3HVS

Escherichia coli Thiol peroxidase (Tpx) wild type disulfide form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
A	0032843	molecular_function	hydroperoxide reductase activity
A	0034599	biological_process	cellular response to oxidative stress
A	0042597	cellular_component	periplasmic space
A	0098869	biological_process	cellular oxidant detoxification
A	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
B	0004601	molecular_function	peroxidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
B	0032843	molecular_function	hydroperoxide reductase activity
B	0034599	biological_process	cellular response to oxidative stress
B	0042597	cellular_component	periplasmic space
B	0098869	biological_process	cellular oxidant detoxification
B	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE CIT A 1

Chain	Residue
A	ALA62
A	TYR159
A	HOH217
A	HOH255
A	HOH281
A	HOH351
A	HOH406
A	HOH590
A	SER64
A	VAL65
A	ARG133
A	ILE153
A	THR154
A	THR155
A	GLU156
A	PRO157

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site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CIT B 169

Chain	Residue
B	SER64
B	VAL65
B	ARG133
B	ILE153
B	THR154
B	THR155
B	GLU156
B	PRO157
B	TYR159
B	HOH253
B	HOH262
B	HOH451
B	HOH497

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Functional Information from PROSITE/UniProt

site_id	PS01265
Number of Residues	12
Details	TPX Tpx family signature. SaDLPFAqsRFC

Chain	Residue	Details
A	SER84-CYS95

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	298
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"HAMAP-Rule","id":"MF_00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_00269","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12514184","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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