3H03

Crystal structure of the binding domain of the AMPA subunit GluR2 bound to UBP277

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
G	0015276	molecular_function	ligand-gated monoatomic ion channel activity
G	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE UBP A 801

Chain	Residue
A	TYR61
A	MET196
A	TYR220
A	HOH313
A	HOH351
A	HOH561
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	THR174
A	TYR190
A	LEU192
A	GLU193

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	GLU42
A	HIS46

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A 262

Chain	Residue
A	HIS23
B	HOH673

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE UBP B 802

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	THR174
B	TYR190
B	LEU192
B	GLU193
B	MET196
B	TYR220
B	HOH329
B	HOH344
B	HOH680

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN B 3

Chain	Residue
B	GLU42
B	HIS46

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 262

Chain	Residue
A	ASP139
B	HIS23
B	GLU24

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE UBP D 803

Chain	Residue
D	TYR61
D	PRO89
D	LEU90
D	THR91
D	ARG96
D	THR174
D	TYR190
D	LEU192
D	GLU193
D	MET196
D	TYR220
D	HOH289
D	HOH303
D	HOH344

---

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN D 2

Chain	Residue
D	HIS23

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN D 262

Chain	Residue
D	GLU42
D	HIS46

---

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE UBP G 804

Chain	Residue
G	TYR61
G	PRO89
G	LEU90
G	THR91
G	ARG96
G	THR174
G	TYR190
G	LEU192
G	GLU193
G	MET196
G	TYR220
G	HOH313
G	HOH325
G	HOH776

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN G 262

Chain	Residue
G	GLU42
G	HIS46

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN G 263

Chain	Residue
D	ASP139
G	HIS23
G	GLU24

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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