3HLF
Simvastatin Synthase (LovD), from Aspergillus terreus, S5 mutant, S76A mutant, complex with simvastatin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017000 | biological_process | antibiotic biosynthetic process |
| A | 0030639 | biological_process | polyketide biosynthetic process |
| A | 0050832 | biological_process | defense response to fungus |
| A | 0140735 | biological_process | lovastatin biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SIM A 500 |
| Chain | Residue |
| A | ALA75 |
| A | GLU388 |
| A | HOH432 |
| A | HOH472 |
| A | ALA76 |
| A | TYR146 |
| A | ARG173 |
| A | TYR188 |
| A | TYR258 |
| A | GLN270 |
| A | ILE325 |
| A | GLY366 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"17113998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19875080","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {} |
| Chain | Residue | Details |
