3I1U
Carboxypeptidase A Inhibited by a Thiirane Mechanism-Based inactivator
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 401 |
Chain | Residue |
A | HIS69 |
A | GLU72 |
A | HIS196 |
A | BTW402 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE BTW A 402 |
Chain | Residue |
A | HIS196 |
A | ILE243 |
A | TYR248 |
A | ALA250 |
A | THR268 |
A | GLU270 |
A | GOL311 |
A | ZN401 |
A | HIS69 |
A | GLU72 |
A | ARG127 |
A | ASN144 |
A | ARG145 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 310 |
Chain | Residue |
A | VAL183 |
A | LYS184 |
A | GLY187 |
A | ASN188 |
A | PHE189 |
A | GLN261 |
A | HOH448 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 311 |
Chain | Residue |
A | ARG127 |
A | GLU163 |
A | THR164 |
A | TYR248 |
A | BTW402 |
A | HOH593 |
site_id | AC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL A 312 |
Chain | Residue |
A | GLU43 |
A | GOL314 |
site_id | AC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 313 |
Chain | Residue |
A | TRP126 |
A | LYS128 |
A | CYS138 |
A | VAL139 |
A | PRO160 |
A | CYS161 |
A | GLU163 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 314 |
Chain | Residue |
A | SER121 |
A | GLN122 |
A | GOL312 |
A | HOH482 |
A | HOH494 |
A | HOH610 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 315 |
Chain | Residue |
A | TYR12 |
A | TRP73 |
A | ARG124 |
A | LEU280 |
A | LEU281 |
A | PRO282 |
site_id | AC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 316 |
Chain | Residue |
A | ARG40 |
A | SER41 |
A | TYR42 |
A | GLY44 |
A | VAL174 |
A | HOH443 |
A | HOH449 |
A | HOH464 |
Functional Information from PROSITE/UniProt
site_id | PS00132 |
Number of Residues | 23 |
Details | CARBOXYPEPT_ZN_1 Zinc carboxypeptidases, zinc-binding region 1 signature. PaIwIdlGiHSrEwITQatgvwF |
Chain | Residue | Details |
A | PRO60-PHE82 |
site_id | PS00133 |
Number of Residues | 11 |
Details | CARBOXYPEPT_ZN_2 Zinc carboxypeptidases, zinc-binding region 2 signature. HSYSQLLlYPY |
Chain | Residue | Details |
A | HIS196-TYR206 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01379 |
Chain | Residue | Details |
A | GLU270 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01379, ECO:0000269|PubMed:12431056, ECO:0007744|PDB:1IY7 |
Chain | Residue | Details |
A | HIS69 | |
A | GLU72 | |
A | HIS196 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12431056, ECO:0007744|PDB:1IY7 |
Chain | Residue | Details |
A | ARG127 | |
A | ASN144 | |
A | SER197 | |
A | TYR248 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1cbx |
Chain | Residue | Details |
A | ARG127 | |
A | GLU270 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1cbx |
Chain | Residue | Details |
A | ARG71 | |
A | GLU270 | |
A | ARG127 |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 171 |
Chain | Residue | Details |
A | HIS69 | metal ligand |
A | GLU72 | metal ligand |
A | ARG127 | electrostatic stabiliser, hydrogen bond donor |
A | HIS196 | metal ligand |
A | GLU270 | covalently attached, electrofuge, electrophile, hydrogen bond acceptor, hydrogen bond donor, nucleophile, proton acceptor, proton donor |