Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE RFZ A 336 |
| Chain | Residue |
| A | LEU45 |
| A | VAL53 |
| A | VAL116 |
| A | ASN118 |
| A | MET163 |
| A | ILE174 |
| A | HOH554 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE RFZ A 337 |
| Chain | Residue |
| A | ARG19 |
| A | ARG21 |
| A | GLN40 |
| A | LEU41 |
| A | ILE69 |
| A | VAL101 |
| A | ASP103 |
| A | PRO104 |
| A | ALA110 |
| A | HOH409 |
| A | HOH449 |
| A | HOH595 |
| A | THR17 |
| A | HIS18 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 338 |
| Chain | Residue |
| A | VAL11 |
| A | HIS148 |
| A | ALA315 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 339 |
| Chain | Residue |
| A | LYS68 |
| A | ASP175 |
| A | HOH429 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 340 |
| Chain | Residue |
| A | PRO159 |
| A | HIS160 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 341 |
| Chain | Residue |
| A | LYS77 |
| A | ARG80 |
| A | ARG155 |
| A | CL342 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 342 |
| Chain | Residue |
| A | ARG155 |
| A | GLU180 |
| A | CL341 |
| A | HOH553 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 343 |
| Chain | Residue |
| A | HOH401 |
| A | HOH565 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 344 |
| Chain | Residue |
| A | HIS29 |
| A | VAL31 |
| A | GLU32 |
| A | GLU86 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 345 |
| Chain | Residue |
| A | PHE232 |
| A | HIS234 |
| A | ARG244 |
| A | HOH513 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 346 |
| Chain | Residue |
| A | VAL293 |
| A | PRO295 |
| B | LYS198 |
| B | ASN238 |
| B | HOH479 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 347 |
| Chain | Residue |
| A | ASN238 |
| A | HOH446 |
| A | HOH575 |
| A | HOH578 |
| B | VAL293 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 348 |
| Chain | Residue |
| A | LYS303 |
| A | LEU313 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 349 |
| Chain | Residue |
| A | ARG306 |
| A | TYR307 |
| A | HOH592 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 350 |
| Chain | Residue |
| A | THR251 |
| A | TYR255 |
| A | ARG275 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 351 |
| Chain | Residue |
| A | ARG278 |
| A | LYS279 |
| A | ARG280 |
| A | ARG283 |
| site_id | BC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE RFZ B 336 |
| Chain | Residue |
| B | GLY46 |
| B | ARG47 |
| B | GLY48 |
| B | VAL53 |
| B | ILE95 |
| B | VAL116 |
| B | ASN117 |
| B | ASN118 |
| B | ILE174 |
| B | HOH473 |
| B | HOH575 |
| B | HOH640 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 337 |
| Chain | Residue |
| B | HIS148 |
| B | ALA315 |
| site_id | CC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 338 |
| Chain | Residue |
| B | ARG80 |
| B | ARG155 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 339 |
| Chain | Residue |
| B | ARG155 |
| B | TYR188 |
| B | ASN189 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 340 |
| Chain | Residue |
| B | LYS122 |
| B | PRO159 |
| B | HIS160 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 341 |
| Chain | Residue |
| B | LYS68 |
| B | ASP175 |
| B | HOH575 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 342 |
| Chain | Residue |
| A | ARG19 |
| A | HOH503 |
| B | LYS170 |
| B | HOH551 |
| site_id | CC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 343 |
| Chain | Residue |
| B | HOH449 |
| B | HOH415 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 344 |
| Chain | Residue |
| A | LYS170 |
| A | HOH544 |
| B | ARG19 |
| site_id | CC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL B 345 |
| Chain | Residue |
| B | LYS229 |
| B | PHE232 |
| B | HIS234 |
| B | ARG244 |
| B | HOH384 |
| B | HOH536 |
| site_id | CC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 346 |
| Chain | Residue |
| A | HOH643 |
| B | HIS321 |
| B | PRO322 |
| B | HOH556 |
| site_id | DC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 347 |
| Chain | Residue |
| B | ASP253 |
| B | ARG278 |
| B | HOH546 |
| site_id | DC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 348 |
| Chain | Residue |
| A | LYS329 |
| A | HOH658 |
| site_id | DC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 349 |
| Chain | Residue |
| B | HIS29 |
| B | VAL31 |
| B | GLU32 |
| B | GLU86 |
| site_id | DC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 350 |
| Chain | Residue |
| A | GLN40 |
| B | ARG333 |
| site_id | DC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 351 |
| Chain | Residue |
| B | ARG19 |
| B | PRO20 |
| B | HOH616 |
| B | HOH649 |
| site_id | DC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 352 |
| Chain | Residue |
| B | SER194 |
| B | ARG195 |
| B | HOH565 |
| site_id | DC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 353 |
| Chain | Residue |
| B | LYS303 |
| B | HIS321 |
| B | HOH366 |
| B | HOH456 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK |
| Chain | Residue | Details |
| A | LEU45-LYS68 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI |
| Chain | Residue | Details |
| A | ILE152-ILE164 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 570 |
| Details | Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Region: {"description":"Interaction with beta subunit","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP156 | |
| A | HIS160 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASP156 | |
| B | HIS160 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP156 | |
| A | LYS158 | |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASP156 | |
| B | LYS158 | |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP156 | |
| A | LYS158 | |
| A | SER194 | |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASP156 | |
| B | LYS158 | |
| B | SER194 | |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP156 | |
| A | ASN161 | |
| A | LYS158 | |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASP156 | |
| B | ASN161 | |
| B | LYS158 | |
