Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0006584 | biological_process | catecholamine metabolic process |
A | 0008171 | molecular_function | O-methyltransferase activity |
A | 0016206 | molecular_function | catechol O-methyltransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 32 |
Details | BINDING SITE FOR RESIDUE 542 A 1 |
Chain | Residue |
A | CXS3 |
A | ALA140 |
A | GLN143 |
A | GLN144 |
A | GLY160 |
A | ALA161 |
A | SER162 |
A | GLN163 |
A | ASP184 |
A | HIS185 |
A | TRP186 |
A | HOH43 |
A | LYS187 |
A | ARG189 |
A | ASP212 |
A | ASN213 |
A | VAL216 |
A | PRO217 |
A | LEU241 |
A | GLU242 |
A | MG265 |
A | HOH332 |
A | MET83 |
A | HOH337 |
A | HOH369 |
A | HOH379 |
A | GLY109 |
A | TYR111 |
A | GLU133 |
A | MET134 |
A | ASN135 |
A | TYR138 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE CXS A 3 |
Chain | Residue |
A | 5421 |
A | HOH29 |
A | LYS48 |
A | TRP81 |
A | ALA139 |
A | ALA140 |
A | GLN143 |
A | ILE157 |
A | MET244 |
A | SO4270 |
A | HOH398 |
A | HOH401 |
A | HOH471 |
site_id | AC3 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE CXS A 2 |
Chain | Residue |
A | LEU195 |
A | GLU198 |
A | TYR225 |
A | SER231 |
A | PHE232 |
A | TYR240 |
A | LYS245 |
A | PRO258 |
A | HOH417 |
A | HOH429 |
A | HOH512 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 265 |
Chain | Residue |
A | 5421 |
A | ASP184 |
A | ASP212 |
A | ASN213 |
A | HOH369 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CL A 266 |
Chain | Residue |
A | SER101 |
A | SER103 |
A | HOH294 |
A | HOH344 |
A | HOH371 |
A | HOH454 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CL A 267 |
Chain | Residue |
A | VAL226 |
A | ARG227 |
A | SER229 |
A | PHE232 |
A | HOH291 |
A | HOH509 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL A 268 |
Chain | Residue |
A | ASP87 |
A | ALA88 |
A | TYR243 |
A | HOH361 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 269 |
Chain | Residue |
A | PRO125 |
A | GLY126 |
A | ARG128 |
A | LYS154 |
site_id | AC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 A 270 |
Chain | Residue |
A | CXS3 |
A | TRP81 |
A | LEU158 |
A | ASN159 |
A | MET244 |
A | HOH313 |
A | HOH384 |
A | HOH511 |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ASP184 | |
A | VAL85 | |
A | SER115 | |
A | GLU133 | |
Chain | Residue | Details |
A | MET134 | |
A | SER162 | |
A | GLU107 | |
site_id | SWS_FT_FI3 |
Number of Residues | 5 |
Details | BINDING: |
Chain | Residue | Details |
A | LYS187 | |
A | ASP212 | |
A | ASN213 | |
A | GLU242 | |
A | GLY160 | |
Chain | Residue | Details |
A | SER259 | |
A | SER260 | |
A | SER264 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 915 |
Chain | Residue | Details |
A | ASP184 | metal ligand |
A | LYS187 | proton shuttle (general acid/base) |
A | ASP212 | metal ligand |
A | ASN213 | metal ligand |
A | GLU242 | electrostatic stabiliser |