Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3HVU

1.95 Angstrom Crystal Structure of Complex of Hypoxanthine-Guanine Phosphoribosyltransferase from Bacillus anthracis with 2-(N-morpholino)ethanesulfonic acid (MES)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0006177	biological_process	GMP biosynthetic process
A	0006178	biological_process	guanine salvage
A	0006188	biological_process	IMP biosynthetic process
A	0032263	biological_process	GMP salvage
A	0032264	biological_process	IMP salvage
A	0043101	biological_process	purine-containing compound salvage
A	0046100	biological_process	hypoxanthine metabolic process
A	0052657	molecular_function	guanine phosphoribosyltransferase activity
B	0000287	molecular_function	magnesium ion binding
B	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006166	biological_process	purine ribonucleoside salvage
B	0006177	biological_process	GMP biosynthetic process
B	0006178	biological_process	guanine salvage
B	0006188	biological_process	IMP biosynthetic process
B	0032263	biological_process	GMP salvage
B	0032264	biological_process	IMP salvage
B	0043101	biological_process	purine-containing compound salvage
B	0046100	biological_process	hypoxanthine metabolic process
B	0052657	molecular_function	guanine phosphoribosyltransferase activity
C	0000287	molecular_function	magnesium ion binding
C	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006166	biological_process	purine ribonucleoside salvage
C	0006177	biological_process	GMP biosynthetic process
C	0006178	biological_process	guanine salvage
C	0006188	biological_process	IMP biosynthetic process
C	0032263	biological_process	GMP salvage
C	0032264	biological_process	IMP salvage
C	0043101	biological_process	purine-containing compound salvage
C	0046100	biological_process	hypoxanthine metabolic process
C	0052657	molecular_function	guanine phosphoribosyltransferase activity
D	0000287	molecular_function	magnesium ion binding
D	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006166	biological_process	purine ribonucleoside salvage
D	0006177	biological_process	GMP biosynthetic process
D	0006178	biological_process	guanine salvage
D	0006188	biological_process	IMP biosynthetic process
D	0032263	biological_process	GMP salvage
D	0032264	biological_process	IMP salvage
D	0043101	biological_process	purine-containing compound salvage
D	0046100	biological_process	hypoxanthine metabolic process
D	0052657	molecular_function	guanine phosphoribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MES A 181

Chain	Residue
A	GLU99
A	LEU108
A	ASP100
A	ILE101
A	ILE102
A	ASP103
A	SER104
A	GLY105
A	LEU106
A	THR107

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 182

Chain	Residue
A	TYR31
A	THR34
A	THR58
A	TYR59

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MES B 181

Chain	Residue
B	GLU99
B	ASP100
B	ILE101
B	ASP103
B	SER104
B	GLY105
B	LEU106
B	THR107
B	LEU108

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA B 182

Chain	Residue
B	TYR31
B	THR34
B	THR58
B	TYR59

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MES C 181

Chain	Residue
C	GLU99
C	ASP100
C	ILE101
C	ILE102
C	ASP103
C	SER104
C	GLY105
C	LEU106
C	THR107
C	LEU108
C	HOH219

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA C 182

Chain	Residue
C	TYR31
C	THR34
C	THR58
C	TYR59

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MES D 181

Chain	Residue
D	GLU99
D	ASP100
D	ILE101
D	ILE102
D	ASP103
D	SER104
D	GLY105
D	LEU106
D	THR107
D	LEU108

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA D 182

Chain	Residue
D	TYR31
D	THR34
D	THR58
D	TYR59

Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. ILIVEDIIDSGlT

Chain	Residue	Details
A	ILE95-THR107

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
A	ASP103
A	ASP100
A	LYS131
A	GLU99

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
B	ASP103
B	ASP100
B	LYS131
B	GLU99

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
C	ASP103
C	ASP100
C	LYS131
C	GLU99

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
D	ASP103
D	ASP100
D	LYS131
D	GLU99

site_id	CSA5
Number of Residues	5
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
A	ASP103
A	ARG135
A	ASP100
A	LYS131
A	GLU99

site_id	CSA6
Number of Residues	5
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
B	ASP103
B	ARG135
B	ASP100
B	LYS131
B	GLU99

site_id	CSA7
Number of Residues	5
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
C	ASP103
C	ARG135
C	ASP100
C	LYS131
C	GLU99

site_id	CSA8
Number of Residues	5
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
D	ASP103
D	ARG135
D	ASP100
D	LYS131
D	GLU99

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)