Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3H4P

Proteasome 20S core particle from Methanocaldococcus jannaschii

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000502	cellular_component	proteasome complex
a	0004175	molecular_function	endopeptidase activity
a	0004298	molecular_function	threonine-type endopeptidase activity
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0005839	cellular_component	proteasome core complex
a	0006508	biological_process	proteolysis
a	0008233	molecular_function	peptidase activity
a	0010498	biological_process	proteasomal protein catabolic process
a	0016787	molecular_function	hydrolase activity
a	0019774	cellular_component	proteasome core complex, beta-subunit complex
a	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
a	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
A	0000502	cellular_component	proteasome complex
A	0004175	molecular_function	endopeptidase activity
A	0004298	molecular_function	threonine-type endopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0010498	biological_process	proteasomal protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
b	0000502	cellular_component	proteasome complex
b	0004175	molecular_function	endopeptidase activity
b	0004298	molecular_function	threonine-type endopeptidase activity
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005839	cellular_component	proteasome core complex
b	0006508	biological_process	proteolysis
b	0008233	molecular_function	peptidase activity
b	0010498	biological_process	proteasomal protein catabolic process
b	0016787	molecular_function	hydrolase activity
b	0019774	cellular_component	proteasome core complex, beta-subunit complex
b	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
b	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0004175	molecular_function	endopeptidase activity
B	0004298	molecular_function	threonine-type endopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0010498	biological_process	proteasomal protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
c	0000502	cellular_component	proteasome complex
c	0004175	molecular_function	endopeptidase activity
c	0004298	molecular_function	threonine-type endopeptidase activity
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0005839	cellular_component	proteasome core complex
c	0006508	biological_process	proteolysis
c	0008233	molecular_function	peptidase activity
c	0010498	biological_process	proteasomal protein catabolic process
c	0016787	molecular_function	hydrolase activity
c	0019774	cellular_component	proteasome core complex, beta-subunit complex
c	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
c	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
C	0000502	cellular_component	proteasome complex
C	0004175	molecular_function	endopeptidase activity
C	0004298	molecular_function	threonine-type endopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0010498	biological_process	proteasomal protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
d	0000502	cellular_component	proteasome complex
d	0004175	molecular_function	endopeptidase activity
d	0004298	molecular_function	threonine-type endopeptidase activity
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0005839	cellular_component	proteasome core complex
d	0006508	biological_process	proteolysis
d	0008233	molecular_function	peptidase activity
d	0010498	biological_process	proteasomal protein catabolic process
d	0016787	molecular_function	hydrolase activity
d	0019774	cellular_component	proteasome core complex, beta-subunit complex
d	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
d	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
D	0000502	cellular_component	proteasome complex
D	0004175	molecular_function	endopeptidase activity
D	0004298	molecular_function	threonine-type endopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0010498	biological_process	proteasomal protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
e	0000502	cellular_component	proteasome complex
e	0004175	molecular_function	endopeptidase activity
e	0004298	molecular_function	threonine-type endopeptidase activity
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0005839	cellular_component	proteasome core complex
e	0006508	biological_process	proteolysis
e	0008233	molecular_function	peptidase activity
e	0010498	biological_process	proteasomal protein catabolic process
e	0016787	molecular_function	hydrolase activity
e	0019774	cellular_component	proteasome core complex, beta-subunit complex
e	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
e	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
E	0000502	cellular_component	proteasome complex
E	0004175	molecular_function	endopeptidase activity
E	0004298	molecular_function	threonine-type endopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0010498	biological_process	proteasomal protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
f	0000502	cellular_component	proteasome complex
f	0004175	molecular_function	endopeptidase activity
f	0004298	molecular_function	threonine-type endopeptidase activity
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0005839	cellular_component	proteasome core complex
f	0006508	biological_process	proteolysis
f	0008233	molecular_function	peptidase activity
f	0010498	biological_process	proteasomal protein catabolic process
f	0016787	molecular_function	hydrolase activity
f	0019774	cellular_component	proteasome core complex, beta-subunit complex
f	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
f	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0004175	molecular_function	endopeptidase activity
F	0004298	molecular_function	threonine-type endopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0010498	biological_process	proteasomal protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
g	0000502	cellular_component	proteasome complex
g	0004175	molecular_function	endopeptidase activity
g	0004298	molecular_function	threonine-type endopeptidase activity
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0005839	cellular_component	proteasome core complex
g	0006508	biological_process	proteolysis
g	0008233	molecular_function	peptidase activity
g	0010498	biological_process	proteasomal protein catabolic process
g	0016787	molecular_function	hydrolase activity
g	0019774	cellular_component	proteasome core complex, beta-subunit complex
g	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
g	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
G	0000502	cellular_component	proteasome complex
G	0004175	molecular_function	endopeptidase activity
G	0004298	molecular_function	threonine-type endopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0010498	biological_process	proteasomal protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
h	0000502	cellular_component	proteasome complex
h	0004175	molecular_function	endopeptidase activity
h	0004298	molecular_function	threonine-type endopeptidase activity
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0005839	cellular_component	proteasome core complex
h	0006508	biological_process	proteolysis
h	0008233	molecular_function	peptidase activity
h	0010498	biological_process	proteasomal protein catabolic process
h	0016787	molecular_function	hydrolase activity
h	0019774	cellular_component	proteasome core complex, beta-subunit complex
h	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
h	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
H	0000502	cellular_component	proteasome complex
H	0004175	molecular_function	endopeptidase activity
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0005839	cellular_component	proteasome core complex
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0010498	biological_process	proteasomal protein catabolic process
H	0019773	cellular_component	proteasome core complex, alpha-subunit complex
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
i	0000502	cellular_component	proteasome complex
i	0004175	molecular_function	endopeptidase activity
i	0004298	molecular_function	threonine-type endopeptidase activity
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0005839	cellular_component	proteasome core complex
i	0006508	biological_process	proteolysis
i	0008233	molecular_function	peptidase activity
i	0010498	biological_process	proteasomal protein catabolic process
i	0016787	molecular_function	hydrolase activity
i	0019774	cellular_component	proteasome core complex, beta-subunit complex
i	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
i	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0004175	molecular_function	endopeptidase activity
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0005839	cellular_component	proteasome core complex
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0010498	biological_process	proteasomal protein catabolic process
I	0019773	cellular_component	proteasome core complex, alpha-subunit complex
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
j	0000502	cellular_component	proteasome complex
j	0004175	molecular_function	endopeptidase activity
j	0004298	molecular_function	threonine-type endopeptidase activity
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0005839	cellular_component	proteasome core complex
j	0006508	biological_process	proteolysis
j	0008233	molecular_function	peptidase activity
j	0010498	biological_process	proteasomal protein catabolic process
j	0016787	molecular_function	hydrolase activity
j	0019774	cellular_component	proteasome core complex, beta-subunit complex
j	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
j	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
J	0000502	cellular_component	proteasome complex
J	0004175	molecular_function	endopeptidase activity
J	0004298	molecular_function	threonine-type endopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0005839	cellular_component	proteasome core complex
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0010498	biological_process	proteasomal protein catabolic process
J	0019773	cellular_component	proteasome core complex, alpha-subunit complex
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
k	0000502	cellular_component	proteasome complex
k	0004175	molecular_function	endopeptidase activity
k	0004298	molecular_function	threonine-type endopeptidase activity
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0005839	cellular_component	proteasome core complex
k	0006508	biological_process	proteolysis
k	0008233	molecular_function	peptidase activity
k	0010498	biological_process	proteasomal protein catabolic process
k	0016787	molecular_function	hydrolase activity
k	0019774	cellular_component	proteasome core complex, beta-subunit complex
k	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
k	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
K	0000502	cellular_component	proteasome complex
K	0004175	molecular_function	endopeptidase activity
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0005839	cellular_component	proteasome core complex
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0010498	biological_process	proteasomal protein catabolic process
K	0019773	cellular_component	proteasome core complex, alpha-subunit complex
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
l	0000502	cellular_component	proteasome complex
l	0004175	molecular_function	endopeptidase activity
l	0004298	molecular_function	threonine-type endopeptidase activity
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0005839	cellular_component	proteasome core complex
l	0006508	biological_process	proteolysis
l	0008233	molecular_function	peptidase activity
l	0010498	biological_process	proteasomal protein catabolic process
l	0016787	molecular_function	hydrolase activity
l	0019774	cellular_component	proteasome core complex, beta-subunit complex
l	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
l	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
L	0000502	cellular_component	proteasome complex
L	0004175	molecular_function	endopeptidase activity
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0005839	cellular_component	proteasome core complex
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0010498	biological_process	proteasomal protein catabolic process
L	0019773	cellular_component	proteasome core complex, alpha-subunit complex
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
m	0000502	cellular_component	proteasome complex
m	0004175	molecular_function	endopeptidase activity
m	0004298	molecular_function	threonine-type endopeptidase activity
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0005839	cellular_component	proteasome core complex
m	0006508	biological_process	proteolysis
m	0008233	molecular_function	peptidase activity
m	0010498	biological_process	proteasomal protein catabolic process
m	0016787	molecular_function	hydrolase activity
m	0019774	cellular_component	proteasome core complex, beta-subunit complex
m	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
m	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
M	0000502	cellular_component	proteasome complex
M	0004175	molecular_function	endopeptidase activity
M	0004298	molecular_function	threonine-type endopeptidase activity
M	0005737	cellular_component	cytoplasm
M	0005839	cellular_component	proteasome core complex
M	0006511	biological_process	ubiquitin-dependent protein catabolic process
M	0010498	biological_process	proteasomal protein catabolic process
M	0019773	cellular_component	proteasome core complex, alpha-subunit complex
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
n	0000502	cellular_component	proteasome complex
n	0004175	molecular_function	endopeptidase activity
n	0004298	molecular_function	threonine-type endopeptidase activity
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0005839	cellular_component	proteasome core complex
n	0006508	biological_process	proteolysis
n	0008233	molecular_function	peptidase activity
n	0010498	biological_process	proteasomal protein catabolic process
n	0016787	molecular_function	hydrolase activity
n	0019774	cellular_component	proteasome core complex, beta-subunit complex
n	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
n	0051603	biological_process	obsolete proteolysis involved in protein catabolic process
N	0000502	cellular_component	proteasome complex
N	0004175	molecular_function	endopeptidase activity
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005737	cellular_component	cytoplasm
N	0005839	cellular_component	proteasome core complex
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0010498	biological_process	proteasomal protein catabolic process
N	0019773	cellular_component	proteasome core complex, alpha-subunit complex
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0051603	biological_process	obsolete proteolysis involved in protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdraiTvFSPeGRlyQVEYAreA

Chain	Residue	Details
A	TYR9-ALA31

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGLiCddAVILATDkraslgnlvadkeak.KlykiddyiamtiaGsvGD

Chain	Residue	Details
m	VAL10-ASP57

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_02113","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
A	GLY81
A	LYS67
A	THR36
A	SER168

site_id	CSA10
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
J	GLY81
J	LYS67
J	THR36
J	SER168

site_id	CSA11
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
K	GLY81
K	LYS67
K	THR36
K	SER168

site_id	CSA12
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
L	GLY81
L	LYS67
L	THR36
L	SER168

site_id	CSA13
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
M	GLY81
M	LYS67
M	THR36
M	SER168

site_id	CSA14
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
N	GLY81
N	LYS67
N	THR36
N	SER168

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
B	GLY81
B	LYS67
B	THR36
B	SER168

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
C	GLY81
C	LYS67
C	THR36
C	SER168

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
D	GLY81
D	LYS67
D	THR36
D	SER168

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
E	GLY81
E	LYS67
E	THR36
E	SER168

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
F	GLY81
F	LYS67
F	THR36
F	SER168

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
G	GLY81
G	LYS67
G	THR36
G	SER168

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
H	GLY81
H	LYS67
H	THR36
H	SER168

site_id	CSA9
Number of Residues	4
Details	Annotated By Reference To The Literature 1pma

Chain	Residue	Details
I	GLY81
I	LYS67
I	THR36
I	SER168

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)