3H02
2.15 Angstrom Resolution Crystal Structure of Naphthoate Synthase from Salmonella typhimurium.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| A | 0009234 | biological_process | menaquinone biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| B | 0009234 | biological_process | menaquinone biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| C | 0009234 | biological_process | menaquinone biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| D | 0009234 | biological_process | menaquinone biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| E | 0009234 | biological_process | menaquinone biosynthetic process |
| E | 0016829 | molecular_function | lyase activity |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0008935 | molecular_function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity |
| F | 0009234 | biological_process | menaquinone biosynthetic process |
| F | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 286 |
| Chain | Residue |
| A | ILE174 |
| A | HOH589 |
| B | ILE174 |
| C | ILE174 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BCT A 287 |
| Chain | Residue |
| A | PHE162 |
| A | TRP184 |
| A | GLY132 |
| A | GLY133 |
| A | GLN154 |
| A | THR155 |
| A | GLY156 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BCT B 286 |
| Chain | Residue |
| B | GLY132 |
| B | GLY133 |
| B | GLN154 |
| B | THR155 |
| B | GLY156 |
| B | PHE162 |
| B | ASP163 |
| B | TRP184 |
| B | HOH556 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BCT C 286 |
| Chain | Residue |
| C | GLY132 |
| C | GLY133 |
| C | GLN154 |
| C | THR155 |
| C | GLY156 |
| C | PHE162 |
| C | TRP184 |
| C | HOH501 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BCT D 286 |
| Chain | Residue |
| D | GLY132 |
| D | GLY133 |
| D | GLN154 |
| D | THR155 |
| D | GLY156 |
| D | PHE162 |
| D | TRP184 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BCT E 286 |
| Chain | Residue |
| E | GLY132 |
| E | GLY133 |
| E | GLN154 |
| E | THR155 |
| E | GLY156 |
| E | PHE162 |
| E | TRP184 |
| E | HOH591 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 F 286 |
| Chain | Residue |
| D | ILE174 |
| D | VAL175 |
| D | GLY176 |
| E | ILE174 |
| E | VAL175 |
| E | GLY176 |
| F | ILE174 |
| F | VAL175 |
| F | GLY176 |
| F | HOH510 |
| F | HOH583 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BCT F 287 |
| Chain | Residue |
| F | GLY132 |
| F | GLY133 |
| F | GLN154 |
| F | THR155 |
| F | GLY156 |
| F | PHE162 |
| F | TRP184 |
| F | HOH630 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BCT F 288 |
| Chain | Residue |
| F | GLU20 |
| F | TYR22 |
| F | GLN58 |
| F | HOH483 |
| F | HOH614 |
Functional Information from PROSITE/UniProt
| site_id | PS00166 |
| Number of Residues | 21 |
| Details | ENOYL_COA_HYDRATASE Enoyl-CoA hydratase/isomerase signature. VAmVAGysiGGGhvlhMmCDL |
| Chain | Residue | Details |
| A | VAL123-LEU143 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 30 |
| Details | BINDING: in other chain => ECO:0000250|UniProtKB:P0ABU0, ECO:0000255|HAMAP-Rule:MF_01934 |
| Chain | Residue | Details |
| A | ARG45 | |
| B | SER161 | |
| C | ARG45 | |
| C | TYR97 | |
| C | TYR129 | |
| C | THR155 | |
| C | SER161 | |
| D | ARG45 | |
| D | TYR97 | |
| D | TYR129 | |
| D | THR155 | |
| A | TYR97 | |
| D | SER161 | |
| E | ARG45 | |
| E | TYR97 | |
| E | TYR129 | |
| E | THR155 | |
| E | SER161 | |
| F | ARG45 | |
| F | TYR97 | |
| F | TYR129 | |
| F | THR155 | |
| A | TYR129 | |
| F | SER161 | |
| A | THR155 | |
| A | SER161 | |
| B | ARG45 | |
| B | TYR97 | |
| B | TYR129 | |
| B | THR155 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_01934 |
| Chain | Residue | Details |
| A | ALA84 | |
| B | ALA84 | |
| C | ALA84 | |
| D | ALA84 | |
| E | ALA84 | |
| F | ALA84 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01934, ECO:0000269|Ref.2 |
| Chain | Residue | Details |
| A | GLN154 | |
| B | GLN154 | |
| C | GLN154 | |
| D | GLN154 | |
| E | GLN154 | |
| F | GLN154 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0ABU0, ECO:0000255|HAMAP-Rule:MF_01934 |
| Chain | Residue | Details |
| A | TYR258 | |
| E | LYS273 | |
| F | TYR258 | |
| F | LYS273 | |
| A | LYS273 | |
| B | TYR258 | |
| B | LYS273 | |
| C | TYR258 | |
| C | LYS273 | |
| D | TYR258 | |
| D | LYS273 | |
| E | TYR258 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | SITE: Important for catalysis => ECO:0000250|UniProtKB:P0ABU0, ECO:0000255|HAMAP-Rule:MF_01934 |
| Chain | Residue | Details |
| A | TYR97 | |
| E | TYR258 | |
| F | TYR97 | |
| F | TYR258 | |
| A | TYR258 | |
| B | TYR97 | |
| B | TYR258 | |
| C | TYR97 | |
| C | TYR258 | |
| D | TYR97 | |
| D | TYR258 | |
| E | TYR97 |
