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3HL9

Simvastatin Synthase (LovD) from Aspergillus terreus, unliganded

Functional Information from GO Data
ChainGOidnamespacecontents
A0016218molecular_functionpolyketide synthase activity
A0016746molecular_functionacyltransferase activity
A0016787molecular_functionhydrolase activity
A0017000biological_processantibiotic biosynthetic process
A0030639biological_processpolyketide biosynthetic process
A0050832biological_processdefense response to fungus
A0140735biological_processlovastatin biosynthetic process
B0016218molecular_functionpolyketide synthase activity
B0016746molecular_functionacyltransferase activity
B0016787molecular_functionhydrolase activity
B0017000biological_processantibiotic biosynthetic process
B0030639biological_processpolyketide biosynthetic process
B0050832biological_processdefense response to fungus
B0140735biological_processlovastatin biosynthetic process
C0016218molecular_functionpolyketide synthase activity
C0016746molecular_functionacyltransferase activity
C0016787molecular_functionhydrolase activity
C0017000biological_processantibiotic biosynthetic process
C0030639biological_processpolyketide biosynthetic process
C0050832biological_processdefense response to fungus
C0140735biological_processlovastatin biosynthetic process
D0016218molecular_functionpolyketide synthase activity
D0016746molecular_functionacyltransferase activity
D0016787molecular_functionhydrolase activity
D0017000biological_processantibiotic biosynthetic process
D0030639biological_processpolyketide biosynthetic process
D0050832biological_processdefense response to fungus
D0140735biological_processlovastatin biosynthetic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Acyl-ester intermediate => ECO:0000269|PubMed:17113998, ECO:0000269|PubMed:19875080
ChainResidueDetails
ASER76
BSER76
CSER76
DSER76

site_idSWS_FT_FI2
Number of Residues28
DetailsBINDING:
ChainResidueDetails
AARG73
BTYR188
BTYR258
BGLY366
BGLU388
BTRP390
CARG73
CARG173
CTYR188
CTYR258
CGLY366
AARG173
CGLU388
CTRP390
DARG73
DARG173
DTYR188
DTYR258
DGLY366
DGLU388
DTRP390
ATYR188
ATYR258
AGLY366
AGLU388
ATRP390
BARG73
BARG173

219140

PDB entries from 2024-05-01

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