3HQQ

Crystal structure of Leishmania mexicana pyruvate kinase (LmPYK) in complex with Fructose 2,6 bisphosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0004743	molecular_function	pyruvate kinase activity
A	0005524	molecular_function	ATP binding
A	0006096	biological_process	glycolytic process
A	0006950	biological_process	response to stress
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0030955	molecular_function	potassium ion binding
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0004743	molecular_function	pyruvate kinase activity
B	0005524	molecular_function	ATP binding
B	0006096	biological_process	glycolytic process
B	0006950	biological_process	response to stress
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0030955	molecular_function	potassium ion binding
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0004743	molecular_function	pyruvate kinase activity
C	0005524	molecular_function	ATP binding
C	0006096	biological_process	glycolytic process
C	0006950	biological_process	response to stress
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0030955	molecular_function	potassium ion binding
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0004743	molecular_function	pyruvate kinase activity
D	0005524	molecular_function	ATP binding
D	0006096	biological_process	glycolytic process
D	0006950	biological_process	response to stress
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0030955	molecular_function	potassium ion binding
D	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0003824	molecular_function	catalytic activity
E	0004743	molecular_function	pyruvate kinase activity
E	0005524	molecular_function	ATP binding
E	0006096	biological_process	glycolytic process
E	0006950	biological_process	response to stress
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0030955	molecular_function	potassium ion binding
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0003824	molecular_function	catalytic activity
F	0004743	molecular_function	pyruvate kinase activity
F	0005524	molecular_function	ATP binding
F	0006096	biological_process	glycolytic process
F	0006950	biological_process	response to stress
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0030955	molecular_function	potassium ion binding
F	0046872	molecular_function	metal ion binding
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0003824	molecular_function	catalytic activity
G	0004743	molecular_function	pyruvate kinase activity
G	0005524	molecular_function	ATP binding
G	0006096	biological_process	glycolytic process
G	0006950	biological_process	response to stress
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0030955	molecular_function	potassium ion binding
G	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0003824	molecular_function	catalytic activity
H	0004743	molecular_function	pyruvate kinase activity
H	0005524	molecular_function	ATP binding
H	0006096	biological_process	glycolytic process
H	0006950	biological_process	response to stress
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity
H	0030955	molecular_function	potassium ion binding
H	0046872	molecular_function	metal ion binding
I	0000166	molecular_function	nucleotide binding
I	0000287	molecular_function	magnesium ion binding
I	0003824	molecular_function	catalytic activity
I	0004743	molecular_function	pyruvate kinase activity
I	0005524	molecular_function	ATP binding
I	0006096	biological_process	glycolytic process
I	0006950	biological_process	response to stress
I	0016301	molecular_function	kinase activity
I	0016740	molecular_function	transferase activity
I	0030955	molecular_function	potassium ion binding
I	0046872	molecular_function	metal ion binding
J	0000166	molecular_function	nucleotide binding
J	0000287	molecular_function	magnesium ion binding
J	0003824	molecular_function	catalytic activity
J	0004743	molecular_function	pyruvate kinase activity
J	0005524	molecular_function	ATP binding
J	0006096	biological_process	glycolytic process
J	0006950	biological_process	response to stress
J	0016301	molecular_function	kinase activity
J	0016740	molecular_function	transferase activity
J	0030955	molecular_function	potassium ion binding
J	0046872	molecular_function	metal ion binding
K	0000166	molecular_function	nucleotide binding
K	0000287	molecular_function	magnesium ion binding
K	0003824	molecular_function	catalytic activity
K	0004743	molecular_function	pyruvate kinase activity
K	0005524	molecular_function	ATP binding
K	0006096	biological_process	glycolytic process
K	0006950	biological_process	response to stress
K	0016301	molecular_function	kinase activity
K	0016740	molecular_function	transferase activity
K	0030955	molecular_function	potassium ion binding
K	0046872	molecular_function	metal ion binding
L	0000166	molecular_function	nucleotide binding
L	0000287	molecular_function	magnesium ion binding
L	0003824	molecular_function	catalytic activity
L	0004743	molecular_function	pyruvate kinase activity
L	0005524	molecular_function	ATP binding
L	0006096	biological_process	glycolytic process
L	0006950	biological_process	response to stress
L	0016301	molecular_function	kinase activity
L	0016740	molecular_function	transferase activity
L	0030955	molecular_function	potassium ion binding
L	0046872	molecular_function	metal ion binding
M	0000166	molecular_function	nucleotide binding
M	0000287	molecular_function	magnesium ion binding
M	0003824	molecular_function	catalytic activity
M	0004743	molecular_function	pyruvate kinase activity
M	0005524	molecular_function	ATP binding
M	0006096	biological_process	glycolytic process
M	0006950	biological_process	response to stress
M	0016301	molecular_function	kinase activity
M	0016740	molecular_function	transferase activity
M	0030955	molecular_function	potassium ion binding
M	0046872	molecular_function	metal ion binding
N	0000166	molecular_function	nucleotide binding
N	0000287	molecular_function	magnesium ion binding
N	0003824	molecular_function	catalytic activity
N	0004743	molecular_function	pyruvate kinase activity
N	0005524	molecular_function	ATP binding
N	0006096	biological_process	glycolytic process
N	0006950	biological_process	response to stress
N	0016301	molecular_function	kinase activity
N	0016740	molecular_function	transferase activity
N	0030955	molecular_function	potassium ion binding
N	0046872	molecular_function	metal ion binding
O	0000166	molecular_function	nucleotide binding
O	0000287	molecular_function	magnesium ion binding
O	0003824	molecular_function	catalytic activity
O	0004743	molecular_function	pyruvate kinase activity
O	0005524	molecular_function	ATP binding
O	0006096	biological_process	glycolytic process
O	0006950	biological_process	response to stress
O	0016301	molecular_function	kinase activity
O	0016740	molecular_function	transferase activity
O	0030955	molecular_function	potassium ion binding
O	0046872	molecular_function	metal ion binding
P	0000166	molecular_function	nucleotide binding
P	0000287	molecular_function	magnesium ion binding
P	0003824	molecular_function	catalytic activity
P	0004743	molecular_function	pyruvate kinase activity
P	0005524	molecular_function	ATP binding
P	0006096	biological_process	glycolytic process
P	0006950	biological_process	response to stress
P	0016301	molecular_function	kinase activity
P	0016740	molecular_function	transferase activity
P	0030955	molecular_function	potassium ion binding
P	0046872	molecular_function	metal ion binding
Q	0000166	molecular_function	nucleotide binding
Q	0000287	molecular_function	magnesium ion binding
Q	0003824	molecular_function	catalytic activity
Q	0004743	molecular_function	pyruvate kinase activity
Q	0005524	molecular_function	ATP binding
Q	0006096	biological_process	glycolytic process
Q	0006950	biological_process	response to stress
Q	0016301	molecular_function	kinase activity
Q	0016740	molecular_function	transferase activity
Q	0030955	molecular_function	potassium ion binding
Q	0046872	molecular_function	metal ion binding
R	0000166	molecular_function	nucleotide binding
R	0000287	molecular_function	magnesium ion binding
R	0003824	molecular_function	catalytic activity
R	0004743	molecular_function	pyruvate kinase activity
R	0005524	molecular_function	ATP binding
R	0006096	biological_process	glycolytic process
R	0006950	biological_process	response to stress
R	0016301	molecular_function	kinase activity
R	0016740	molecular_function	transferase activity
R	0030955	molecular_function	potassium ion binding
R	0046872	molecular_function	metal ion binding
S	0000166	molecular_function	nucleotide binding
S	0000287	molecular_function	magnesium ion binding
S	0003824	molecular_function	catalytic activity
S	0004743	molecular_function	pyruvate kinase activity
S	0005524	molecular_function	ATP binding
S	0006096	biological_process	glycolytic process
S	0006950	biological_process	response to stress
S	0016301	molecular_function	kinase activity
S	0016740	molecular_function	transferase activity
S	0030955	molecular_function	potassium ion binding
S	0046872	molecular_function	metal ion binding
T	0000166	molecular_function	nucleotide binding
T	0000287	molecular_function	magnesium ion binding
T	0003824	molecular_function	catalytic activity
T	0004743	molecular_function	pyruvate kinase activity
T	0005524	molecular_function	ATP binding
T	0006096	biological_process	glycolytic process
T	0006950	biological_process	response to stress
T	0016301	molecular_function	kinase activity
T	0016740	molecular_function	transferase activity
T	0030955	molecular_function	potassium ion binding
T	0046872	molecular_function	metal ion binding
U	0000166	molecular_function	nucleotide binding
U	0000287	molecular_function	magnesium ion binding
U	0003824	molecular_function	catalytic activity
U	0004743	molecular_function	pyruvate kinase activity
U	0005524	molecular_function	ATP binding
U	0006096	biological_process	glycolytic process
U	0006950	biological_process	response to stress
U	0016301	molecular_function	kinase activity
U	0016740	molecular_function	transferase activity
U	0030955	molecular_function	potassium ion binding
U	0046872	molecular_function	metal ion binding
V	0000166	molecular_function	nucleotide binding
V	0000287	molecular_function	magnesium ion binding
V	0003824	molecular_function	catalytic activity
V	0004743	molecular_function	pyruvate kinase activity
V	0005524	molecular_function	ATP binding
V	0006096	biological_process	glycolytic process
V	0006950	biological_process	response to stress
V	0016301	molecular_function	kinase activity
V	0016740	molecular_function	transferase activity
V	0030955	molecular_function	potassium ion binding
V	0046872	molecular_function	metal ion binding
W	0000166	molecular_function	nucleotide binding
W	0000287	molecular_function	magnesium ion binding
W	0003824	molecular_function	catalytic activity
W	0004743	molecular_function	pyruvate kinase activity
W	0005524	molecular_function	ATP binding
W	0006096	biological_process	glycolytic process
W	0006950	biological_process	response to stress
W	0016301	molecular_function	kinase activity
W	0016740	molecular_function	transferase activity
W	0030955	molecular_function	potassium ion binding
W	0046872	molecular_function	metal ion binding
X	0000166	molecular_function	nucleotide binding
X	0000287	molecular_function	magnesium ion binding
X	0003824	molecular_function	catalytic activity
X	0004743	molecular_function	pyruvate kinase activity
X	0005524	molecular_function	ATP binding
X	0006096	biological_process	glycolytic process
X	0006950	biological_process	response to stress
X	0016301	molecular_function	kinase activity
X	0016740	molecular_function	transferase activity
X	0030955	molecular_function	potassium ion binding
X	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00110
Number of Residues	13
Details	PYRUVATE_KINASE Pyruvate kinase active site signature. ImIICKIENhQGV

Chain	Residue	Details
A	ILE233-VAL245

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	216
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	96
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P14618","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Site: {"description":"Transition state stabilizer"}

Chain

Residue

Details

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