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3HVS

Escherichia coli Thiol peroxidase (Tpx) wild type disulfide form

Functional Information from GO Data
ChainGOidnamespacecontents
A0004601molecular_functionperoxidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0008379molecular_functionthioredoxin peroxidase activity
A0016209molecular_functionantioxidant activity
A0016491molecular_functionoxidoreductase activity
A0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
A0032843molecular_functionhydroperoxide reductase activity
A0034599biological_processcellular response to oxidative stress
A0042597cellular_componentperiplasmic space
A0098869biological_processcellular oxidant detoxification
A0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
B0004601molecular_functionperoxidase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0008379molecular_functionthioredoxin peroxidase activity
B0016209molecular_functionantioxidant activity
B0016491molecular_functionoxidoreductase activity
B0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
B0032843molecular_functionhydroperoxide reductase activity
B0034599biological_processcellular response to oxidative stress
B0042597cellular_componentperiplasmic space
B0098869biological_processcellular oxidant detoxification
B0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE CIT A 1
ChainResidue
AALA62
ATYR159
AHOH217
AHOH255
AHOH281
AHOH351
AHOH406
AHOH590
ASER64
AVAL65
AARG133
AILE153
ATHR154
ATHR155
AGLU156
APRO157

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE CIT B 169
ChainResidue
BSER64
BVAL65
BARG133
BILE153
BTHR154
BTHR155
BGLU156
BPRO157
BTYR159
BHOH253
BHOH262
BHOH451
BHOH497

Functional Information from PROSITE/UniProt
site_idPS01265
Number of Residues12
DetailsTPX Tpx family signature. SaDLPFAqsRFC
ChainResidueDetails
ASER84-CYS95

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000255|HAMAP-Rule:MF_00269, ECO:0000269|PubMed:12514184
ChainResidueDetails
ACYS61
BCYS61

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PDB entries from 2024-07-17

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