3GLI
Crystal Structure of the E. coli clamp loader bound to Primer-Template DNA and Psi Peptide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0003689 | molecular_function | DNA clamp loader activity |
A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
A | 0005515 | molecular_function | protein binding |
A | 0006260 | biological_process | DNA replication |
A | 0006261 | biological_process | DNA-templated DNA replication |
A | 0009360 | cellular_component | DNA polymerase III complex |
A | 0030894 | cellular_component | replisome |
A | 0043846 | cellular_component | DNA polymerase III, clamp loader complex |
A | 0071897 | biological_process | DNA biosynthetic process |
B | 0003677 | molecular_function | DNA binding |
B | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006260 | biological_process | DNA replication |
B | 0009360 | cellular_component | DNA polymerase III complex |
B | 0016887 | molecular_function | ATP hydrolysis activity |
C | 0003677 | molecular_function | DNA binding |
C | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0006260 | biological_process | DNA replication |
C | 0009360 | cellular_component | DNA polymerase III complex |
C | 0016887 | molecular_function | ATP hydrolysis activity |
D | 0003677 | molecular_function | DNA binding |
D | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
D | 0005524 | molecular_function | ATP binding |
D | 0006260 | biological_process | DNA replication |
D | 0009360 | cellular_component | DNA polymerase III complex |
D | 0016887 | molecular_function | ATP hydrolysis activity |
E | 0003677 | molecular_function | DNA binding |
E | 0003689 | molecular_function | DNA clamp loader activity |
E | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
E | 0005515 | molecular_function | protein binding |
E | 0006260 | biological_process | DNA replication |
E | 0006261 | biological_process | DNA-templated DNA replication |
E | 0008408 | molecular_function | 3'-5' exonuclease activity |
E | 0009360 | cellular_component | DNA polymerase III complex |
E | 0030894 | cellular_component | replisome |
E | 0043846 | cellular_component | DNA polymerase III, clamp loader complex |
E | 0071897 | biological_process | DNA biosynthetic process |
F | 0003677 | molecular_function | DNA binding |
F | 0003689 | molecular_function | DNA clamp loader activity |
F | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
F | 0005515 | molecular_function | protein binding |
F | 0006260 | biological_process | DNA replication |
F | 0006261 | biological_process | DNA-templated DNA replication |
F | 0009360 | cellular_component | DNA polymerase III complex |
F | 0030894 | cellular_component | replisome |
F | 0043846 | cellular_component | DNA polymerase III, clamp loader complex |
F | 0071897 | biological_process | DNA biosynthetic process |
G | 0003677 | molecular_function | DNA binding |
G | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
G | 0005524 | molecular_function | ATP binding |
G | 0006260 | biological_process | DNA replication |
G | 0009360 | cellular_component | DNA polymerase III complex |
G | 0016887 | molecular_function | ATP hydrolysis activity |
H | 0003677 | molecular_function | DNA binding |
H | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
H | 0005524 | molecular_function | ATP binding |
H | 0006260 | biological_process | DNA replication |
H | 0009360 | cellular_component | DNA polymerase III complex |
H | 0016887 | molecular_function | ATP hydrolysis activity |
I | 0003677 | molecular_function | DNA binding |
I | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
I | 0005524 | molecular_function | ATP binding |
I | 0006260 | biological_process | DNA replication |
I | 0009360 | cellular_component | DNA polymerase III complex |
I | 0016887 | molecular_function | ATP hydrolysis activity |
J | 0003677 | molecular_function | DNA binding |
J | 0003689 | molecular_function | DNA clamp loader activity |
J | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
J | 0005515 | molecular_function | protein binding |
J | 0006260 | biological_process | DNA replication |
J | 0006261 | biological_process | DNA-templated DNA replication |
J | 0008408 | molecular_function | 3'-5' exonuclease activity |
J | 0009360 | cellular_component | DNA polymerase III complex |
J | 0030894 | cellular_component | replisome |
J | 0043846 | cellular_component | DNA polymerase III, clamp loader complex |
J | 0071897 | biological_process | DNA biosynthetic process |
O | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
O | 0006260 | biological_process | DNA replication |
O | 0008408 | molecular_function | 3'-5' exonuclease activity |
P | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
P | 0006260 | biological_process | DNA replication |
P | 0008408 | molecular_function | 3'-5' exonuclease activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE ADP B 400 |
Chain | Residue |
B | ALA7 |
B | LYS51 |
B | THR52 |
B | SER53 |
B | LEU214 |
B | ARG215 |
B | LEU218 |
B | BEF401 |
B | MG412 |
C | GLU144 |
B | TRP10 |
B | ARG11 |
B | PRO12 |
B | VAL18 |
B | VAL19 |
B | GLY48 |
B | VAL49 |
B | GLY50 |
site_id | AC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE BEF B 401 |
Chain | Residue |
B | ARG47 |
B | GLY48 |
B | LYS51 |
B | GLU127 |
B | THR157 |
B | ARG215 |
B | ADP400 |
B | MG412 |
C | GLU144 |
C | ARG169 |
site_id | AC3 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE ADP C 402 |
Chain | Residue |
C | ALA7 |
C | TRP10 |
C | ARG11 |
C | PRO12 |
C | VAL18 |
C | VAL19 |
C | GLY48 |
C | VAL49 |
C | GLY50 |
C | LYS51 |
C | THR52 |
C | SER53 |
C | ARG215 |
C | LEU218 |
C | BEF403 |
C | MG413 |
D | GLU144 |
site_id | AC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE BEF C 403 |
Chain | Residue |
C | ARG47 |
C | LYS51 |
C | THR52 |
C | GLU127 |
C | ARG215 |
C | ADP402 |
C | MG413 |
D | THR165 |
D | ARG169 |
site_id | AC5 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE ADP D 404 |
Chain | Residue |
D | ALA7 |
D | ARG11 |
D | PRO12 |
D | VAL18 |
D | VAL19 |
D | GLY48 |
D | VAL49 |
D | GLY50 |
D | LYS51 |
D | THR52 |
D | SER53 |
D | LEU214 |
D | ARG215 |
D | LEU218 |
D | BEF405 |
D | MG414 |
E | GLU133 |
site_id | AC6 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE BEF D 405 |
Chain | Residue |
D | ARG47 |
D | GLY48 |
D | LYS51 |
D | GLU127 |
D | ARG215 |
D | ADP404 |
D | MG414 |
E | THR154 |
E | ARG158 |
site_id | AC7 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE ADP G 406 |
Chain | Residue |
G | ALA7 |
G | TRP10 |
G | ARG11 |
G | PRO12 |
G | VAL18 |
G | VAL19 |
G | GLY48 |
G | VAL49 |
G | GLY50 |
G | LYS51 |
G | THR52 |
G | SER53 |
G | LEU214 |
G | ARG215 |
G | LEU218 |
G | BEF407 |
G | MG415 |
H | GLU144 |
site_id | AC8 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE BEF G 407 |
Chain | Residue |
G | GLY48 |
G | LYS51 |
G | GLU127 |
G | THR157 |
G | ARG215 |
G | ADP406 |
G | MG415 |
H | GLU144 |
H | ARG169 |
G | ARG47 |
site_id | AC9 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE ADP H 408 |
Chain | Residue |
H | ALA7 |
H | TRP10 |
H | ARG11 |
H | PRO12 |
H | VAL18 |
H | VAL19 |
H | GLY48 |
H | VAL49 |
H | GLY50 |
H | LYS51 |
H | THR52 |
H | SER53 |
H | ARG215 |
H | LEU218 |
H | BEF409 |
H | MG416 |
I | GLU144 |
site_id | BC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE BEF H 409 |
Chain | Residue |
H | ARG47 |
H | LYS51 |
H | THR52 |
H | GLU127 |
H | THR157 |
H | ARG215 |
H | ADP408 |
H | MG416 |
I | THR165 |
I | ARG169 |
site_id | BC2 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE ADP I 410 |
Chain | Residue |
I | ALA7 |
I | TRP10 |
I | ARG11 |
I | PRO12 |
I | VAL18 |
I | VAL19 |
I | GLY48 |
I | VAL49 |
I | GLY50 |
I | LYS51 |
I | THR52 |
I | SER53 |
I | LEU214 |
I | ARG215 |
I | LEU218 |
I | BEF411 |
I | MG417 |
J | GLU133 |
site_id | BC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE BEF I 411 |
Chain | Residue |
I | ARG47 |
I | GLY48 |
I | LYS51 |
I | GLU127 |
I | ARG215 |
I | ADP410 |
I | MG417 |
J | THR154 |
J | ARG158 |
site_id | BC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG B 412 |
Chain | Residue |
B | THR52 |
B | ASP126 |
B | GLU127 |
B | ADP400 |
B | BEF401 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 413 |
Chain | Residue |
C | THR52 |
C | ASP126 |
C | GLU127 |
C | ADP402 |
C | BEF403 |
D | ARG169 |
site_id | BC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG D 414 |
Chain | Residue |
D | THR52 |
D | ASP126 |
D | GLU127 |
D | ADP404 |
D | BEF405 |
E | ARG158 |
site_id | BC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG G 415 |
Chain | Residue |
G | THR52 |
G | ASP126 |
G | GLU127 |
G | ADP406 |
G | BEF407 |
site_id | BC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG H 416 |
Chain | Residue |
H | THR52 |
H | ASP126 |
H | GLU127 |
H | ADP408 |
H | BEF409 |
I | ARG169 |
site_id | BC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG I 417 |
Chain | Residue |
I | THR52 |
I | ASP126 |
I | GLU127 |
I | ADP410 |
I | BEF411 |
J | GLU133 |
J | ARG158 |
site_id | CC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN B 418 |
Chain | Residue |
B | CYS64 |
B | CYS73 |
B | GLY74 |
B | CYS76 |
B | CYS79 |
site_id | CC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 419 |
Chain | Residue |
C | CYS64 |
C | CYS73 |
C | CYS76 |
C | CYS79 |
site_id | CC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN D 420 |
Chain | Residue |
D | CYS64 |
D | CYS73 |
D | GLY74 |
D | CYS76 |
D | CYS79 |
site_id | CC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN E 421 |
Chain | Residue |
E | CYS50 |
E | CYS59 |
E | CYS62 |
E | CYS65 |
site_id | CC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN G 422 |
Chain | Residue |
G | CYS64 |
G | CYS73 |
G | GLY74 |
G | CYS76 |
G | CYS79 |
site_id | CC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN H 423 |
Chain | Residue |
H | CYS64 |
H | CYS73 |
H | CYS76 |
H | CYS79 |
site_id | CC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN I 424 |
Chain | Residue |
I | CYS64 |
I | CYS73 |
I | GLY74 |
I | CYS76 |
I | CYS79 |
site_id | CC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN J 425 |
Chain | Residue |
J | CYS50 |
J | CYS59 |
J | CYS62 |
J | CYS65 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000255 |
Chain | Residue | Details |
B | GLY45 | |
C | GLY45 | |
D | GLY45 | |
G | GLY45 | |
H | GLY45 | |
I | GLY45 |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11525729, ECO:0007744|PDB:1JR3 |
Chain | Residue | Details |
B | CYS64 | |
D | CYS73 | |
D | CYS76 | |
D | CYS79 | |
G | CYS64 | |
G | CYS73 | |
G | CYS76 | |
G | CYS79 | |
H | CYS64 | |
H | CYS73 | |
H | CYS76 | |
B | CYS73 | |
H | CYS79 | |
I | CYS64 | |
I | CYS73 | |
I | CYS76 | |
I | CYS79 | |
B | CYS76 | |
B | CYS79 | |
C | CYS64 | |
C | CYS73 | |
C | CYS76 | |
C | CYS79 | |
D | CYS64 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
B | VAL253 |
site_id | CSA10 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
G | ARG215 | |
G | LYS51 | |
G | LYS141 |
site_id | CSA11 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
H | ARG215 | |
H | LYS51 | |
H | LYS141 |
site_id | CSA12 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
I | ARG215 | |
I | LYS51 | |
I | LYS141 |
site_id | CSA13 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
B | ARG215 | |
B | THR157 |
site_id | CSA14 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
C | ARG215 | |
C | THR157 |
site_id | CSA15 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
D | ARG215 | |
D | THR157 |
site_id | CSA16 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
G | ARG215 | |
G | THR157 |
site_id | CSA17 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
H | ARG215 | |
H | THR157 |
site_id | CSA18 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
I | ARG215 | |
I | THR157 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
C | VAL253 |
site_id | CSA3 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
D | VAL253 |
site_id | CSA4 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
G | VAL253 |
site_id | CSA5 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
H | VAL253 |
site_id | CSA6 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
I | VAL253 |
site_id | CSA7 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
B | ARG215 | |
B | LYS51 | |
B | LYS141 |
site_id | CSA8 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
C | ARG215 | |
C | LYS51 | |
C | LYS141 |
site_id | CSA9 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1g8p |
Chain | Residue | Details |
D | ARG215 | |
D | LYS51 | |
D | LYS141 |