Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0050784 | biological_process | cocaine catabolic process |
| A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 588 |
| Chain | Residue |
| A | LYS298 |
| A | ARG472 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 589 |
| Chain | Residue |
| A | ARG75 |
| A | GLY82 |
| A | GLU83 |
| A | HOH772 |
| A | HOH942 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 590 |
| Chain | Residue |
| A | ARG574 |
| A | HOH626 |
| A | HOH915 |
| A | PRO354 |
| A | ASP355 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 591 |
| Chain | Residue |
| A | TRP345 |
| A | HOH1381 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DBC A 592 |
| Chain | Residue |
| A | TYR44 |
| A | SER117 |
| A | TYR118 |
| A | TRP166 |
| A | HIS287 |
| A | LEU407 |
| A | GOL601 |
| A | HOH982 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 593 |
| Chain | Residue |
| A | LEU196 |
| A | ASN197 |
| A | VAL199 |
| A | ARG293 |
| A | PHE408 |
| A | HIS409 |
| A | ASN410 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 594 |
| Chain | Residue |
| A | ASP394 |
| A | ALA396 |
| A | LEU547 |
| A | MET550 |
| A | HOH716 |
| A | HOH768 |
| A | HOH769 |
| A | HOH1182 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 595 |
| Chain | Residue |
| A | GLU309 |
| A | ALA310 |
| A | ARG336 |
| A | TRP345 |
| A | HOH937 |
| A | HOH1116 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 596 |
| Chain | Residue |
| A | GLY364 |
| A | GLY365 |
| A | SER383 |
| A | GLY384 |
| A | THR385 |
| A | HOH823 |
| A | HOH999 |
| A | HOH1138 |
| A | HOH1348 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 597 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 598 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 599 |
| Chain | Residue |
| A | HIS563 |
| A | HOH1361 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 600 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 601 |
| Chain | Residue |
| A | TYR44 |
| A | SER117 |
| A | LYS169 |
| A | DBC592 |
| A | HOH970 |
| A | HOH984 |
| A | HOH1181 |
| site_id | BC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 3287 |
| Chain | Residue |
| A | SER454 |
| A | ALA455 |
| A | PRO469 |
| A | ASP470 |
| A | CYS551 |
| A | THR552 |
| A | ALA553 |
| A | HOH645 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | SER117 | |
| Chain | Residue | Details |
| A | ASP259 | |
| A | HIS287 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | TYR44 | |
| A | TYR118 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Probably involved in activating the substrate carbonyl and the acyl enzyme for hydrolysis |
| Chain | Residue | Details |
| A | TYR44 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 465 |
| Chain | Residue | Details |
| A | TYR44 | transition state stabiliser |
| A | SER117 | covalent catalysis, proton shuttle (general acid/base) |
| A | TYR118 | electrostatic stabiliser |
| A | TRP166 | activator |
| A | ASP259 | activator, electrostatic stabiliser |
| A | HIS287 | proton shuttle (general acid/base) |
