3GRI

The Crystal Structure of a Dihydroorotase from Staphylococcus aureus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004038	molecular_function	allantoinase activity
A	0004151	molecular_function	dihydroorotase activity
A	0005737	cellular_component	cytoplasm
A	0006145	biological_process	purine nucleobase catabolic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0004038	molecular_function	allantoinase activity
B	0004151	molecular_function	dihydroorotase activity
B	0005737	cellular_component	cytoplasm
B	0006145	biological_process	purine nucleobase catabolic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity
B	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
B	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 500

Chain	Residue
A	HIS58
A	HIS60
A	ASP303
A	HOH491
A	HOH658

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 600

Chain	Residue
A	ILE124
A	THR125
A	HOH482

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 601

Chain	Residue
A	THR86
A	TYR364
A	ASP374
A	HOH458
A	THR85

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 700

Chain	Residue
A	PHE391
A	SER393
A	HOH490
A	HOH527
A	HOH610
A	HOH628

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 701

Chain	Residue
A	GLU104
A	GLU142
A	GLY199
A	HOH433
A	HOH517

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 500

Chain	Residue
B	HIS58
B	HIS60
B	ASP303
B	HOH492

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 600

Chain	Residue
B	ILE124
B	THR125
B	HOH551

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 700

Chain	Residue
B	PHE391
B	SER393
B	HOH540
B	HOH665

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 701

Chain	Residue
B	GLU104
B	GLU142
B	GLY199
B	HOH479
B	HOH493

---

Functional Information from PROSITE/UniProt

site_id	PS00482
Number of Residues	9
Details	DIHYDROOROTASE_1 Dihydroorotase signature 1. DVHVHLReP

Chain	Residue	Details
A	ASP56-PRO64

---

site_id	PS00483
Number of Residues	12
Details	DIHYDROOROTASE_2 Dihydroorotase signature 2. ATDhAPHardeK

Chain	Residue	Details
A	ALA301-LYS312

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00220

Chain	Residue	Details
A	ASP303
B	ASP303

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00220

Chain	Residue	Details
A	HIS58
A	PHE321
B	HIS58
B	HIS60
B	ASN92
B	ASP150
B	HIS177
B	HIS230
B	ASN276
B	ASP303
B	HIS307
A	HIS60
B	PHE321
A	ASN92
A	ASP150
A	HIS177
A	HIS230
A	ASN276
A	ASP303
A	HIS307

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