3HJB
1.5 Angstrom Crystal Structure of Glucose-6-phosphate Isomerase from Vibrio cholerae.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004347 | molecular_function | glucose-6-phosphate isomerase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0048029 | molecular_function | monosaccharide binding |
| A | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| A | 0097367 | molecular_function | carbohydrate derivative binding |
| A | 1901135 | biological_process | carbohydrate derivative metabolic process |
| B | 0004347 | molecular_function | glucose-6-phosphate isomerase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0048029 | molecular_function | monosaccharide binding |
| B | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| B | 0097367 | molecular_function | carbohydrate derivative binding |
| B | 1901135 | biological_process | carbohydrate derivative metabolic process |
| C | 0004347 | molecular_function | glucose-6-phosphate isomerase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006094 | biological_process | gluconeogenesis |
| C | 0006096 | biological_process | glycolytic process |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0048029 | molecular_function | monosaccharide binding |
| C | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| C | 0097367 | molecular_function | carbohydrate derivative binding |
| C | 1901135 | biological_process | carbohydrate derivative metabolic process |
| D | 0004347 | molecular_function | glucose-6-phosphate isomerase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006094 | biological_process | gluconeogenesis |
| D | 0006096 | biological_process | glycolytic process |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0048029 | molecular_function | monosaccharide binding |
| D | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| D | 0097367 | molecular_function | carbohydrate derivative binding |
| D | 1901135 | biological_process | carbohydrate derivative metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 551 |
| Chain | Residue |
| A | GLU62 |
| A | HOH812 |
| A | HOH921 |
| A | HOH2078 |
| A | HOH2216 |
| A | HOH3413 |
| C | HOH2469 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 552 |
| Chain | Residue |
| A | HOH2765 |
| A | HOH2918 |
| A | HOH3926 |
| A | GLU168 |
| A | HOH1387 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 553 |
| Chain | Residue |
| A | GLU253 |
| A | HOH3373 |
| A | HOH3833 |
| A | HOH3984 |
| A | HOH4115 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 554 |
| Chain | Residue |
| A | GLU332 |
| A | HOH3970 |
| B | GLY330 |
| B | CA552 |
| B | HOH4111 |
| B | HOH4114 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 555 |
| Chain | Residue |
| A | ARG95 |
| A | ALA96 |
| A | HOH1640 |
| A | HOH2031 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 556 |
| Chain | Residue |
| A | ASN327 |
| A | TYR371 |
| A | GLN372 |
| A | HOH1459 |
| A | HOH1928 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 557 |
| Chain | Residue |
| A | LYS127 |
| A | MET261 |
| A | GLU263 |
| A | HOH1040 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 558 |
| Chain | Residue |
| A | GLN419 |
| A | HOH598 |
| B | ARG549 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 559 |
| Chain | Residue |
| A | ASN175 |
| A | GLY287 |
| A | HOH1053 |
| A | HOH1302 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 560 |
| Chain | Residue |
| A | MET26 |
| A | ASP27 |
| A | HOH2211 |
| A | HOH2711 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 561 |
| Chain | Residue |
| A | ALA452 |
| A | HOH2855 |
| site_id | BC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PG4 A 562 |
| Chain | Residue |
| A | GLN24 |
| A | ASP25 |
| A | GLY396 |
| A | THR397 |
| A | LYS398 |
| A | LEU399 |
| A | ASN467 |
| A | ARG468 |
| A | HOH2008 |
| A | HOH2467 |
| A | HOH2504 |
| A | HOH3493 |
| B | PEG561 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 551 |
| Chain | Residue |
| B | GLU62 |
| B | HOH638 |
| B | HOH651 |
| B | HOH1182 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 552 |
| Chain | Residue |
| A | GLY330 |
| A | CA554 |
| A | HOH3970 |
| A | HOH3971 |
| B | GLU332 |
| B | HOH4111 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B 553 |
| Chain | Residue |
| B | ARG95 |
| B | ALA96 |
| B | TRP267 |
| B | HOH1188 |
| B | HOH1869 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 554 |
| Chain | Residue |
| B | ASN175 |
| B | GLY287 |
| B | HOH731 |
| B | HOH1657 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 555 |
| Chain | Residue |
| B | ASN327 |
| B | TYR371 |
| B | GLN372 |
| B | HOH2282 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B 556 |
| Chain | Residue |
| B | ASP266 |
| B | HOH1729 |
| B | HOH1869 |
| B | HOH3152 |
| B | HOH3651 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL B 557 |
| Chain | Residue |
| B | ASN104 |
| B | ASN107 |
| B | MET118 |
| B | ASN122 |
| B | HOH596 |
| B | HOH3987 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL B 558 |
| Chain | Residue |
| B | PHE310 |
| B | HOH1482 |
| B | HOH2632 |
| B | LYS72 |
| B | LEU76 |
| B | GLN77 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL B 559 |
| Chain | Residue |
| A | PHE32 |
| A | HOH890 |
| B | ASP535 |
| B | SER536 |
| B | HOH658 |
| B | HOH1354 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 560 |
| Chain | Residue |
| B | HOH720 |
| B | HOH1465 |
| B | HOH1875 |
| B | HOH2002 |
| B | HOH3986 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 561 |
| Chain | Residue |
| A | PG4562 |
| B | TYR371 |
| B | GLN372 |
| B | HOH1094 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA C 551 |
| Chain | Residue |
| C | GLU62 |
| C | HOH617 |
| C | HOH734 |
| C | HOH1246 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 552 |
| Chain | Residue |
| C | ARG95 |
| C | ALA96 |
| C | TRP267 |
| C | HOH1993 |
| site_id | CC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 553 |
| Chain | Residue |
| C | ASN175 |
| C | GLY287 |
| C | HOH636 |
| site_id | CC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 554 |
| Chain | Residue |
| C | ARG549 |
| D | GLN419 |
| D | HOH580 |
| D | HOH714 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 555 |
| Chain | Residue |
| C | ASN327 |
| C | TYR371 |
| C | GLN372 |
| C | HOH1846 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL C 556 |
| Chain | Residue |
| C | SER410 |
| C | ASN412 |
| C | HOH624 |
| C | HOH1255 |
| D | GLY187 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA C 557 |
| Chain | Residue |
| C | HOH651 |
| C | HOH1214 |
| C | HOH1811 |
| C | HOH3215 |
| C | HOH3913 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG C 558 |
| Chain | Residue |
| B | ARG105 |
| B | SER106 |
| B | ASN107 |
| C | LYS450 |
| C | HOH1379 |
| C | HOH2803 |
| site_id | DC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PEG C 559 |
| Chain | Residue |
| B | ALA448 |
| B | LYS450 |
| B | HOH1842 |
| C | ARG105 |
| C | SER106 |
| C | ASN107 |
| C | HOH1326 |
| C | HOH2774 |
| C | HOH2888 |
| C | HOH3994 |
| site_id | DC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG C 560 |
| Chain | Residue |
| C | VAL369 |
| C | TYR371 |
| C | GLN372 |
| C | HOH818 |
| D | THR397 |
| D | PG4561 |
| site_id | DC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 551 |
| Chain | Residue |
| B | HOH2124 |
| D | GLU62 |
| D | HOH811 |
| D | HOH830 |
| D | HOH2011 |
| D | HOH2302 |
| site_id | DC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 552 |
| Chain | Residue |
| D | GLU168 |
| D | HOH1444 |
| D | HOH1506 |
| D | HOH2839 |
| D | HOH3927 |
| D | HOH3928 |
| site_id | DC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 553 |
| Chain | Residue |
| D | GLU253 |
| D | HOH2802 |
| D | HOH3337 |
| D | HOH3881 |
| D | HOH3930 |
| D | HOH3985 |
| site_id | EC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL D 554 |
| Chain | Residue |
| D | ARG95 |
| D | ALA96 |
| D | HOH1885 |
| D | HOH2032 |
| site_id | EC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL D 555 |
| Chain | Residue |
| D | ASN327 |
| D | TYR371 |
| D | GLN372 |
| D | HOH1477 |
| D | HOH1656 |
| site_id | EC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL D 556 |
| Chain | Residue |
| D | ASN175 |
| D | GLY287 |
| D | HOH1031 |
| D | HOH1418 |
| D | HOH3873 |
| site_id | EC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL D 557 |
| Chain | Residue |
| D | LYS127 |
| D | MET261 |
| D | GLU263 |
| site_id | EC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL D 558 |
| Chain | Residue |
| D | MET26 |
| D | ASP27 |
| D | HOH2120 |
| D | HOH3226 |
| D | HOH3709 |
| site_id | EC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL D 559 |
| Chain | Residue |
| D | ILE89 |
| D | PHE506 |
| D | HOH565 |
| D | HOH574 |
| site_id | EC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL D 560 |
| Chain | Residue |
| D | ALA452 |
| D | HOH2046 |
| site_id | EC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PG4 D 561 |
| Chain | Residue |
| C | PEG560 |
| D | GLN24 |
| D | GLY396 |
| D | THR397 |
| D | LEU399 |
| D | ASN467 |
| D | ARG468 |
| D | HOH1814 |
| D | HOH1882 |
| D | HOH2122 |
| D | HOH2505 |
| D | HOH3887 |
Functional Information from PROSITE/UniProt
| site_id | PS00174 |
| Number of Residues | 18 |
| Details | P_GLUCOSE_ISOMERASE_2 Phosphoglucose isomerase signature 2. GvIWnifsFDQwGVElgK |
| Chain | Residue | Details |
| A | GLY498-LYS515 |
| site_id | PS00765 |
| Number of Residues | 14 |
| Details | P_GLUCOSE_ISOMERASE_1 Phosphoglucose isomerase signature 1. DwVGGRYSLwSAIG |
| Chain | Residue | Details |
| A | ASP266-GLY279 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00473 |
| Chain | Residue | Details |
| A | GLU356 | |
| B | GLU356 | |
| C | GLU356 | |
| D | GLU356 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00473 |
| Chain | Residue | Details |
| A | HIS387 | |
| A | LYS515 | |
| B | HIS387 | |
| B | LYS515 | |
| C | HIS387 | |
| C | LYS515 | |
| D | HIS387 | |
| D | LYS515 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| A | GLU215 | |
| A | GLU356 | |
| A | LYS209 | |
| A | GLY270 | |
| A | LYS515 | |
| A | ARG271 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| B | GLU215 | |
| B | GLU356 | |
| B | LYS209 | |
| B | GLY270 | |
| B | LYS515 | |
| B | ARG271 |
| site_id | CSA3 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| C | GLU215 | |
| C | GLU356 | |
| C | LYS209 | |
| C | GLY270 | |
| C | LYS515 | |
| C | ARG271 |
| site_id | CSA4 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| D | GLU215 | |
| D | GLU356 | |
| D | LYS209 | |
| D | GLY270 | |
| D | LYS515 | |
| D | ARG271 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| A | HIS387 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| B | HIS387 |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| C | HIS387 |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| D | HIS387 |
