3HO6
Structure-function analysis of inositol hexakisphosphate-induced autoprocessing in clostridium difficile toxin A
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE IHP A 270 |
| Chain | Residue |
| A | TYR37 |
| A | HOH280 |
| A | HOH291 |
| A | HOH311 |
| A | HOH335 |
| A | HOH338 |
| A | HOH376 |
| A | HOH380 |
| A | HOH381 |
| A | HOH392 |
| A | HOH440 |
| A | LEU57 |
| A | HOH445 |
| A | HOH446 |
| A | HOH491 |
| A | HOH520 |
| A | HOH555 |
| A | HOH565 |
| A | HOH574 |
| A | LYS60 |
| A | LYS107 |
| A | ARG211 |
| A | LYS212 |
| A | LYS224 |
| A | LYS235 |
| A | LYS252 |
| site_id | AC2 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE IHP B 270 |
| Chain | Residue |
| A | ASN9 |
| B | TYR37 |
| B | LEU57 |
| B | LYS60 |
| B | LYS107 |
| B | ARG211 |
| B | LYS212 |
| B | LYS224 |
| B | LYS235 |
| B | LYS252 |
| B | HOH316 |
| B | HOH324 |
| B | HOH329 |
| B | HOH359 |
| B | HOH362 |
| B | HOH366 |
| B | HOH391 |
| B | HOH425 |
| B | HOH430 |
| B | HOH463 |
| B | HOH470 |
| B | HOH486 |
| B | HOH537 |
| B | HOH541 |
| B | HOH588 |
| B | HOH608 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19553670","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27571750","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile; for protease activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01107","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19553670","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27571750","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19553670","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HO6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27571750","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R04","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
