3H9V
Crystal structure of the ATP-gated P2X4 ion channel in the closed, apo state at 3.1 Angstroms
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001614 | molecular_function | purinergic nucleotide receptor activity |
| A | 0002135 | molecular_function | CTP binding |
| A | 0004931 | molecular_function | extracellularly ATP-gated monoatomic cation channel activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0007165 | biological_process | signal transduction |
| A | 0015267 | molecular_function | channel activity |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0017076 | molecular_function | purine nucleotide binding |
| A | 0033198 | biological_process | response to ATP |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0035381 | molecular_function | ATP-gated ion channel activity |
| A | 0035590 | biological_process | purinergic nucleotide receptor signaling pathway |
| A | 0060079 | biological_process | excitatory postsynaptic potential |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| A | 0098794 | cellular_component | postsynapse |
| A | 1902495 | cellular_component | transmembrane transporter complex |
Functional Information from PROSITE/UniProt
| site_id | PS01212 |
| Number of Residues | 27 |
| Details | P2X_RECEPTOR ATP P2X receptors signature. GGvMGVqIrWdCDLDmpqswCvPrYtF |
| Chain | Residue | Details |
| A | GLY253-PHE279 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical => ECO:0000305|PubMed:28332633, ECO:0007744|PDB:5WZY |
| Chain | Residue | Details |
| A | PHE37-TYR57 | |
| A | ALA344-MET364 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 285 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:28332633, ECO:0007744|PDB:5WZY |
| Chain | Residue | Details |
| A | GLN58-GLY343 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28332633, ECO:0007744|PDB:5WZY |
| Chain | Residue | Details |
| A | LYS70 | |
| A | LYS72 | |
| A | ARG143 | |
| A | THR189 | |
| A | ASN296 | |
| A | ARG298 | |
| A | LYS316 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22535247, ECO:0007744|PDB:4DW1 |
| Chain | Residue | Details |
| A | LEU191 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19641588, ECO:0000312|PDB:3I5D |
| Chain | Residue | Details |
| A | LYS78 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19641588, ECO:0000269|PubMed:22535247, ECO:0007744|PDB:3H9V, ECO:0007744|PDB:3I5D, ECO:0007744|PDB:4DW0, ECO:0007744|PDB:4DW1, ECO:0007744|PDB:5WZY |
| Chain | Residue | Details |
| A | ASN113 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19641588, ECO:0007744|PDB:3I5D |
| Chain | Residue | Details |
| A | ARG187 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19641588, ECO:0007744|PDB:3I5D, ECO:0007744|PDB:4DW0, ECO:0007744|PDB:4DW1 |
| Chain | Residue | Details |
| A | ASN213 |
