3H03

Crystal structure of the binding domain of the AMPA subunit GluR2 bound to UBP277

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
G	0015276	molecular_function	ligand-gated monoatomic ion channel activity
G	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE UBP A 801

Chain	Residue
A	TYR61
A	MET196
A	TYR220
A	HOH313
A	HOH351
A	HOH561
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	THR174
A	TYR190
A	LEU192
A	GLU193

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	GLU42
A	HIS46

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A 262

Chain	Residue
A	HIS23
B	HOH673

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE UBP B 802

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	THR174
B	TYR190
B	LEU192
B	GLU193
B	MET196
B	TYR220
B	HOH329
B	HOH344
B	HOH680

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN B 3

Chain	Residue
B	GLU42
B	HIS46

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 262

Chain	Residue
A	ASP139
B	HIS23
B	GLU24

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE UBP D 803

Chain	Residue
D	TYR61
D	PRO89
D	LEU90
D	THR91
D	ARG96
D	THR174
D	TYR190
D	LEU192
D	GLU193
D	MET196
D	TYR220
D	HOH289
D	HOH303
D	HOH344

---

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN D 2

Chain	Residue
D	HIS23

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN D 262

Chain	Residue
D	GLU42
D	HIS46

---

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE UBP G 804

Chain	Residue
G	TYR61
G	PRO89
G	LEU90
G	THR91
G	ARG96
G	THR174
G	TYR190
G	LEU192
G	GLU193
G	MET196
G	TYR220
G	HOH313
G	HOH325
G	HOH776

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN G 262

Chain	Residue
G	GLU42
G	HIS46

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN G 263

Chain	Residue
D	ASP139
G	HIS23
G	GLU24

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
B	SER142
B	THR143
B	GLU193
D	PRO89
D	THR91
D	ARG96
D	SER142
D	THR143
D	GLU193
G	PRO89
A	THR91
G	THR91
G	ARG96
G	SER142
G	THR143
G	GLU193
A	ARG96
A	SER142
A	THR143
A	GLU193
B	PRO89
B	THR91
B	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
G	ARG64
G	ARG148
G	LYS240
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240
D	ARG64
D	ARG148
D	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121
D	ILE121
G	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150
D	SER150
G	SER150

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184
D	SER184
G	SER184

---