Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004517 | molecular_function | nitric-oxide synthase activity |
| A | 0006809 | biological_process | nitric oxide biosynthetic process |
| B | 0004517 | molecular_function | nitric-oxide synthase activity |
| B | 0006809 | biological_process | nitric oxide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE HEM A 750 |
| Chain | Residue |
| A | TRP409 |
| A | GLU592 |
| A | TRP678 |
| A | PHE704 |
| A | TYR706 |
| A | CMO751 |
| A | H4B760 |
| A | HAR770 |
| A | ACT860 |
| A | HOH907 |
| A | HOH909 |
| A | ARG414 |
| A | HOH926 |
| A | HOH942 |
| A | HOH997 |
| A | CYS415 |
| A | VAL416 |
| A | SER457 |
| A | PHE584 |
| A | SER585 |
| A | GLY586 |
| A | TRP587 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CMO A 751 |
| Chain | Residue |
| A | PHE584 |
| A | HEM750 |
| A | HAR770 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE H4B A 760 |
| Chain | Residue |
| A | SER334 |
| A | ARG596 |
| A | VAL677 |
| A | TRP678 |
| A | HEM750 |
| A | HOH901 |
| A | HOH909 |
| A | HOH924 |
| A | HOH946 |
| A | HOH1025 |
| B | TRP676 |
| B | PHE691 |
| B | HIS692 |
| B | GLU694 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE HAR A 770 |
| Chain | Residue |
| A | GLN478 |
| A | TYR562 |
| A | PRO565 |
| A | VAL567 |
| A | GLY586 |
| A | TRP587 |
| A | TYR588 |
| A | GLU592 |
| A | ASP597 |
| A | HEM750 |
| A | CMO751 |
| A | HOH904 |
| A | HOH908 |
| A | HOH1134 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 860 |
| Chain | Residue |
| A | GLY417 |
| A | TRP587 |
| A | SER657 |
| A | HEM750 |
| A | HOH1062 |
| A | HOH1121 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 900 |
| Chain | Residue |
| A | CYS326 |
| A | CYS331 |
| B | CYS326 |
| B | CYS331 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 880 |
| Chain | Residue |
| A | LYS319 |
| A | GLN364 |
| A | ARG669 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 882 |
| Chain | Residue |
| A | ILE402 |
| A | LYS406 |
| A | LEU424 |
| A | GLN425 |
| A | VAL426 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 885 |
| Chain | Residue |
| A | THR492 |
| A | LEU493 |
| A | GLY494 |
| A | ARG516 |
| A | TYR604 |
| A | GOL886 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 886 |
| Chain | Residue |
| A | ASN605 |
| A | GLU609 |
| A | GOL885 |
| A | HOH996 |
| site_id | BC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE HEM B 750 |
| Chain | Residue |
| B | H4B1760 |
| B | HAR1770 |
| B | TRP409 |
| B | ARG414 |
| B | CYS415 |
| B | PHE584 |
| B | SER585 |
| B | GLY586 |
| B | TRP587 |
| B | GLU592 |
| B | TRP678 |
| B | PHE704 |
| B | TYR706 |
| B | CMO751 |
| B | HOH902 |
| B | HOH906 |
| B | HOH934 |
| B | HOH938 |
| B | HOH1018 |
| B | HOH1030 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CMO B 751 |
| Chain | Residue |
| B | PHE584 |
| B | HEM750 |
| B | HAR1770 |
| site_id | BC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE H4B B 1760 |
| Chain | Residue |
| A | TRP676 |
| A | PHE691 |
| A | HIS692 |
| B | SER334 |
| B | MET336 |
| B | ARG596 |
| B | VAL677 |
| B | TRP678 |
| B | HEM750 |
| B | HOH906 |
| B | HOH909 |
| B | HOH940 |
| B | HOH957 |
| B | HOH1145 |
| site_id | BC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE HAR B 1770 |
| Chain | Residue |
| B | GLN478 |
| B | TYR562 |
| B | PRO565 |
| B | VAL567 |
| B | GLY586 |
| B | TRP587 |
| B | TYR588 |
| B | GLU592 |
| B | ASP597 |
| B | HEM750 |
| B | CMO751 |
| B | HOH907 |
| B | HOH945 |
| B | HOH976 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT B 1860 |
| Chain | Residue |
| B | GLY417 |
| B | GLN420 |
| B | TRP587 |
| B | SER657 |
| B | HOH1039 |
| B | HOH1195 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 881 |
| Chain | Residue |
| B | GLN364 |
| B | ARG669 |
| B | THR701 |
| B | HOH989 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 883 |
| Chain | Residue |
| B | SER477 |
| B | ALA497 |
| B | ASN498 |
| B | ASN569 |
| B | ASP709 |
| B | HOH904 |
| B | HOH1041 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 884 |
| Chain | Residue |
| B | TYR604 |
| B | ASN605 |
| B | ILE606 |
| B | GLU609 |
| B | HOH1090 |
Functional Information from PROSITE/UniProt
| site_id | PS60001 |
| Number of Residues | 8 |
| Details | NOS Nitric oxide synthase (NOS) signature. RCVGRIqW |
| Chain | Residue | Details |
| A | ARG414-TRP421 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P29475","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"UniProtKB","id":"P29475","evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 3nos |
| Chain | Residue | Details |
| A | CYS415 | |
| A | TRP587 | |
| A | GLU592 | |
| A | ARG418 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 3nos |
| Chain | Residue | Details |
| B | CYS415 | |
| B | TRP587 | |
| B | GLU592 | |
| B | ARG418 | |
