3GPE

Crystal Structure Analysis of PKC (alpha)-C2 domain complexed with Ca2+ and PtdIns(4,5)P2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 501

Chain	Residue
A	MET186
A	ASP187
A	ASP246
A	ASP248
A	ASP254
A	HOH304

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 502

Chain	Residue
A	TRP247
A	ASP248
A	PO4401
A	ASP187
A	ASP193
A	ASP246

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 503

Chain	Residue
A	ASP248
A	THR251
A	ARG252
A	ASP254

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 A 401

Chain	Residue
A	ASP187
A	ASP193
A	GLU207
A	ARG216
A	TRP247
A	ASP248
A	ARG249
A	HOH335
A	CA502

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PT5 A 600

Chain	Residue
A	HOH40
A	LYS172
A	LYS181
A	TYR195
A	LYS197
A	ASN206
A	LYS209
A	LYS211
A	ASN253
A	HOH316

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	117
Details	Domain: {"description":"C2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00041","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10562545","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10562545","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19346474","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19346474","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---