3HMQ

1.9 Angstrom resolution crystal structure of a NAD synthetase (nadE) from Salmonella typhimurium LT2 in complex with NAD(+)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003952	molecular_function	NAD+ synthase (glutamine-hydrolyzing) activity
A	0004359	molecular_function	glutaminase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0008795	molecular_function	NAD+ synthase activity
A	0009435	biological_process	NAD+ biosynthetic process
A	0016874	molecular_function	ligase activity
A	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 276

Chain	Residue
A	SER48
A	GLY50
A	ASP52
A	SER53
A	HOH385
A	HOH483
A	HOH547
A	HOH552
A	HOH610

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 277

Chain	Residue
A	TYR85
A	LYS138
A	ARG142
A	HOH523
A	HOH638

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 278

Chain	Residue
A	GLY50
A	GLN51
A	LYS189
A	HOH425
A	HOH446
A	HOH547

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 279

Chain	Residue
A	TYR85
A	ARG134
A	LYS138
A	HOH292
A	HOH452
A	HOH475

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 280

Chain	Residue
A	NAD300
A	HOH549
A	HOH704

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 281

Chain	Residue
A	ASP271
A	PHE272
A	HOH461
A	HOH522

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 282

Chain	Residue
A	GLY86
A	VAL87
A	LYS112
A	HOH497

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 283

Chain	Residue
A	THR2
A	LEU3
A	HOH519
A	HOH686

---

site_id	AC9
Number of Residues	30
Details	BINDING SITE FOR RESIDUE NAD A 300

Chain	Residue
A	TYR33
A	GLU70
A	PHE132
A	ASN136
A	ARG140
A	TYR147
A	ALA150
A	GLY151
A	GLY155
A	VAL156
A	PHE170
A	PHE171
A	THR172
A	LYS173
A	ASP180
A	ALA225
A	TRP254
A	HIS260
A	LYS261
A	SO4280
A	HOH337
A	HOH438
A	HOH508
A	HOH565
A	HOH586
A	HOH628
A	HOH655
A	HOH665
A	HOH672
A	HOH684

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"MAY-2009","submissionDatabase":"PDB data bank","title":"1.9 Angstrom resolution crystal structure of a NAD synthetase (nadE) from Salmonella typhimurium LT2 in complex with NAD(+).","authors":["Halavaty A.S.","Wawrzak Z.","Skarina T.","Onopriyenko O.","Peterson S.N.","Savchenko A.","Anderson W.F."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00193","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00193","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"MAY-2009","submissionDatabase":"PDB data bank","title":"1.9 Angstrom resolution crystal structure of a NAD synthetase (nadE) from Salmonella typhimurium LT2 in complex with NAD(+).","authors":["Halavaty A.S.","Wawrzak Z.","Skarina T.","Onopriyenko O.","Peterson S.N.","Savchenko A.","Anderson W.F."]}}]}

Chain

Residue

Details

---