Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0006584 | biological_process | catecholamine metabolic process |
| A | 0008171 | molecular_function | O-methyltransferase activity |
| A | 0016206 | molecular_function | catechol O-methyltransferase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0006584 | biological_process | catecholamine metabolic process |
| B | 0008171 | molecular_function | O-methyltransferase activity |
| B | 0016206 | molecular_function | catechol O-methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE 705 A 1 |
| Chain | Residue |
| A | HOH40 |
| A | SER162 |
| A | GLN163 |
| A | ASP184 |
| A | HIS185 |
| A | TRP186 |
| A | LYS187 |
| A | ARG189 |
| A | ASP212 |
| A | ASN213 |
| A | GLU242 |
| A | MET83 |
| A | MG265 |
| A | HOH317 |
| A | HOH324 |
| A | HOH401 |
| B | 7052 |
| B | TRP81 |
| B | LEU241 |
| B | MET244 |
| A | GLY109 |
| A | TYR111 |
| A | GLU133 |
| A | MET134 |
| A | TYR138 |
| A | GLY160 |
| A | ALA161 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 265 |
| Chain | Residue |
| A | 7051 |
| A | ASP184 |
| A | ASP212 |
| A | ASN213 |
| A | HOH401 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 266 |
| Chain | Residue |
| A | ASP87 |
| A | ALA88 |
| A | TYR243 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE BTB A 267 |
| Chain | Residue |
| A | CYS76 |
| A | THR77 |
| A | LYS79 |
| A | TRP81 |
| A | HOH433 |
| B | 7052 |
| B | TRP186 |
| B | LYS187 |
| B | ASP188 |
| B | PRO217 |
| B | HOH373 |
| site_id | AC5 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE 705 B 2 |
| Chain | Residue |
| A | 7051 |
| A | TRP81 |
| A | LEU241 |
| A | MET244 |
| A | BTB267 |
| A | HOH425 |
| B | TRP81 |
| B | MET83 |
| B | GLY109 |
| B | TYR111 |
| B | GLU133 |
| B | MET134 |
| B | ASN135 |
| B | TYR138 |
| B | GLY160 |
| B | ALA161 |
| B | SER162 |
| B | GLN163 |
| B | ASP184 |
| B | HIS185 |
| B | TRP186 |
| B | LYS187 |
| B | ARG189 |
| B | ASP212 |
| B | ASN213 |
| B | PRO217 |
| B | GLU242 |
| B | MG265 |
| B | HOH345 |
| B | HOH433 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 265 |
| Chain | Residue |
| B | 7052 |
| B | ASP184 |
| B | ASP212 |
| B | ASN213 |
| B | HOH433 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01019","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12237326","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01019","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1vid |
| Chain | Residue | Details |
| A | LYS187 | |
| A | GLU242 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1vid |
| Chain | Residue | Details |
| B | LYS187 | |
| B | GLU242 | |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 915 |
| Chain | Residue | Details |
| A | ASP184 | metal ligand |
| A | LYS187 | proton shuttle (general acid/base) |
| A | ASP212 | metal ligand |
| A | ASN213 | metal ligand |
| A | GLU242 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 915 |
| Chain | Residue | Details |
| B | ASP184 | metal ligand |
| B | LYS187 | proton shuttle (general acid/base) |
| B | ASP212 | metal ligand |
| B | ASN213 | metal ligand |
| B | GLU242 | electrostatic stabiliser |
