3HVX

Escherichia coli Thiol peroxidase (Tpx) resolving cysteine to serine mutant (C95S) with an intermolecular disulfide bond

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0032843	molecular_function	hydroperoxide reductase activity
A	0034599	biological_process	cellular response to oxidative stress
A	0042597	cellular_component	periplasmic space
A	0098869	biological_process	cellular oxidant detoxification
A	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
B	0004601	molecular_function	peroxidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0032843	molecular_function	hydroperoxide reductase activity
B	0034599	biological_process	cellular response to oxidative stress
B	0042597	cellular_component	periplasmic space
B	0098869	biological_process	cellular oxidant detoxification
B	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
C	0004601	molecular_function	peroxidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0032843	molecular_function	hydroperoxide reductase activity
C	0034599	biological_process	cellular response to oxidative stress
C	0042597	cellular_component	periplasmic space
C	0098869	biological_process	cellular oxidant detoxification
C	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
D	0004601	molecular_function	peroxidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008379	molecular_function	thioredoxin peroxidase activity
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0032843	molecular_function	hydroperoxide reductase activity
D	0034599	biological_process	cellular response to oxidative stress
D	0042597	cellular_component	periplasmic space
D	0098869	biological_process	cellular oxidant detoxification
D	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 169

Chain	Residue
A	THR27
A	PHE28
A	THR39
A	LEU40
A	GLY41
A	HOH213

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 170

Chain	Residue
A	GLN148
A	ASP151

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 169

Chain	Residue
B	LEU149
B	ASP151
B	GLN148

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 170

Chain	Residue
B	THR27
B	LEU40
B	GLY41

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site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 171

Chain	Residue
B	ARG133
B	HOH336

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site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 1

Chain	Residue
C	THR27
C	LEU40
C	GLY41

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site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 169

Chain	Residue
C	ARG133
C	GLU156
C	HOH593

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site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 170

Chain	Residue
C	GLN148
C	ASP151

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site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL D 169

Chain	Residue
D	THR27
D	PHE28
D	THR39
D	LEU40
D	GLY41

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 170

Chain	Residue
D	GLN8
D	GLU152
D	ILE153
D	THR154

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site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 171

Chain	Residue
D	GLN148
D	ASP151

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000255|HAMAP-Rule:MF_00269, ECO:0000269|PubMed:12514184

Chain	Residue	Details
A	CYS61
B	CYS61
C	CYS61
D	CYS61

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