3HWS

Crystal structure of nucleotide-bound hexameric ClpX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0006457	biological_process	protein folding
A	0016887	molecular_function	ATP hydrolysis activity
A	0051082	molecular_function	unfolded protein binding
A	0140662	molecular_function	ATP-dependent protein folding chaperone
B	0005524	molecular_function	ATP binding
B	0006457	biological_process	protein folding
B	0016887	molecular_function	ATP hydrolysis activity
B	0051082	molecular_function	unfolded protein binding
B	0140662	molecular_function	ATP-dependent protein folding chaperone
C	0005524	molecular_function	ATP binding
C	0006457	biological_process	protein folding
C	0016887	molecular_function	ATP hydrolysis activity
C	0051082	molecular_function	unfolded protein binding
C	0140662	molecular_function	ATP-dependent protein folding chaperone
D	0005524	molecular_function	ATP binding
D	0006457	biological_process	protein folding
D	0016887	molecular_function	ATP hydrolysis activity
D	0051082	molecular_function	unfolded protein binding
D	0140662	molecular_function	ATP-dependent protein folding chaperone
E	0005524	molecular_function	ATP binding
E	0006457	biological_process	protein folding
E	0016887	molecular_function	ATP hydrolysis activity
E	0051082	molecular_function	unfolded protein binding
E	0140662	molecular_function	ATP-dependent protein folding chaperone
F	0005524	molecular_function	ATP binding
F	0006457	biological_process	protein folding
F	0016887	molecular_function	ATP hydrolysis activity
F	0051082	molecular_function	unfolded protein binding
F	0140662	molecular_function	ATP-dependent protein folding chaperone

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP A 600

Chain	Residue
A	TYR77
A	LEU127
A	LEU317
A	ALA369
B	SO4709
A	VAL78
A	ILE79
A	PRO120
A	GLY122
A	SER123
A	GLY124
A	LYS125
A	THR126

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 700

Chain	Residue
A	ARG71
A	LYS86

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 701

Chain	Residue
A	PHE140
A	THR141
A	MET142
A	LYS168

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 705

Chain	Residue
A	GLY80
A	GLN81
A	GLU82
A	ASN315

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP B 601

Chain	Residue
B	TYR77
B	VAL78
B	ILE79
B	PRO120
B	THR121
B	GLY122
B	SER123
B	GLY124
B	LYS125
B	THR126
B	LEU127
B	ILE325
B	ALA369
B	ARG370
B	SO4708
B	MG901

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 702

Chain	Residue
B	GLN81
B	GLU82
B	GLN83
B	ASN315

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 707

Chain	Residue
B	GLY102
B	ASP103
B	THR104

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 708

Chain	Residue
B	ADP601
B	MG901

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 709

Chain	Residue
A	ADP600
B	HOH802

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG B 901

Chain	Residue
B	ADP601
B	SO4708

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 500

Chain	Residue
C	PRO120
C	THR121
C	GLY122
C	SER123
C	GLY124
C	LYS125
C	THR126

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 703

Chain	Residue
C	THR141
C	MET142
C	LYS168

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 704

Chain	Residue
C	LYS361
C	ARG365

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 706

Chain	Residue
C	GLN81
C	ASN315

---

site_id	BC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP D 602

Chain	Residue
D	TYR77
D	VAL78
D	ILE79
D	GLY122
D	SER123
D	GLY124
D	LYS125
D	THR126
D	LEU127
D	ILE325
D	ALA369
D	ARG370

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 710

Chain	Residue
B	LYS86
D	HIS68
D	ASN72

---

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG D 900

Chain	Residue
D	ASP294

---

site_id	BC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP E 603

Chain	Residue
E	TYR77
E	VAL78
E	ILE79
E	PRO120
E	GLY122
E	SER123
E	GLY124
E	LYS125
E	THR126
E	LEU127
E	ILE325
E	PRO329
E	ALA369
E	ARG370

---

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 F 500

Chain	Residue
F	SER123
F	GLY124
F	LYS125
F	THR126
F	PRO120
F	THR121
F	GLY122

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00175, ECO:0000269|PubMed:19914167, ECO:0000269|PubMed:23622246

Chain	Residue	Details
A	PRO120
B	PRO120
C	PRO120
D	PRO120
E	PRO120
F	PRO120

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