3H99

Structure of a mutant methionyl-tRNA synthetase with modified specificity complexed with methionine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004825	molecular_function	methionine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006431	biological_process	methionyl-tRNA aminoacylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE MET A 602

Chain	Residue
A	SER13
A	HOH1469
A	HOH1489
A	HOH1506
A	HOH1938
A	TYR15
A	ASP52
A	TRP253
A	ALA256
A	PRO257
A	ILE297
A	HOH1442
A	HOH1462

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 601

Chain	Residue
A	CYS145
A	CYS148
A	CYS158
A	VAL160
A	CYS161

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CIT A 603

Chain	Residue
A	PRO137
A	ASP138
A	ARG233
A	HOH1436
A	HOH1463
A	HOH1480
A	HOH1495
A	HOH1520
A	HOH1536
A	HOH1589
A	HOH1929
A	HOH1932
A	HOH1940

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CIT A 604

Chain	Residue
A	GLN63
A	LYS132
A	HOH1568
A	HOH1586
A	HOH1596
A	HOH1606
A	HOH1662
A	HOH1663
A	HOH1978
A	HOH2012

---

Functional Information from PROSITE/UniProt

site_id	PS00178
Number of Residues	12
Details	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PyaNGsIHLGHM

Chain	Residue	Details
A	PRO14-MET25

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Motif: {"description":"'HIGH' region","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Motif: {"description":"'KMSKS' region","evidences":[{"source":"PubMed","id":"7932711","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11243794","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12946347","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PG2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10600385","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11243794","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12946347","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8515465","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8515466","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MEA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MED","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P7P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PFV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PFY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QQT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"2254937","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a8h

Chain	Residue	Details
A	LYS335
A	LYS332

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1a8h

Chain	Residue	Details
A	LYS335

---