3GVI
Crystal structure of Lactate/malate dehydrogenase from Brucella melitensis in complex with ADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| C | 0006089 | biological_process | lactate metabolic process |
| C | 0006099 | biological_process | tricarboxylic acid cycle |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| D | 0006089 | biological_process | lactate metabolic process |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| E | 0006089 | biological_process | lactate metabolic process |
| E | 0006099 | biological_process | tricarboxylic acid cycle |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| E | 0019752 | biological_process | carboxylic acid metabolic process |
| E | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| F | 0006089 | biological_process | lactate metabolic process |
| F | 0006099 | biological_process | tricarboxylic acid cycle |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| F | 0019752 | biological_process | carboxylic acid metabolic process |
| F | 0030060 | molecular_function | L-malate dehydrogenase (NAD+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP A 401 |
| Chain | Residue |
| A | GLY12 |
| A | HOH354 |
| A | HOH359 |
| A | HOH391 |
| A | HOH448 |
| A | HOH528 |
| A | HOH831 |
| A | HOH1210 |
| A | MET13 |
| A | ILE14 |
| A | ASP34 |
| A | ILE35 |
| A | ALA79 |
| A | GLY80 |
| A | GLN102 |
| A | HOH340 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ADP B 401 |
| Chain | Residue |
| B | GLY12 |
| B | MET13 |
| B | ILE14 |
| B | PHE33 |
| B | ASP34 |
| B | ILE35 |
| B | ALA79 |
| B | GLY80 |
| B | GLN102 |
| B | HOH338 |
| B | HOH372 |
| B | HOH378 |
| B | HOH385 |
| B | HOH390 |
| B | HOH990 |
| B | HOH1076 |
| B | HOH1236 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP C 401 |
| Chain | Residue |
| C | GLY12 |
| C | MET13 |
| C | ILE14 |
| C | PHE33 |
| C | ASP34 |
| C | ILE35 |
| C | ALA79 |
| C | GLY80 |
| C | GLN102 |
| C | HOH323 |
| C | HOH350 |
| C | HOH360 |
| C | HOH366 |
| C | HOH727 |
| C | HOH1258 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP D 401 |
| Chain | Residue |
| D | GLY12 |
| D | MET13 |
| D | ILE14 |
| D | ASP34 |
| D | ILE35 |
| D | ALA79 |
| D | GLY80 |
| D | VAL99 |
| D | GLN102 |
| D | HOH332 |
| D | HOH336 |
| D | HOH338 |
| D | HOH586 |
| D | HOH635 |
| D | HOH841 |
| D | HOH1102 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ADP E 401 |
| Chain | Residue |
| E | GLY12 |
| E | MET13 |
| E | ILE14 |
| E | PHE33 |
| E | ASP34 |
| E | ILE35 |
| E | ALA79 |
| E | GLY80 |
| E | VAL99 |
| E | GLN102 |
| E | HOH341 |
| E | HOH445 |
| E | HOH523 |
| E | HOH600 |
| E | HOH670 |
| E | HOH1108 |
| E | HOH1298 |
| E | HOH1299 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ADP F 401 |
| Chain | Residue |
| F | GLY12 |
| F | MET13 |
| F | ILE14 |
| F | ASP34 |
| F | ILE35 |
| F | ALA79 |
| F | GLY80 |
| F | VAL99 |
| F | GLN102 |
| F | HOH324 |
| F | HOH345 |
| F | HOH363 |
| F | HOH414 |
| F | HOH645 |
| F | HOH730 |
| F | HOH959 |
| F | HOH1031 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00487","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 72 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00487","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| A | ASP149 | |
| A | HIS176 |
| site_id | CSA10 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| D | ARG152 | |
| D | ASP149 | |
| D | HIS176 |
| site_id | CSA11 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| E | ARG152 | |
| E | ASP149 | |
| E | HIS176 |
| site_id | CSA12 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| F | ARG152 | |
| F | ASP149 | |
| F | HIS176 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| B | ASP149 | |
| B | HIS176 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| C | ASP149 | |
| C | HIS176 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| D | ASP149 | |
| D | HIS176 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| E | ASP149 | |
| E | HIS176 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| F | ASP149 | |
| F | HIS176 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| A | ARG152 | |
| A | ASP149 | |
| A | HIS176 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| B | ARG152 | |
| B | ASP149 | |
| B | HIS176 |
| site_id | CSA9 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| C | ARG152 | |
| C | ASP149 | |
| C | HIS176 |
