3GN4

Myosin lever arm

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000226	biological_process	microtubule cytoskeleton organization
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005814	cellular_component	centriole
B	0005819	cellular_component	spindle
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005938	cellular_component	cell cortex
B	0007099	biological_process	centriole replication
B	0007605	biological_process	sensory perception of sound
B	0007608	biological_process	sensory perception of smell
B	0016028	cellular_component	rhabdomere
B	0016056	biological_process	G protein-coupled opsin signaling pathway
B	0016059	biological_process	negative regulation of opsin-mediated signaling pathway
B	0016060	biological_process	negative regulation of phospholipase C-activating phototransduction signaling pathway
B	0016247	molecular_function	channel regulator activity
B	0030048	biological_process	actin filament-based movement
B	0030234	molecular_function	enzyme regulator activity
B	0030496	cellular_component	midbody
B	0031475	cellular_component	myosin V complex
B	0031476	cellular_component	myosin VI complex
B	0031477	cellular_component	myosin VII complex
B	0031489	molecular_function	myosin V binding
B	0032036	molecular_function	myosin heavy chain binding
B	0042052	biological_process	rhabdomere development
B	0046716	biological_process	muscle cell cellular homeostasis
B	0046872	molecular_function	metal ion binding
B	0048102	biological_process	autophagic cell death
B	0050911	biological_process	detection of chemical stimulus involved in sensory perception of smell
B	0051383	biological_process	kinetochore organization
B	0070855	molecular_function	myosin VI head/neck binding
B	0071361	biological_process	cellular response to ethanol
B	0072499	biological_process	photoreceptor cell axon guidance
B	0072686	cellular_component	mitotic spindle
B	0097431	cellular_component	mitotic spindle pole
D	0000226	biological_process	microtubule cytoskeleton organization
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005814	cellular_component	centriole
D	0005819	cellular_component	spindle
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005938	cellular_component	cell cortex
D	0007099	biological_process	centriole replication
D	0007605	biological_process	sensory perception of sound
D	0007608	biological_process	sensory perception of smell
D	0016028	cellular_component	rhabdomere
D	0016056	biological_process	G protein-coupled opsin signaling pathway
D	0016059	biological_process	negative regulation of opsin-mediated signaling pathway
D	0016060	biological_process	negative regulation of phospholipase C-activating phototransduction signaling pathway
D	0016247	molecular_function	channel regulator activity
D	0030048	biological_process	actin filament-based movement
D	0030234	molecular_function	enzyme regulator activity
D	0030496	cellular_component	midbody
D	0031475	cellular_component	myosin V complex
D	0031476	cellular_component	myosin VI complex
D	0031477	cellular_component	myosin VII complex
D	0031489	molecular_function	myosin V binding
D	0032036	molecular_function	myosin heavy chain binding
D	0042052	biological_process	rhabdomere development
D	0046716	biological_process	muscle cell cellular homeostasis
D	0046872	molecular_function	metal ion binding
D	0048102	biological_process	autophagic cell death
D	0050911	biological_process	detection of chemical stimulus involved in sensory perception of smell
D	0051383	biological_process	kinetochore organization
D	0070855	molecular_function	myosin VI head/neck binding
D	0071361	biological_process	cellular response to ethanol
D	0072499	biological_process	photoreceptor cell axon guidance
D	0072686	cellular_component	mitotic spindle
D	0097431	cellular_component	mitotic spindle pole
F	0000226	biological_process	microtubule cytoskeleton organization
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005814	cellular_component	centriole
F	0005819	cellular_component	spindle
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005938	cellular_component	cell cortex
F	0007099	biological_process	centriole replication
F	0007605	biological_process	sensory perception of sound
F	0007608	biological_process	sensory perception of smell
F	0016028	cellular_component	rhabdomere
F	0016056	biological_process	G protein-coupled opsin signaling pathway
F	0016059	biological_process	negative regulation of opsin-mediated signaling pathway
F	0016060	biological_process	negative regulation of phospholipase C-activating phototransduction signaling pathway
F	0016247	molecular_function	channel regulator activity
F	0030048	biological_process	actin filament-based movement
F	0030234	molecular_function	enzyme regulator activity
F	0030496	cellular_component	midbody
F	0031475	cellular_component	myosin V complex
F	0031476	cellular_component	myosin VI complex
F	0031477	cellular_component	myosin VII complex
F	0031489	molecular_function	myosin V binding
F	0032036	molecular_function	myosin heavy chain binding
F	0042052	biological_process	rhabdomere development
F	0046716	biological_process	muscle cell cellular homeostasis
F	0046872	molecular_function	metal ion binding
F	0048102	biological_process	autophagic cell death
F	0050911	biological_process	detection of chemical stimulus involved in sensory perception of smell
F	0051383	biological_process	kinetochore organization
F	0070855	molecular_function	myosin VI head/neck binding
F	0071361	biological_process	cellular response to ethanol
F	0072499	biological_process	photoreceptor cell axon guidance
F	0072686	cellular_component	mitotic spindle
F	0097431	cellular_component	mitotic spindle pole
H	0000226	biological_process	microtubule cytoskeleton organization
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005814	cellular_component	centriole
H	0005819	cellular_component	spindle
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005938	cellular_component	cell cortex
H	0007099	biological_process	centriole replication
H	0007605	biological_process	sensory perception of sound
H	0007608	biological_process	sensory perception of smell
H	0016028	cellular_component	rhabdomere
H	0016056	biological_process	G protein-coupled opsin signaling pathway
H	0016059	biological_process	negative regulation of opsin-mediated signaling pathway
H	0016060	biological_process	negative regulation of phospholipase C-activating phototransduction signaling pathway
H	0016247	molecular_function	channel regulator activity
H	0030048	biological_process	actin filament-based movement
H	0030234	molecular_function	enzyme regulator activity
H	0030496	cellular_component	midbody
H	0031475	cellular_component	myosin V complex
H	0031476	cellular_component	myosin VI complex
H	0031477	cellular_component	myosin VII complex
H	0031489	molecular_function	myosin V binding
H	0032036	molecular_function	myosin heavy chain binding
H	0042052	biological_process	rhabdomere development
H	0046716	biological_process	muscle cell cellular homeostasis
H	0046872	molecular_function	metal ion binding
H	0048102	biological_process	autophagic cell death
H	0050911	biological_process	detection of chemical stimulus involved in sensory perception of smell
H	0051383	biological_process	kinetochore organization
H	0070855	molecular_function	myosin VI head/neck binding
H	0071361	biological_process	cellular response to ethanol
H	0072499	biological_process	photoreceptor cell axon guidance
H	0072686	cellular_component	mitotic spindle
H	0097431	cellular_component	mitotic spindle pole

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 201

Chain	Residue
B	ASP20
B	ASP22
B	ASP24
B	THR26
B	GLU31

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 202

Chain	Residue
B	GLU67
B	ASP56
B	ASP58
B	ASN60
B	THR62

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 203

Chain	Residue
B	ASP93
B	ASP95
B	ASN97
B	PHE99
B	GLU104

---

site_id	AC4
Number of Residues	5
Details

Chain	Residue
B	ASP129
B	ASP131
B	ASP133
B	GLN135
B	GLU140

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 201

Chain	Residue
D	ASP20
D	ASP22
D	ASP24
D	THR26

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG D 202

Chain	Residue
D	THR62

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 203

Chain	Residue
D	ASP93
D	ASP95
D	ASN97
D	PHE99

---

site_id	AC8
Number of Residues	4
Details

Chain	Residue
D	ASP129
D	ASP131
D	ASP133
D	GLN135

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 201

Chain	Residue
F	ASP20
F	ASP22
F	ASP24
F	THR26
F	GLU31

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 202

Chain	Residue
F	ASP56
F	ASP58
F	ASN60
F	THR62
F	GLU67

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 203

Chain	Residue
F	ASP93
F	ASP95
F	ASN97
F	PHE99
F	GLU104

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 204

Chain	Residue
F	ASP129
F	ASP131
F	ASP133
F	GLN135
F	ASN137
F	GLU140

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG H 201

Chain	Residue
H	ASP20
H	ASP22
H	ASP24
H	THR26

---

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG H 202

Chain	Residue
H	THR62

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG H 203

Chain	Residue
H	ASP93
H	ASP95
H	ASN97
H	PHE99

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG H 204

Chain	Residue
H	ASP129
H	ASP131
H	ASP133
H	GLN135

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
B	ASP20-LEU32
B	ASP56-PHE68
B	ASP93-LEU105
B	ASP129-PHE141

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	58
Details	Domain: {"description":"IQ","evidences":[{"source":"PubMed","id":"15037754","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	56
Details	Region: {"description":"Required for binding calmodulin","evidences":[{"source":"PubMed","id":"15037754","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	140
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	140
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	140
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	76
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Site: {"description":"Not N6-methylated"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"source":"PubMed","id":"17610210","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---