3HQ1
Crystal structure of Mycobacterium tuberculosis LeuA complexed with citrate and Mn2+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003852 | molecular_function | 2-isopropylmalate synthase activity |
| A | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| A | 0009098 | biological_process | L-leucine biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0030955 | molecular_function | potassium ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003852 | molecular_function | 2-isopropylmalate synthase activity |
| B | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| B | 0009098 | biological_process | L-leucine biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0030955 | molecular_function | potassium ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 701 |
| Chain | Residue |
| A | ASP81 |
| A | HIS285 |
| A | HIS287 |
| A | ASN321 |
| A | HOH983 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 703 |
| Chain | Residue |
| A | GLY533 |
| A | LEU535 |
| B | ILE627 |
| B | GOL708 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 704 |
| Chain | Residue |
| A | ILE627 |
| B | GLY533 |
| B | PRO534 |
| B | LEU535 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 706 |
| Chain | Residue |
| A | PHE313 |
| A | ASN315 |
| A | VAL352 |
| A | ASN356 |
| A | LEU358 |
| A | PRO359 |
| A | HOH671 |
| A | HOH996 |
| B | HIS361 |
| B | ARG363 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 702 |
| Chain | Residue |
| B | ASP81 |
| B | HIS285 |
| B | HIS287 |
| B | FLC705 |
| B | HOH877 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE FLC B 705 |
| Chain | Residue |
| A | HIS379 |
| B | ARG80 |
| B | ASP81 |
| B | HIS167 |
| B | TYR169 |
| B | SER216 |
| B | GLU218 |
| B | ASN250 |
| B | PRO252 |
| B | THR254 |
| B | HIS285 |
| B | HIS287 |
| B | MN702 |
| B | HOH784 |
| B | HOH877 |
| B | HOH1059 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 707 |
| Chain | Residue |
| A | HIS361 |
| A | ARG363 |
| B | PHE313 |
| B | ASN315 |
| B | VAL352 |
| B | ASN356 |
| B | LEU358 |
| B | PRO359 |
| B | HOH680 |
| B | HOH868 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 708 |
| Chain | Residue |
| A | LEU535 |
| A | CL703 |
| B | ALA558 |
| B | ALA565 |
| B | GLN566 |
| B | ALA567 |
| B | PRO625 |
Functional Information from PROSITE/UniProt
| site_id | PS00815 |
| Number of Residues | 17 |
| Details | AIPM_HOMOCIT_SYNTH_1 Alpha-isopropylmalate and homocitrate synthases signature 1. LRDGnQalidPmsparK |
| Chain | Residue | Details |
| A | LEU79-LYS95 |
| site_id | PS00816 |
| Number of Residues | 14 |
| Details | AIPM_HOMOCIT_SYNTH_2 Alpha-isopropylmalate and homocitrate synthases signature 2. LslHpHNDrGtAvA |
| Chain | Residue | Details |
| A | LEU282-ALA295 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15159544, ECO:0000269|PubMed:22352945, ECO:0000312|PDB:1SR9, ECO:0000312|PDB:3U6W |
| Chain | Residue | Details |
| A | ARG80 | |
| A | THR254 | |
| B | ARG80 | |
| B | THR254 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00572, ECO:0000305|PubMed:15159544, ECO:0000305|PubMed:22352945, ECO:0007744|PDB:1SR9, ECO:0007744|PDB:3FIG, ECO:0007744|PDB:3HPS, ECO:0007744|PDB:3HPX, ECO:0007744|PDB:3HPZ, ECO:0007744|PDB:3HQ1, ECO:0007744|PDB:3U6W |
| Chain | Residue | Details |
| A | ASP81 | |
| A | HIS285 | |
| A | HIS287 | |
| B | ASP81 | |
| B | HIS285 | |
| B | HIS287 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00572, ECO:0000305|PubMed:22352945, ECO:0007744|PDB:3HPZ, ECO:0007744|PDB:3HQ1 |
| Chain | Residue | Details |
| A | ASN321 | |
| B | ASN321 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15159544, ECO:0000312|PDB:3FIG |
| Chain | Residue | Details |
| A | ASN532 | |
| B | ALA565 | |
| B | PRO625 | |
| B | ILE627 | |
| A | ALA536 | |
| A | ASP563 | |
| A | ALA565 | |
| A | PRO625 | |
| A | ILE627 | |
| B | ASN532 | |
| B | ALA536 | |
| B | ASP563 |
