3HVS
Escherichia coli Thiol peroxidase (Tpx) wild type disulfide form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008379 | molecular_function | thioredoxin peroxidase activity |
| A | 0016209 | molecular_function | antioxidant activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016684 | molecular_function | oxidoreductase activity, acting on peroxide as acceptor |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008379 | molecular_function | thioredoxin peroxidase activity |
| B | 0016209 | molecular_function | antioxidant activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016684 | molecular_function | oxidoreductase activity, acting on peroxide as acceptor |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE CIT A 1 |
| Chain | Residue |
| A | ALA62 |
| A | TYR159 |
| A | HOH217 |
| A | HOH255 |
| A | HOH281 |
| A | HOH351 |
| A | HOH406 |
| A | HOH590 |
| A | SER64 |
| A | VAL65 |
| A | ARG133 |
| A | ILE153 |
| A | THR154 |
| A | THR155 |
| A | GLU156 |
| A | PRO157 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CIT B 169 |
| Chain | Residue |
| B | SER64 |
| B | VAL65 |
| B | ARG133 |
| B | ILE153 |
| B | THR154 |
| B | THR155 |
| B | GLU156 |
| B | PRO157 |
| B | TYR159 |
| B | HOH253 |
| B | HOH262 |
| B | HOH451 |
| B | HOH497 |
Functional Information from PROSITE/UniProt
| site_id | PS01265 |
| Number of Residues | 12 |
| Details | TPX Tpx family signature. SaDLPFAqsRFC |
| Chain | Residue | Details |
| A | SER84-CYS95 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 298 |
| Details | Domain: {"description":"Thioredoxin","evidences":[{"source":"HAMAP-Rule","id":"MF_00269","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_00269","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12514184","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
