3H81
Crystal structure of enoyl-CoA hydratase from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004300 | molecular_function | enoyl-CoA hydratase activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006635 | biological_process | fatty acid beta-oxidation |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016836 | molecular_function | hydro-lyase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004300 | molecular_function | enoyl-CoA hydratase activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006635 | biological_process | fatty acid beta-oxidation |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016836 | molecular_function | hydro-lyase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004300 | molecular_function | enoyl-CoA hydratase activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006631 | biological_process | fatty acid metabolic process |
| C | 0006635 | biological_process | fatty acid beta-oxidation |
| C | 0009274 | cellular_component | peptidoglycan-based cell wall |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016836 | molecular_function | hydro-lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 401 |
| Chain | Residue |
| A | ALA86 |
| A | MET91 |
| A | PHE105 |
| A | GLU132 |
| A | LEU158 |
| A | GLY160 |
| A | MET161 |
| A | HOH327 |
| A | HOH351 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 279 |
| Chain | Residue |
| A | PHE255 |
| A | GLN260 |
| A | HOH306 |
| A | HOH311 |
| C | LEU94 |
| C | HOH325 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 401 |
| Chain | Residue |
| B | ALA86 |
| B | GLU132 |
| B | GLU152 |
| B | LEU158 |
| B | PRO159 |
| B | GLY160 |
| B | MET161 |
| B | HOH343 |
| B | HOH362 |
| C | PHE251 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL C 401 |
| Chain | Residue |
| A | PHE251 |
| C | ALA86 |
| C | PHE105 |
| C | GLU132 |
| C | GLU152 |
| C | LEU158 |
| C | PRO159 |
| C | GLY160 |
| C | MET161 |
| C | HOH304 |
| C | HOH359 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL C 402 |
| Chain | Residue |
| C | PHE105 |
| C | TRP108 |
| C | ALA112 |
| C | MET136 |
| C | MET161 |
| C | ARG166 |
| C | HOH300 |
| C | HOH380 |
| C | HOH561 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 279 |
| Chain | Residue |
| A | ARG193 |
| A | HOH377 |
| B | ARG193 |
| B | HOH307 |
| C | ARG193 |
| C | HOH355 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 280 |
| Chain | Residue |
| B | LEU94 |
| B | HOH315 |
| B | HOH337 |
| C | PHE255 |
| C | GLN260 |
| C | HOH353 |
Functional Information from PROSITE/UniProt
| site_id | PS00166 |
| Number of Residues | 21 |
| Details | ENOYL_COA_HYDRATASE Enoyl-CoA hydratase/isomerase signature. IAaVAGyalGGGcelaMmCDV |
| Chain | Residue | Details |
| A | ILE119-VAL139 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dub |
| Chain | Residue | Details |
| A | GLU152 | |
| A | ALA86 | |
| A | GLY129 | |
| A | GLU132 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dub |
| Chain | Residue | Details |
| B | GLU152 | |
| B | ALA86 | |
| B | GLY129 | |
| B | GLU132 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dub |
| Chain | Residue | Details |
| C | GLU152 | |
| C | ALA86 | |
| C | GLY129 | |
| C | GLU132 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dub |
| Chain | Residue | Details |
| A | GLU152 | |
| A | GLY160 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dub |
| Chain | Residue | Details |
| B | GLU152 | |
| B | GLY160 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dub |
| Chain | Residue | Details |
| C | GLU152 | |
| C | GLY160 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dub |
| Chain | Residue | Details |
| A | GLU152 | |
| A | GLY129 | |
| A | GLU132 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dub |
| Chain | Residue | Details |
| B | GLU152 | |
| B | GLY129 | |
| B | GLU132 |
| site_id | CSA9 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dub |
| Chain | Residue | Details |
| C | GLU152 | |
| C | GLY129 | |
| C | GLU132 |
