3GUC

Human Ubiquitin-activating Enzyme 5 in Complex with AMPPNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008641	molecular_function	ubiquitin-like modifier activating enzyme activity
B	0008641	molecular_function	ubiquitin-like modifier activating enzyme activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	CYS226
A	CYS229
A	CYS303
A	CYS308

---

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ANP A 402

Chain	Residue
A	TYR105
A	ASP106
A	LYS127
A	ASN150
A	ILE151
A	THR152
A	CYS181
A	VAL182
A	ASP183
A	ASN184
A	ALA187
A	VAL207
A	HOH427
A	HOH463
A	GLY80
A	GLY82
A	GLY83
A	VAL84
A	ASP104

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 401

Chain	Residue
B	CYS226
B	CYS229
B	CYS303
B	CYS308

---

Functional Information from PROSITE/UniProt

site_id	PS00065
Number of Residues	29
Details	D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. VAIVGvGGVGsvtaemltrcgigkLLlFD

Chain	Residue	Details
A	VAL76-ASP104

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PubMed","id":"20368332","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27545674","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27653677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34588452","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20368332","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27653677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30412706","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6H77","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6H78","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20368332","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27653677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30412706","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5L95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6H78","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20368332","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27653677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30412706","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IAA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6H77","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6H78","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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