Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016829 | molecular_function | lyase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0016829 | molecular_function | lyase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE GAE A 411 |
| Chain | Residue |
| A | ARG15 |
| A | PHE271 |
| A | THR296 |
| A | THR297 |
| A | GLN298 |
| A | ARG385 |
| A | HOH397 |
| A | HOH398 |
| A | MG401 |
| A | MG402 |
| A | HOH518 |
| A | ASP42 |
| A | HOH536 |
| A | HOH597 |
| A | HIS45 |
| A | TYR89 |
| A | ARG162 |
| A | TYR164 |
| A | ASP193 |
| A | GLU221 |
| A | HIS246 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 401 |
| Chain | Residue |
| A | ASP193 |
| A | GLU221 |
| A | HIS246 |
| A | HOH397 |
| A | GAE411 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 402 |
| Chain | Residue |
| A | ASP42 |
| A | HIS45 |
| A | THR297 |
| A | GAE411 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE GAE B 411 |
| Chain | Residue |
| B | ARG15 |
| B | ASP42 |
| B | HIS45 |
| B | TYR89 |
| B | ARG162 |
| B | TYR164 |
| B | ASP193 |
| B | GLU221 |
| B | HIS246 |
| B | PHE271 |
| B | THR296 |
| B | THR297 |
| B | GLN298 |
| B | ARG385 |
| B | MG401 |
| B | MG402 |
| B | HOH404 |
| B | HOH451 |
| B | HOH537 |
| B | HOH595 |
| B | HOH611 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 401 |
| Chain | Residue |
| B | ASP193 |
| B | GLU221 |
| B | HIS246 |
| B | HOH404 |
| B | GAE411 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 402 |
| Chain | Residue |
| B | ASP42 |
| B | HIS45 |
| B | THR297 |
| B | GAE411 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"19883118","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"19883118","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Increases basicity of active site Tyr"} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 9 |
| Details | M-CSA 502 |
| Chain | Residue | Details |
| A | ASP42 | metal ligand |
| A | HIS45 | metal ligand |
| A | PHE90 | proton acceptor, proton donor |
| A | ARG162 | electrostatic stabiliser, modifies pKa |
| A | TYR164 | proton acceptor, proton donor |
| A | ASP193 | metal ligand |
| A | GLU221 | metal ligand |
| A | HIS246 | metal ligand |
| A | THR297 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 9 |
| Details | M-CSA 502 |
| Chain | Residue | Details |
| B | ASP42 | metal ligand |
| B | HIS45 | metal ligand |
| B | PHE90 | proton acceptor, proton donor |
| B | ARG162 | electrostatic stabiliser, modifies pKa |
| B | TYR164 | proton acceptor, proton donor |
| B | ASP193 | metal ligand |
| B | GLU221 | metal ligand |
| B | HIS246 | metal ligand |
| B | THR297 | metal ligand |
