3HQN

Apo crystal structure of Leishmania mexicana(LmPYK)pyruvate kinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0004743	molecular_function	pyruvate kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006096	biological_process	glycolytic process
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0030955	molecular_function	potassium ion binding
A	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0004743	molecular_function	pyruvate kinase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006096	biological_process	glycolytic process
D	0016301	molecular_function	kinase activity
D	0016310	biological_process	phosphorylation
D	0030955	molecular_function	potassium ion binding
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL D 499

Chain	Residue
D	SER53
D	THR84
D	LYS85
D	SER211
D	LYS238
D	GLU240
D	K503
D	HOH782
D	HOH873

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 500

Chain	Residue
D	ASP232
D	ARG424
D	GLN426
D	THR427
D	GLN430

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 D 501

Chain	Residue
D	SER400
D	ASN401
D	THR402
D	ARG404
D	SER405
D	ASP482
D	HIS483
D	HOH619
D	HOH724
D	HOH801
D	HOH883

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K D 502

Chain	Residue
D	GLN354
D	LEU357
D	GLU359
D	HOH872

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K D 503

Chain	Residue
D	ASN51
D	SER53
D	ASP83
D	THR84
D	LYS238
D	GOL499
D	HOH873

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 499

Chain	Residue
A	GLU438
A	SER439
A	PHE463
A	HOH667
A	HOH724
A	HOH732
A	HOH734
A	HOH746

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 500

Chain	Residue
A	SER400
A	ASN401
A	THR402
A	ARG404
A	SER405
A	HOH815
A	HOH830

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K A 501

Chain	Residue
A	GLN354
A	LEU357
A	GLU359
A	HOH681
A	HOH797

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K A 502

Chain	Residue
A	ASN51
A	SER53
A	ASP83
A	THR84
A	HOH678

---

Functional Information from PROSITE/UniProt

site_id	PS00110
Number of Residues	13
Details	PYRUVATE_KINASE Pyruvate kinase active site signature. ImIICKIENhQGV

Chain	Residue	Details
D	ILE233-VAL245

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
D	ARG49
A	ARG49
A	ASN51
A	SER53
A	ASP83
A	THR84
A	GLU240
A	GLY263
A	ASP264
A	THR296
D	ASN51
D	SER53
D	ASP83
D	THR84
D	GLU240
D	GLY263
D	ASP264
D	THR296

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P14618

Chain	Residue	Details
D	ARG90
A	ARG90

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Transition state stabilizer

Chain	Residue	Details
D	LYS238
A	LYS238

---