3HNC
Crystal structure of human ribonucleotide reductase 1 bound to the effector TTP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000731 | biological_process | DNA synthesis involved in DNA repair |
A | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005635 | cellular_component | nuclear envelope |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005829 | cellular_component | cytosol |
A | 0005971 | cellular_component | ribonucleoside-diphosphate reductase complex |
A | 0006206 | biological_process | pyrimidine nucleobase metabolic process |
A | 0006264 | biological_process | mitochondrial DNA replication |
A | 0006281 | biological_process | DNA repair |
A | 0008584 | biological_process | male gonad development |
A | 0009185 | biological_process | ribonucleoside diphosphate metabolic process |
A | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
A | 0009265 | biological_process | 2'-deoxyribonucleotide biosynthetic process |
A | 0010212 | biological_process | response to ionizing radiation |
A | 0010971 | biological_process | positive regulation of G2/M transition of mitotic cell cycle |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0017076 | molecular_function | purine nucleotide binding |
A | 0021846 | biological_process | cell proliferation in forebrain |
A | 0042802 | molecular_function | identical protein binding |
A | 0042995 | cellular_component | cell projection |
A | 0043025 | cellular_component | neuronal cell body |
A | 0051290 | biological_process | protein heterotetramerization |
A | 0060041 | biological_process | retina development in camera-type eye |
A | 0061731 | molecular_function | ribonucleoside-diphosphate reductase activity |
A | 0070318 | biological_process | positive regulation of G0 to G1 transition |
A | 0097718 | molecular_function | disordered domain specific binding |
A | 1900087 | biological_process | positive regulation of G1/S transition of mitotic cell cycle |
B | 0000731 | biological_process | DNA synthesis involved in DNA repair |
B | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005635 | cellular_component | nuclear envelope |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005829 | cellular_component | cytosol |
B | 0005971 | cellular_component | ribonucleoside-diphosphate reductase complex |
B | 0006206 | biological_process | pyrimidine nucleobase metabolic process |
B | 0006264 | biological_process | mitochondrial DNA replication |
B | 0006281 | biological_process | DNA repair |
B | 0008584 | biological_process | male gonad development |
B | 0009185 | biological_process | ribonucleoside diphosphate metabolic process |
B | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
B | 0009265 | biological_process | 2'-deoxyribonucleotide biosynthetic process |
B | 0010212 | biological_process | response to ionizing radiation |
B | 0010971 | biological_process | positive regulation of G2/M transition of mitotic cell cycle |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0017076 | molecular_function | purine nucleotide binding |
B | 0021846 | biological_process | cell proliferation in forebrain |
B | 0042802 | molecular_function | identical protein binding |
B | 0042995 | cellular_component | cell projection |
B | 0043025 | cellular_component | neuronal cell body |
B | 0051290 | biological_process | protein heterotetramerization |
B | 0060041 | biological_process | retina development in camera-type eye |
B | 0061731 | molecular_function | ribonucleoside-diphosphate reductase activity |
B | 0070318 | biological_process | positive regulation of G0 to G1 transition |
B | 0097718 | molecular_function | disordered domain specific binding |
B | 1900087 | biological_process | positive regulation of G1/S transition of mitotic cell cycle |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG A 801 |
Chain | Residue |
A | TTP802 |
A | HOH921 |
site_id | AC2 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE TTP A 802 |
Chain | Residue |
A | GLY264 |
A | SER269 |
A | ASN270 |
A | HOH793 |
A | MG801 |
A | HOH921 |
B | LYS243 |
B | TYR285 |
B | VAL286 |
B | ASP287 |
B | GLN288 |
B | GLY289 |
A | ASP226 |
A | SER227 |
A | ILE228 |
A | ILE231 |
A | ARG256 |
A | ILE262 |
A | ALA263 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 804 |
Chain | Residue |
A | ILE136 |
A | TYR137 |
A | ASP138 |
A | HOH982 |
B | LYS382 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 805 |
Chain | Residue |
A | SER687 |
A | GLN688 |
A | LYS689 |
site_id | AC5 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SO4 A 809 |
Chain | Residue |
A | ALA201 |
A | SER202 |
A | THR604 |
A | SER606 |
A | THR607 |
A | HOH826 |
A | HOH860 |
A | HOH892 |
A | HOH919 |
site_id | AC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG B 801 |
Chain | Residue |
B | TTP802 |
B | HOH919 |
site_id | AC7 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE TTP B 802 |
Chain | Residue |
A | LYS243 |
A | TYR285 |
A | VAL286 |
A | ASP287 |
A | GLN288 |
B | ASP226 |
B | SER227 |
B | ILE228 |
B | ILE231 |
B | ILE255 |
B | ARG256 |
B | ILE262 |
B | ALA263 |
B | GLY264 |
B | SER269 |
B | ASN270 |
B | HOH793 |
B | MG801 |
B | HOH805 |
B | HOH919 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B 803 |
Chain | Residue |
B | SER687 |
B | GLN688 |
B | LYS689 |
B | HOH873 |
B | HOH968 |
B | HOH969 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 806 |
Chain | Residue |
B | LYS5 |
B | ARG6 |
B | THR53 |
B | HOH970 |
site_id | BC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 B 807 |
Chain | Residue |
B | SER202 |
B | PRO603 |
B | THR604 |
B | ALA605 |
B | SER606 |
B | THR607 |
B | HOH956 |
Functional Information from PROSITE/UniProt
site_id | PS00089 |
Number of Residues | 23 |
Details | RIBORED_LARGE Ribonucleotide reductase large subunit signature. WkvLkekiakyGIRNsllIApmP |
Chain | Residue | Details |
A | TRP581-PRO603 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000250 |
Chain | Residue | Details |
A | ASN427 | |
A | GLU431 | |
B | ASN427 | |
B | GLU431 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Cysteine radical intermediate => ECO:0000250 |
Chain | Residue | Details |
A | CYS429 | |
B | CYS429 |
site_id | SWS_FT_FI3 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0007744|PDB:3HNE |
Chain | Residue | Details |
A | LYS5 | |
B | GLU11 | |
B | THR53 | |
B | ASP57 | |
B | ASP226 | |
B | LYS243 | |
B | ARG256 | |
B | ALA263 | |
A | GLU11 | |
A | THR53 | |
A | ASP57 | |
A | ASP226 | |
A | LYS243 | |
A | ARG256 | |
A | ALA263 | |
B | LYS5 |
site_id | SWS_FT_FI4 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0007744|PDB:3HND |
Chain | Residue | Details |
A | SER202 | |
B | THR604 | |
A | SER217 | |
A | ASN427 | |
A | GLU431 | |
A | THR604 | |
B | SER202 | |
B | SER217 | |
B | ASN427 | |
B | GLU431 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | SITE: Important for hydrogen atom transfer => ECO:0000250 |
Chain | Residue | Details |
A | CYS218 | |
A | CYS444 | |
B | CYS218 | |
B | CYS444 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | SITE: Important for electron transfer => ECO:0000250 |
Chain | Residue | Details |
A | TYR737 | |
A | TYR738 | |
B | TYR737 | |
B | TYR738 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | SITE: Interacts with thioredoxin/glutaredoxin => ECO:0000250 |
Chain | Residue | Details |
A | CYS787 | |
A | CYS790 | |
B | CYS787 | |
B | CYS790 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS17 | |
A | LYS376 | |
B | LYS17 | |
B | LYS376 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | THR751 | |
B | THR751 |