |
C | TRP133 |
C | HIS216 |
site_id | MC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS C 8601 |
Chain | Residue |
C | VAL267 |
C | VAL295 |
C | GLU296 |
C | HOH4586 |
site_id | MC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS C 8602 |
Chain | Residue |
C | GLN266 |
C | VAL267 |
C | ALA268 |
D | LEU740 |
D | THR742 |
site_id | NC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS C 8603 |
Chain | Residue |
C | ALA707 |
C | SER709 |
C | GLU710 |
site_id | NC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS C 8604 |
Chain | Residue |
C | ALA268 |
C | SER269 |
C | ARG292 |
C | LEU293 |
C | ASN294 |
site_id | NC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS C 8605 |
Chain | Residue |
C | ILE305 |
C | ASN307 |
site_id | NC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS C 8606 |
Chain | Residue |
C | TYR472 |
C | THR494 |
C | THR496 |
C | ASP497 |
site_id | NC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS C 8607 |
Chain | Residue |
C | ARG230 |
C | PHE231 |
C | ASN232 |
C | ARG237 |
C | ALA238 |
C | VAL239 |
site_id | NC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG D 3001 |
Chain | Residue |
D | GLU416 |
D | HIS418 |
D | GLU461 |
D | HOH4014 |
D | HOH4078 |
D | HOH4156 |
site_id | NC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG D 3002 |
Chain | Residue |
D | ASP15 |
D | ASN18 |
D | VAL21 |
D | GLN163 |
D | ASP193 |
site_id | NC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG D 3003 |
Chain | Residue |
D | GLN718 |
D | HOH4268 |
D | HOH4384 |
D | HOH4450 |
D | HOH4649 |
D | HOH4721 |
site_id | NC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NA D 3101 |
Chain | Residue |
D | ASP201 |
D | PHE601 |
D | ASN604 |
D | HOH4278 |
D | HOH7319 |
D | HOH7341 |
D | HOH7378 |
site_id | OC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA D 3102 |
Chain | Residue |
D | PHE556 |
D | TYR559 |
D | PRO560 |
D | LEU562 |
D | HOH4410 |
D | HOH4652 |
site_id | OC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA D 3103 |
Chain | Residue |
D | PHE931 |
D | PRO932 |
D | LEU967 |
D | THR970 |
D | HOH4558 |
site_id | OC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA D 3104 |
Chain | Residue |
D | SER647 |
D | ASP648 |
D | ASN649 |
D | GLU650 |
D | LEU670 |
D | DMS8425 |
site_id | OC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS D 8401 |
Chain | Residue |
D | THR229 |
D | VAL330 |
D | GLY331 |
D | ASN449 |
D | PRO451 |
D | HOH4011 |
site_id | OC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS D 8402 |
Chain | Residue |
D | ARG557 |
D | HIS622 |
D | GLN628 |
D | HOH4205 |
site_id | OC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DMS D 8403 |
Chain | Residue |
D | LYS380 |
D | ASN383 |
D | PHE626 |
D | TYR642 |
D | TRP708 |
D | HOH4214 |
D | HOH4301 |
site_id | OC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS D 8404 |
Chain | Residue |
D | PRO32 |
D | PHE33 |
D | TRP36 |
D | ALA327 |
D | HOH7372 |
site_id | OC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS D 8405 |
Chain | Residue |
D | THR271 |
D | LEU291 |
D | ARG292 |
site_id | OC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS D 8406 |
Chain | Residue |
A | GLU136 |
D | GLU314 |
D | HIS316 |
D | GLY320 |
D | HOH7245 |
site_id | PC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS D 8407 |
Chain | Residue |
D | ARG505 |
D | GLU508 |
D | PRO1001 |
D | VAL1003 |
D | HOH4387 |
site_id | PC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS D 8408 |
Chain | Residue |
D | LEU54 |
D | ASN55 |
D | GLU57 |
D | HOH4764 |
site_id | PC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS D 8409 |
Chain | Residue |
D | VAL335 |
D | PRO480 |
D | HOH4212 |
site_id | PC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS D 8410 |
Chain | Residue |
D | PRO106 |
D | PRO115 |
D | HOH4371 |
site_id | PC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS D 8411 |
Chain | Residue |
D | PRO584 |
D | SER586 |
D | ARG973 |
D | HOH4102 |
site_id | PC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS D 8412 |
Chain | Residue |
D | GLY275 |
D | GLY276 |
D | THR290 |
D | ARG292 |
D | HOH4615 |
site_id | PC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS D 8413 |
Chain | Residue |
D | GLY593 |
D | THR595 |
site_id | PC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS D 8414 |
Chain | Residue |
D | THR83 |
D | VAL84 |
D | VAL85 |
D | HIS93 |
site_id | PC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS D 8415 |
Chain | Residue |
D | LYS621 |
D | TRP717 |
D | HOH4339 |
site_id | QC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS D 8416 |
Chain | Residue |
D | LEU250 |
D | ARG251 |
D | ASP252 |
site_id | QC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS D 8419 |
Chain | Residue |
D | TYR105 |
D | PRO106 |
D | ILE107 |
D | THR108 |
site_id | QC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DMS D 8421 |
Chain | Residue |
D | GLY94 |
site_id | QC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS D 8423 |
Chain | Residue |
D | TYR926 |
D | TYR962 |
D | ARG973 |
site_id | QC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS D 8425 |
Chain | Residue |
B | GLN1022 |
D | ASP648 |
D | ASN649 |
D | GLU650 |
D | ASN704 |
D | NA3104 |
site_id | QC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS D 8427 |
Chain | Residue |
D | TRP695 |
D | GLN719 |
D | ARG721 |
site_id | QC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS D 8501 |
Chain | Residue |
D | TRP36 |
D | ASP45 |
D | PRO47 |
D | HOH4512 |
site_id | QC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS D 8503 |
Chain | Residue |
D | PHE629 |
D | ARG630 |
D | GLN718 |
D | TRP720 |
D | HOH4238 |
site_id | QC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS D 8508 |
Chain | Residue |
D | SER923 |
D | TYR926 |
D | ARG961 |
D | TYR962 |
D | HOH4111 |
site_id | RC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS D 8701 |
Chain | Residue |
A | PRO218 |
A | ILE323 |
A | HOH5081 |
A | HOH5084 |
D | GLY320 |
site_id | RC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS D 8703 |
Chain | Residue |
D | GLN49 |
D | ASP130 |
site_id | RC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DMS D 8705 |
Chain | Residue |
D | ASP428 |
site_id | RC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS D 8706 |
Chain | Residue |
C | ARG721 |
C | LEU722 |
C | ALA723 |
D | ASP875 |
site_id | RC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS D 8707 |
Chain | Residue |
D | THR706 |
D | SER709 |
D | GLU710 |
site_id | RC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS D 8708 |
Chain | Residue |
D | ARG630 |
D | SER632 |
D | THR635 |
D | GLU637 |
site_id | RC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS D 8709 |
Chain | Residue |
D | ILE737 |
D | HIS739 |
D | GLY752 |
site_id | RC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS D 8711 |
Chain | Residue |
D | TRP133 |
D | LEU134 |
D | GLU136 |
D | GLY137 |
D | SER174 |
site_id | RC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS D 8712 |
Chain | Residue |
D | PHE231 |
D | ASN232 |
D | ASP233 |
D | PHE235 |
D | GLU334 |
Functional Information from PROSITE/UniProt
site_id | PS00608 |
Number of Residues | 15 |
Details | GLYCOSYL_HYDROL_F2_2 Glycosyl hydrolases family 2 acid/base catalyst. DRNHPSVIIWSlg.NE |
Chain | Residue | Details |
A | ASP447-GLU461 |
site_id | PS00719 |
Number of Residues | 26 |
Details | GLYCOSYL_HYDROL_F2_1 Glycosyl hydrolases family 2 signature 1. NaVRCSHYPnhplWYtlcDryGLYVV |
Chain | Residue | Details |
A | ASN385-VAL410 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:6420154 |
Chain | Residue | Details |
A | GLU461 | |
B | GLU461 | |
C | GLU461 | |
D | GLU461 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:1350782 |
Chain | Residue | Details |
A | GLU537 | |
B | GLU537 | |
C | GLU537 | |
D | GLU537 |
site_id | SWS_FT_FI3 |
Number of Residues | 28 |
Details | BINDING: |
Chain | Residue | Details |
B | ASP201 | |
B | GLU461 | |
B | GLU537 | |
B | PHE601 | |
B | ASN604 | |
B | TRP999 | |
C | ASN102 | |
C | ASP201 | |
C | GLU461 | |
C | GLU537 | |
C | PHE601 | |
C | ASN604 | |
C | TRP999 | |
D | ASN102 | |
D | ASP201 | |
D | GLU461 | |
D | GLU537 | |
D | PHE601 | |
D | ASN604 | |
D | TRP999 | |
A | ASP201 | |
A | GLU461 | |
A | GLU537 | |
A | PHE601 | |
A | ASN604 | |
A | TRP999 | |
B | ASN102 | |
A | ASN102 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11045615 |
Chain | Residue | Details |
A | ASN597 | |
B | ASN597 | |
C | ASN597 | |
D | ASN597 | |
A | GLU416 | |
A | HIS418 | |
B | GLU416 | |
B | HIS418 | |
C | GLU416 | |
C | HIS418 | |
D | GLU416 | |
D | HIS418 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | SITE: Transition state stabilizer |
Chain | Residue | Details |
C | HIS357 | |
C | HIS391 | |
D | HIS357 | |
D | HIS391 | |
A | HIS357 | |
A | HIS391 | |
B | HIS357 | |
B | HIS391 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | SITE: Important for ensuring that an appropriate proportion of lactose is converted to allolactose |
Chain | Residue | Details |
A | TRP999 | |
B | TRP999 | |
C | TRP999 | |
D | TRP999 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 10 |
Details | M-CSA 422 |
Chain | Residue | Details |
A | ASP201 | |
A | HIS357 | |
A | HIS391 | |
A | GLU416 | |
A | HIS418 | |
A | GLU461 | |
A | GLU537 | |
A | ASN597 | |
A | PHE601 | |
A | ASN604 |
site_id | MCSA2 |
Number of Residues | 10 |
Details | M-CSA 422 |
Chain | Residue | Details |
B | ASP201 | |
B | HIS357 | |
B | HIS391 | |
B | GLU416 | |
B | HIS418 | |
B | GLU461 | |
B | GLU537 | |
B | ASN597 | |
B | PHE601 | |
B | ASN604 |
site_id | MCSA3 |
Number of Residues | 10 |
Details | M-CSA 422 |
Chain | Residue | Details |
C | ASP201 | |
C | HIS357 | |
C | HIS391 | |
C | GLU416 | |
C | HIS418 | |
C | GLU461 | |
C | GLU537 | |
C | ASN597 | |
C | PHE601 | |
C | ASN604 |
site_id | MCSA4 |
Number of Residues | 10 |
Details | M-CSA 422 |
Chain | Residue | Details |
D | ASP201 | |
D | HIS357 | |
D | HIS391 | |
D | GLU416 | |
D | HIS418 | |
D | GLU461 | |
D | GLU537 | |
D | ASN597 | |
D | PHE601 | |
D | ASN604 |