3HLC

Simvastatin Synthase (LovD) from Aspergillus terreus, S5 mutant, unliganded

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016746	molecular_function	acyltransferase activity
A	0017000	biological_process	antibiotic biosynthetic process
A	0030639	biological_process	polyketide biosynthetic process
A	0050832	biological_process	defense response to fungus
A	0140735	biological_process	lovastatin biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 414

Chain	Residue
A	PRO323
A	MET331
A	MET333
A	ARG396

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PG4 A 415

Chain	Residue
A	PHE363
A	GLY364
A	TRP390
A	HOH446
A	TYR146
A	PHE148
A	GLN270
A	ILE325
A	TYR327

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"17113998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19875080","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {}

Chain

Residue

Details

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