3GLS

Crystal Structure of Human SIRT3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0017136	molecular_function	histone deacetylase activity, NAD-dependent
A	0051287	molecular_function	NAD binding
A	0070403	molecular_function	NAD+ binding
B	0017136	molecular_function	histone deacetylase activity, NAD-dependent
B	0051287	molecular_function	NAD binding
B	0070403	molecular_function	NAD+ binding
C	0017136	molecular_function	histone deacetylase activity, NAD-dependent
C	0051287	molecular_function	NAD binding
C	0070403	molecular_function	NAD+ binding
D	0017136	molecular_function	histone deacetylase activity, NAD-dependent
D	0051287	molecular_function	NAD binding
D	0070403	molecular_function	NAD+ binding
E	0017136	molecular_function	histone deacetylase activity, NAD-dependent
E	0051287	molecular_function	NAD binding
E	0070403	molecular_function	NAD+ binding
F	0017136	molecular_function	histone deacetylase activity, NAD-dependent
F	0051287	molecular_function	NAD binding
F	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2

Chain	Residue
A	CYS256
A	CYS259
A	CYS280
A	CYS283

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PGE A 400

Chain	Residue
A	HIS248
A	VAL292
A	GLY295

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 4

Chain	Residue
B	CYS280
B	CYS283
B	CYS256
B	CYS259

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 5

Chain	Residue
C	CYS256
C	CYS259
C	CYS280
C	CYS283

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 6

Chain	Residue
D	CYS256
D	CYS259
D	CYS280
D	CYS283

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 1

Chain	Residue
E	CYS256
E	CYS259
E	CYS280
E	CYS283

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 400

Chain	Residue
E	ARG135
E	LYS219
E	TRP379

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 3

Chain	Residue
F	CYS256
F	CYS259
F	CYS280
F	CYS283

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PGE F 400

Chain	Residue
F	HOH401

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12186850","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16788062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18794531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	162
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19535340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37720100","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19535340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8R104","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---