3GP3

Crystal structure of phosphoglyceromutase from Burkholderia pseudomallei with 2-phosphoserine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004619	molecular_function	phosphoglycerate mutase activity
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016853	molecular_function	isomerase activity
A	0016868	molecular_function	intramolecular phosphotransferase activity
B	0003824	molecular_function	catalytic activity
B	0004619	molecular_function	phosphoglycerate mutase activity
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0016853	molecular_function	isomerase activity
B	0016868	molecular_function	intramolecular phosphotransferase activity
C	0003824	molecular_function	catalytic activity
C	0004619	molecular_function	phosphoglycerate mutase activity
C	0006094	biological_process	gluconeogenesis
C	0006096	biological_process	glycolytic process
C	0016853	molecular_function	isomerase activity
C	0016868	molecular_function	intramolecular phosphotransferase activity
D	0003824	molecular_function	catalytic activity
D	0004619	molecular_function	phosphoglycerate mutase activity
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0016853	molecular_function	isomerase activity
D	0016868	molecular_function	intramolecular phosphotransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PG4 A 250

Chain	Residue
A	ASP51
A	ALA173
A	LYS175

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO3 A 251

Chain	Residue
A	GLY183
A	SEP252
A	HOH274
A	ARG8
A	HIS9
A	ASN15
A	ARG60
A	GLU87
A	HIS182

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SEP A 252

Chain	Residue
A	ARG8
A	ASN15
A	ARG19
A	THR21
A	GLY22
A	GLU87
A	ARG88
A	TYR90
A	LYS98
A	ARG114
A	ARG115
A	ASN184
A	PO3251
A	HOH278

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PG4 B 250

Chain	Residue
B	ASP51
B	ALA173
B	LYS175

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO3 B 251

Chain	Residue
B	ARG8
B	HIS9
B	ASN15
B	ARG60
B	GLU87
B	HIS182
B	GLY183
B	SEP252
B	HOH279

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SEP B 252

Chain	Residue
B	ARG8
B	ASN15
B	ARG19
B	THR21
B	GLY22
B	GLU87
B	TYR90
B	LYS98
B	ARG114
B	ARG115
B	ASN184
B	PO3251
B	HOH299

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 C 250

Chain	Residue
C	ASP51
C	ALA173
C	LYS175
C	HOH552

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PG4 C 251

Chain	Residue
C	ILE196
C	LEU204
C	HIS225
C	HOH332
C	HOH556

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO3 C 252

Chain	Residue
C	ARG8
C	HIS9
C	ASN15
C	ARG60
C	GLU87
C	HIS182
C	GLY183
C	SEP253

---

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SEP C 253

Chain	Residue
C	ARG8
C	ASN15
C	ARG19
C	PHE20
C	THR21
C	GLY22
C	GLU87
C	TYR90
C	LYS98
C	ARG114
C	ARG115
C	ASN184
C	PO3252
C	HOH305

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 D 250

Chain	Residue
D	ASP51
D	ALA173
D	LYS175
D	HOH601

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PG4 D 251

Chain	Residue
D	ILE190
D	ILE196
D	TYR214
D	HIS225
D	TYR227
D	HOH282
D	HOH374
D	HOH706

---

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO3 D 252

Chain	Residue
D	HIS182
D	GLY183
D	SEP253
D	HOH290
D	ARG8
D	HIS9
D	ASN15
D	ARG60
D	GLU87

---

site_id	BC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SEP D 253

Chain	Residue
D	ARG8
D	ASN15
D	ARG19
D	PHE20
D	THR21
D	GLY22
D	GLU87
D	TYR90
D	LYS98
D	ARG114
D	ARG115
D	ASN184
D	PO3252
D	HOH295

---

Functional Information from PROSITE/UniProt

site_id	PS00175
Number of Residues	10
Details	PG_MUTASE Phosphoglycerate mutase family phosphohistidine signature. LiRHGEsTwN

Chain	Residue	Details
A	LEU6-ASN15

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Tele-phosphohistidine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01039","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_01039","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21904048","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3FDZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01039","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"HAMAP-Rule","id":"MF_01039","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
A	HIS182
A	ARG60
A	GLU87
A	HIS9

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
B	HIS182
B	ARG60
B	GLU87
B	HIS9

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
C	HIS182
C	ARG60
C	GLU87
C	HIS9

---

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1qhf

Chain	Residue	Details
D	HIS182
D	ARG60
D	GLU87
D	HIS9

---