3H2N
Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004156 | molecular_function | dihydropteroate synthase activity |
A | 0005829 | cellular_component | cytosol |
A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0042558 | biological_process | pteridine-containing compound metabolic process |
A | 0044237 | biological_process | cellular metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046656 | biological_process | folic acid biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
B | 0004156 | molecular_function | dihydropteroate synthase activity |
B | 0005829 | cellular_component | cytosol |
B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
B | 0042558 | biological_process | pteridine-containing compound metabolic process |
B | 0044237 | biological_process | cellular metabolic process |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0046656 | biological_process | folic acid biosynthetic process |
B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE B62 A 901 |
Chain | Residue |
A | ASP101 |
A | ARG254 |
A | HOH287 |
A | SO4301 |
A | ASN120 |
A | ILE122 |
A | ILE143 |
A | ASP184 |
A | PHE189 |
A | LEU214 |
A | GLY216 |
A | LYS220 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 301 |
Chain | Residue |
A | ARG254 |
A | HIS256 |
A | HOH297 |
A | B62901 |
site_id | AC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 A 303 |
Chain | Residue |
A | LYS50 |
A | ARG53 |
site_id | AC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE SO4 A 305 |
Chain | Residue |
A | ARG219 |
site_id | AC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 A 306 |
Chain | Residue |
A | SER221 |
A | ARG234 |
site_id | AC6 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE B62 B 902 |
Chain | Residue |
B | ASP101 |
B | ASN120 |
B | ILE122 |
B | ASP184 |
B | PHE189 |
B | GLY216 |
B | LYS220 |
B | ARG254 |
B | HOH279 |
B | SO4302 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 302 |
Chain | Residue |
B | ILE25 |
B | ARG254 |
B | HIS256 |
B | HOH309 |
B | B62902 |
site_id | AC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 B 304 |
Chain | Residue |
B | LYS50 |
B | ARG53 |
site_id | AC9 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE SO4 B 307 |
Chain | Residue |
B | ARG219 |
site_id | BC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 308 |
Chain | Residue |
B | SER221 |
B | ARG234 |
B | HOH285 |
Functional Information from PROSITE/UniProt
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1aj0 |
Chain | Residue | Details |
A | ARG254 | |
A | ARG68 | |
A | ASN27 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1aj0 |
Chain | Residue | Details |
B | ARG254 | |
B | ASN27 |