3HVX
Escherichia coli Thiol peroxidase (Tpx) resolving cysteine to serine mutant (C95S) with an intermolecular disulfide bond
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008379 | molecular_function | thioredoxin peroxidase activity |
| A | 0016209 | molecular_function | antioxidant activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008379 | molecular_function | thioredoxin peroxidase activity |
| B | 0016209 | molecular_function | antioxidant activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0008379 | molecular_function | thioredoxin peroxidase activity |
| C | 0016209 | molecular_function | antioxidant activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0034599 | biological_process | cellular response to oxidative stress |
| C | 0042597 | cellular_component | periplasmic space |
| C | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0008379 | molecular_function | thioredoxin peroxidase activity |
| D | 0016209 | molecular_function | antioxidant activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0034599 | biological_process | cellular response to oxidative stress |
| D | 0042597 | cellular_component | periplasmic space |
| D | 0098869 | biological_process | cellular oxidant detoxification |
| D | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 169 |
| Chain | Residue |
| A | THR27 |
| A | PHE28 |
| A | THR39 |
| A | LEU40 |
| A | GLY41 |
| A | HOH213 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 170 |
| Chain | Residue |
| A | GLN148 |
| A | ASP151 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 169 |
| Chain | Residue |
| B | LEU149 |
| B | ASP151 |
| B | GLN148 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 170 |
| Chain | Residue |
| B | THR27 |
| B | LEU40 |
| B | GLY41 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 171 |
| Chain | Residue |
| B | ARG133 |
| B | HOH336 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 1 |
| Chain | Residue |
| C | THR27 |
| C | LEU40 |
| C | GLY41 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 169 |
| Chain | Residue |
| C | ARG133 |
| C | GLU156 |
| C | HOH593 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 170 |
| Chain | Residue |
| C | GLN148 |
| C | ASP151 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL D 169 |
| Chain | Residue |
| D | THR27 |
| D | PHE28 |
| D | THR39 |
| D | LEU40 |
| D | GLY41 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL D 170 |
| Chain | Residue |
| D | GLN8 |
| D | GLU152 |
| D | ILE153 |
| D | THR154 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL D 171 |
| Chain | Residue |
| D | GLN148 |
| D | ASP151 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 596 |
| Details | Domain: {"description":"Thioredoxin","evidences":[{"source":"HAMAP-Rule","id":"MF_00269","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_00269","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12514184","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
