3H3U
Crystal structure of CRP (cAMP receptor Protein) from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0030552 | molecular_function | cAMP binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0030552 | molecular_function | cAMP binding |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 225 |
| Chain | Residue |
| A | GLY79 |
| A | LEU81 |
| A | SER82 |
| A | ARG89 |
| A | THR90 |
| A | SER91 |
| A | HOH230 |
| B | ARG132 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 225 |
| Chain | Residue |
| B | GLY79 |
| B | LEU81 |
| B | SER82 |
| B | ARG89 |
| B | THR90 |
| A | ARG132 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CMP B 226 |
| Chain | Residue |
| A | ALA114 |
| A | GLY166 |
| A | GLY167 |
| B | MET1 |
| B | ASP2 |
| B | ALA114 |
| B | ASP115 |
| B | PRO117 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 38 |
| Details | DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00387 |
| Chain | Residue | Details |
| A | GLN177-ALA196 | |
| B | GLN177-ALA196 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0ACJ8 |
| Chain | Residue | Details |
| A | GLY64 | |
| A | ILE142 | |
| A | GLU178 | |
| B | GLY64 | |
| B | ILE142 | |
| B | GLU178 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|Ref.9 |
| Chain | Residue | Details |
| A | GLY79 | |
| A | ARG89 | |
| A | THR134 | |
| B | GLY79 | |
| B | ARG89 | |
| B | THR134 |
