3HLD
Simvastatin Synthase (LovD), from Aspergillus terreus, S5 mutant complex with monacolin J acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017000 | biological_process | antibiotic biosynthetic process |
| A | 0030639 | biological_process | polyketide biosynthetic process |
| A | 0050832 | biological_process | defense response to fungus |
| A | 0140735 | biological_process | lovastatin biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE MJA A 501 |
| Chain | Residue |
| A | ARG73 |
| A | TRP390 |
| A | FMT414 |
| A | MJA502 |
| A | HOH513 |
| A | HOH586 |
| A | HOH682 |
| A | SER76 |
| A | PHE148 |
| A | ARG173 |
| A | TYR188 |
| A | TYR258 |
| A | TYR327 |
| A | GLY366 |
| A | GLU388 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MJA A 502 |
| Chain | Residue |
| A | ARG103 |
| A | PHE148 |
| A | ARG201 |
| A | MJA501 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT A 414 |
| Chain | Residue |
| A | ALA75 |
| A | SER76 |
| A | GLY366 |
| A | MJA501 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT A 415 |
| Chain | Residue |
| A | ASP262 |
| A | PHE267 |
| A | GLN270 |
| A | GLY271 |
| A | HOH575 |
| A | HOH600 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE FMT A 416 |
| Chain | Residue |
| A | ASN45 |
| A | TYR46 |
| A | THR47 |
| A | ARG48 |
| A | ASN60 |
| A | ASN61 |
| A | GLN62 |
| A | HOH461 |
| A | HOH608 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT A 417 |
| Chain | Residue |
| A | ARG73 |
| A | TYR258 |
| A | GLN270 |
| A | HOH584 |
| A | HOH682 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"17113998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19875080","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {} |
| Chain | Residue | Details |
