Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3HQQ

Crystal structure of Leishmania mexicana pyruvate kinase (LmPYK) in complex with Fructose 2,6 bisphosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0004743	molecular_function	pyruvate kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006096	biological_process	glycolytic process
A	0016301	molecular_function	kinase activity
A	0030955	molecular_function	potassium ion binding
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0004743	molecular_function	pyruvate kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006096	biological_process	glycolytic process
B	0016301	molecular_function	kinase activity
B	0030955	molecular_function	potassium ion binding
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0004743	molecular_function	pyruvate kinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006096	biological_process	glycolytic process
C	0016301	molecular_function	kinase activity
C	0030955	molecular_function	potassium ion binding
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0004743	molecular_function	pyruvate kinase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006096	biological_process	glycolytic process
D	0016301	molecular_function	kinase activity
D	0030955	molecular_function	potassium ion binding
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0003824	molecular_function	catalytic activity
E	0004743	molecular_function	pyruvate kinase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0006096	biological_process	glycolytic process
E	0016301	molecular_function	kinase activity
E	0030955	molecular_function	potassium ion binding
E	0046872	molecular_function	metal ion binding
F	0000287	molecular_function	magnesium ion binding
F	0003824	molecular_function	catalytic activity
F	0004743	molecular_function	pyruvate kinase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0006096	biological_process	glycolytic process
F	0016301	molecular_function	kinase activity
F	0030955	molecular_function	potassium ion binding
F	0046872	molecular_function	metal ion binding
G	0000287	molecular_function	magnesium ion binding
G	0003824	molecular_function	catalytic activity
G	0004743	molecular_function	pyruvate kinase activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0006096	biological_process	glycolytic process
G	0016301	molecular_function	kinase activity
G	0030955	molecular_function	potassium ion binding
G	0046872	molecular_function	metal ion binding
H	0000287	molecular_function	magnesium ion binding
H	0003824	molecular_function	catalytic activity
H	0004743	molecular_function	pyruvate kinase activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0006096	biological_process	glycolytic process
H	0016301	molecular_function	kinase activity
H	0030955	molecular_function	potassium ion binding
H	0046872	molecular_function	metal ion binding
I	0000287	molecular_function	magnesium ion binding
I	0003824	molecular_function	catalytic activity
I	0004743	molecular_function	pyruvate kinase activity
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0006096	biological_process	glycolytic process
I	0016301	molecular_function	kinase activity
I	0030955	molecular_function	potassium ion binding
I	0046872	molecular_function	metal ion binding
J	0000287	molecular_function	magnesium ion binding
J	0003824	molecular_function	catalytic activity
J	0004743	molecular_function	pyruvate kinase activity
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0006096	biological_process	glycolytic process
J	0016301	molecular_function	kinase activity
J	0030955	molecular_function	potassium ion binding
J	0046872	molecular_function	metal ion binding
K	0000287	molecular_function	magnesium ion binding
K	0003824	molecular_function	catalytic activity
K	0004743	molecular_function	pyruvate kinase activity
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0006096	biological_process	glycolytic process
K	0016301	molecular_function	kinase activity
K	0030955	molecular_function	potassium ion binding
K	0046872	molecular_function	metal ion binding
L	0000287	molecular_function	magnesium ion binding
L	0003824	molecular_function	catalytic activity
L	0004743	molecular_function	pyruvate kinase activity
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0006096	biological_process	glycolytic process
L	0016301	molecular_function	kinase activity
L	0030955	molecular_function	potassium ion binding
L	0046872	molecular_function	metal ion binding
M	0000287	molecular_function	magnesium ion binding
M	0003824	molecular_function	catalytic activity
M	0004743	molecular_function	pyruvate kinase activity
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0006096	biological_process	glycolytic process
M	0016301	molecular_function	kinase activity
M	0030955	molecular_function	potassium ion binding
M	0046872	molecular_function	metal ion binding
N	0000287	molecular_function	magnesium ion binding
N	0003824	molecular_function	catalytic activity
N	0004743	molecular_function	pyruvate kinase activity
N	0005524	molecular_function	ATP binding
N	0005737	cellular_component	cytoplasm
N	0006096	biological_process	glycolytic process
N	0016301	molecular_function	kinase activity
N	0030955	molecular_function	potassium ion binding
N	0046872	molecular_function	metal ion binding
O	0000287	molecular_function	magnesium ion binding
O	0003824	molecular_function	catalytic activity
O	0004743	molecular_function	pyruvate kinase activity
O	0005524	molecular_function	ATP binding
O	0005737	cellular_component	cytoplasm
O	0006096	biological_process	glycolytic process
O	0016301	molecular_function	kinase activity
O	0030955	molecular_function	potassium ion binding
O	0046872	molecular_function	metal ion binding
P	0000287	molecular_function	magnesium ion binding
P	0003824	molecular_function	catalytic activity
P	0004743	molecular_function	pyruvate kinase activity
P	0005524	molecular_function	ATP binding
P	0005737	cellular_component	cytoplasm
P	0006096	biological_process	glycolytic process
P	0016301	molecular_function	kinase activity
P	0030955	molecular_function	potassium ion binding
P	0046872	molecular_function	metal ion binding
Q	0000287	molecular_function	magnesium ion binding
Q	0003824	molecular_function	catalytic activity
Q	0004743	molecular_function	pyruvate kinase activity
Q	0005524	molecular_function	ATP binding
Q	0005737	cellular_component	cytoplasm
Q	0006096	biological_process	glycolytic process
Q	0016301	molecular_function	kinase activity
Q	0030955	molecular_function	potassium ion binding
Q	0046872	molecular_function	metal ion binding
R	0000287	molecular_function	magnesium ion binding
R	0003824	molecular_function	catalytic activity
R	0004743	molecular_function	pyruvate kinase activity
R	0005524	molecular_function	ATP binding
R	0005737	cellular_component	cytoplasm
R	0006096	biological_process	glycolytic process
R	0016301	molecular_function	kinase activity
R	0030955	molecular_function	potassium ion binding
R	0046872	molecular_function	metal ion binding
S	0000287	molecular_function	magnesium ion binding
S	0003824	molecular_function	catalytic activity
S	0004743	molecular_function	pyruvate kinase activity
S	0005524	molecular_function	ATP binding
S	0005737	cellular_component	cytoplasm
S	0006096	biological_process	glycolytic process
S	0016301	molecular_function	kinase activity
S	0030955	molecular_function	potassium ion binding
S	0046872	molecular_function	metal ion binding
T	0000287	molecular_function	magnesium ion binding
T	0003824	molecular_function	catalytic activity
T	0004743	molecular_function	pyruvate kinase activity
T	0005524	molecular_function	ATP binding
T	0005737	cellular_component	cytoplasm
T	0006096	biological_process	glycolytic process
T	0016301	molecular_function	kinase activity
T	0030955	molecular_function	potassium ion binding
T	0046872	molecular_function	metal ion binding
U	0000287	molecular_function	magnesium ion binding
U	0003824	molecular_function	catalytic activity
U	0004743	molecular_function	pyruvate kinase activity
U	0005524	molecular_function	ATP binding
U	0005737	cellular_component	cytoplasm
U	0006096	biological_process	glycolytic process
U	0016301	molecular_function	kinase activity
U	0030955	molecular_function	potassium ion binding
U	0046872	molecular_function	metal ion binding
V	0000287	molecular_function	magnesium ion binding
V	0003824	molecular_function	catalytic activity
V	0004743	molecular_function	pyruvate kinase activity
V	0005524	molecular_function	ATP binding
V	0005737	cellular_component	cytoplasm
V	0006096	biological_process	glycolytic process
V	0016301	molecular_function	kinase activity
V	0030955	molecular_function	potassium ion binding
V	0046872	molecular_function	metal ion binding
W	0000287	molecular_function	magnesium ion binding
W	0003824	molecular_function	catalytic activity
W	0004743	molecular_function	pyruvate kinase activity
W	0005524	molecular_function	ATP binding
W	0005737	cellular_component	cytoplasm
W	0006096	biological_process	glycolytic process
W	0016301	molecular_function	kinase activity
W	0030955	molecular_function	potassium ion binding
W	0046872	molecular_function	metal ion binding
X	0000287	molecular_function	magnesium ion binding
X	0003824	molecular_function	catalytic activity
X	0004743	molecular_function	pyruvate kinase activity
X	0005524	molecular_function	ATP binding
X	0005737	cellular_component	cytoplasm
X	0006096	biological_process	glycolytic process
X	0016301	molecular_function	kinase activity
X	0030955	molecular_function	potassium ion binding
X	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00110
Number of Residues	13
Details	PYRUVATE_KINASE Pyruvate kinase active site signature. ImIICKIENhQGV

Chain	Residue	Details
A	ILE233-VAL245

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	216
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ARG49
B	ARG49
L	ARG49
L	ASN51
L	SER53
L	ASP83
L	THR84
L	GLU240
L	GLY263
L	ASP264
L	THR296
M	ARG49
B	ASN51
M	ASN51
M	SER53
M	ASP83
M	THR84
M	GLU240
M	GLY263
M	ASP264
M	THR296
N	ARG49
N	ASN51
B	SER53
N	SER53
N	ASP83
N	THR84
N	GLU240
N	GLY263
N	ASP264
N	THR296
O	ARG49
O	ASN51
O	SER53
B	ASP83
O	ASP83
O	THR84
O	GLU240
O	GLY263
O	ASP264
O	THR296
P	ARG49
P	ASN51
P	SER53
P	ASP83
B	THR84
P	THR84
P	GLU240
P	GLY263
P	ASP264
P	THR296
Q	ARG49
Q	ASN51
Q	SER53
Q	ASP83
Q	THR84
B	GLU240
Q	GLU240
Q	GLY263
Q	ASP264
Q	THR296
R	ARG49
R	ASN51
R	SER53
R	ASP83
R	THR84
R	GLU240
B	GLY263
R	GLY263
R	ASP264
R	THR296
S	ARG49
S	ASN51
S	SER53
S	ASP83
S	THR84
S	GLU240
S	GLY263
B	ASP264
S	ASP264
S	THR296
T	ARG49
T	ASN51
T	SER53
T	ASP83
T	THR84
T	GLU240
T	GLY263
T	ASP264
B	THR296
T	THR296
U	ARG49
U	ASN51
U	SER53
U	ASP83
U	THR84
U	GLU240
U	GLY263
U	ASP264
U	THR296
C	ARG49
V	ARG49
V	ASN51
V	SER53
V	ASP83
V	THR84
V	GLU240
V	GLY263
V	ASP264
V	THR296
W	ARG49
A	ASN51
C	ASN51
W	ASN51
W	SER53
W	ASP83
W	THR84
W	GLU240
W	GLY263
W	ASP264
W	THR296
X	ARG49
X	ASN51
C	SER53
X	SER53
X	ASP83
X	THR84
X	GLU240
X	GLY263
X	ASP264
X	THR296
C	ASP83
C	THR84
C	GLU240
C	GLY263
C	ASP264
C	THR296
D	ARG49
D	ASN51
A	SER53
D	SER53
D	ASP83
D	THR84
D	GLU240
D	GLY263
D	ASP264
D	THR296
E	ARG49
E	ASN51
E	SER53
A	ASP83
E	ASP83
E	THR84
E	GLU240
E	GLY263
E	ASP264
E	THR296
F	ARG49
F	ASN51
F	SER53
F	ASP83
A	THR84
F	THR84
F	GLU240
F	GLY263
F	ASP264
F	THR296
G	ARG49
G	ASN51
G	SER53
G	ASP83
G	THR84
A	GLU240
G	GLU240
G	GLY263
G	ASP264
G	THR296
H	ARG49
H	ASN51
H	SER53
H	ASP83
H	THR84
H	GLU240
A	GLY263
H	GLY263
H	ASP264
H	THR296
I	ARG49
I	ASN51
I	SER53
I	ASP83
I	THR84
I	GLU240
I	GLY263
A	ASP264
I	ASP264
I	THR296
J	ARG49
J	ASN51
J	SER53
J	ASP83
J	THR84
J	GLU240
J	GLY263
J	ASP264
A	THR296
J	THR296
K	ARG49
K	ASN51
K	SER53
K	ASP83
K	THR84
K	GLU240
K	GLY263
K	ASP264
K	THR296

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P14618

Chain	Residue	Details
A	ARG90
J	ARG90
K	ARG90
L	ARG90
M	ARG90
N	ARG90
O	ARG90
P	ARG90
Q	ARG90
R	ARG90
S	ARG90
B	ARG90
T	ARG90
U	ARG90
V	ARG90
W	ARG90
X	ARG90
C	ARG90
D	ARG90
E	ARG90
F	ARG90
G	ARG90
H	ARG90
I	ARG90

site_id	SWS_FT_FI3
Number of Residues	24
Details	SITE: Transition state stabilizer

Chain	Residue	Details
A	LYS238
J	LYS238
K	LYS238
L	LYS238
M	LYS238
N	LYS238
O	LYS238
P	LYS238
Q	LYS238
R	LYS238
S	LYS238
B	LYS238
T	LYS238
U	LYS238
V	LYS238
W	LYS238
X	LYS238
C	LYS238
D	LYS238
E	LYS238
F	LYS238
G	LYS238
H	LYS238
I	LYS238

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)