3GOA
Crystal structure of the Salmonella typhimurium FadA 3-ketoacyl-CoA thiolase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003988 | molecular_function | acetyl-CoA C-acyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006635 | biological_process | fatty acid beta-oxidation |
| A | 0010124 | biological_process | phenylacetate catabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0044281 | biological_process | small molecule metabolic process |
| B | 0003988 | molecular_function | acetyl-CoA C-acyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006635 | biological_process | fatty acid beta-oxidation |
| B | 0010124 | biological_process | phenylacetate catabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0044281 | biological_process | small molecule metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 388 |
| Chain | Residue |
| B | HOH419 |
| B | HOH694 |
| B | HOH756 |
| B | HOH773 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 389 |
| Chain | Residue |
| B | HOH512 |
| B | HOH601 |
| B | HOH835 |
| B | HOH935 |
| B | HOH936 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 388 |
| Chain | Residue |
| A | ALA9 |
| A | ARG41 |
| A | THR187 |
| A | GLU188 |
| A | ARG264 |
| A | ASN358 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 389 |
| Chain | Residue |
| A | ALA265 |
| A | ARG266 |
| A | VAL387 |
| A | HOH934 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA B 390 |
| Chain | Residue |
| B | ARG266 |
| B | GLU385 |
| B | HOH939 |
Functional Information from PROSITE/UniProt
| site_id | PS00098 |
| Number of Residues | 19 |
| Details | THIOLASE_1 Thiolases acyl-enzyme intermediate signature. VNRlCGSSMqALhdaarmI |
| Chain | Residue | Details |
| A | VAL87-ILE105 |
| site_id | PS00099 |
| Number of Residues | 14 |
| Details | THIOLASE_3 Thiolases active site. GLATMCIGlGqGiA |
| Chain | Residue | Details |
| A | GLY368-ALA381 |
| site_id | PS00178 |
| Number of Residues | 11 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. Pv.SGtVTAGTS |
| Chain | Residue | Details |
| A | PRO228-SER238 |
| site_id | PS00737 |
| Number of Residues | 17 |
| Details | THIOLASE_2 Thiolases signature 2. NlnGGaIAlGHPlGcSG |
| Chain | Residue | Details |
| A | ASN333-GLY349 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Acyl-thioester intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01620","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1afw |
| Chain | Residue | Details |
| A | GLY375 | |
| A | HIS343 | |
| A | CYS91 | |
| A | CYS373 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1afw |
| Chain | Residue | Details |
| B | GLY375 | |
| B | HIS343 | |
| B | CYS91 | |
| B | CYS373 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1afw |
| Chain | Residue | Details |
| A | HIS343 | |
| A | CYS373 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1afw |
| Chain | Residue | Details |
| B | HIS343 | |
| B | CYS373 |
