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3H5Q

Crystal structure of a putative pyrimidine-nucleoside phosphorylase from Staphylococcus aureus

Functional Information from GO Data
ChainGOidnamespacecontents
A0004645molecular_function1,4-alpha-oligoglucan phosphorylase activity
A0004850molecular_functionuridine phosphorylase activity
A0005829cellular_componentcytosol
A0006206biological_processpyrimidine nucleobase metabolic process
A0006213biological_processpyrimidine nucleoside metabolic process
A0009032molecular_functionthymidine phosphorylase activity
A0016154molecular_functionpyrimidine-nucleoside phosphorylase activity
A0016757molecular_functionglycosyltransferase activity
A0016763molecular_functionpentosyltransferase activity
A0046872molecular_functionmetal ion binding
A0047847molecular_functiondeoxyuridine phosphorylase activity
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE THM A 434
ChainResidue
ATYR165
AARG168
AILE180
ASER183
ALYS187
APHE207
AHOH698

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 435
ChainResidue
ALYS266
AASP267
AHOH442
AHOH538
AHOH690
AHOH756
AARG245
APRO265

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 436
ChainResidue
ATHR92
ALYS108
ASER110
ATHR120
AHOH616
AHOH699

Functional Information from PROSITE/UniProt
site_idPS00647
Number of Residues16
DetailsTHYMID_PHOSPHORYLASE Thymidine and pyrimidine-nucleoside phosphorylases signature. SGRGLghTGGTiDkLE
ChainResidueDetails
ASER110-GLU125

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues11
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P77836
ChainResidueDetails
ALYS81
AALA246
AGLU255
AGLY88
ATHR90
ATHR92
ALYS108
ATHR120
AARG168
ALYS187
ALEU243

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1azy
ChainResidueDetails
ALYS187
AHIS82
AARG168

site_idCSA2
Number of Residues4
DetailsAnnotated By Reference To The Literature 1azy
ChainResidueDetails
ALYS187
ASER183
AHIS82
AARG168

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PDB entries from 2024-11-06

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