3HLF

Simvastatin Synthase (LovD), from Aspergillus terreus, S5 mutant, S76A mutant, complex with simvastatin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016218	molecular_function	polyketide synthase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0017000	biological_process	antibiotic biosynthetic process
A	0030639	biological_process	polyketide biosynthetic process
A	0050832	biological_process	defense response to fungus
A	0140735	biological_process	lovastatin biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SIM A 500

Chain	Residue
A	ALA75
A	GLU388
A	HOH432
A	HOH472
A	ALA76
A	TYR146
A	ARG173
A	TYR188
A	TYR258
A	GLN270
A	ILE325
A	GLY366

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Acyl-ester intermediate => ECO:0000269|PubMed:17113998, ECO:0000269|PubMed:19875080

Chain	Residue	Details
A	ALA76

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site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING:

Chain	Residue	Details
A	ARG73
A	ARG173
A	TYR188
A	TYR258
A	GLY366
A	GLU388
A	TRP390

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