3GH8

Crystal structure of Mus musculus iodotyrosine deiodinase (IYD) bound to FMN and di-iodotyrosine (DIT)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
B	0016491	molecular_function	oxidoreductase activity
C	0016491	molecular_function	oxidoreductase activity
D	0016491	molecular_function	oxidoreductase activity
E	0016491	molecular_function	oxidoreductase activity
F	0016491	molecular_function	oxidoreductase activity
G	0016491	molecular_function	oxidoreductase activity
H	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE FMN A 301

Chain	Residue
A	ARG96
A	TYI302
B	PRO123
B	SER124
B	GLY125
B	HIS127
B	SER212
B	HOH497
A	ARG97
A	SER98
A	ARG100
A	VAL232
A	THR233
A	THR234
A	THR235
A	ARG275

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TYI A 302

Chain	Residue
A	ARG100
A	GLU153
A	TYR157
A	LEU169
A	LEU172
A	ASN175
A	LYS178
A	HOH295
A	FMN301
B	GLY125
B	ALA126
B	TYR208

---

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE FMN B 301

Chain	Residue
A	PRO123
A	SER124
A	GLY125
A	HIS127
A	ILE211
B	ARG96
B	ARG97
B	SER98
B	ARG100
B	LEU172
B	VAL232
B	THR233
B	THR235
B	ARG275
B	HOH292
B	HOH300
B	TYI302
B	HOH434

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TYI B 302

Chain	Residue
A	ALA126
A	TYR208
B	ARG100
B	GLU153
B	TYR157
B	MET161
B	LEU169
B	LEU172
B	THR174
B	LYS178
B	THR235
B	FMN301

---

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE FMN C 301

Chain	Residue
C	ARG96
C	ARG97
C	SER98
C	ARG100
C	VAL232
C	THR233
C	THR235
C	ARG275
C	TYI302
C	HOH350
C	HOH383
D	PRO123
D	SER124
D	GLY125
D	HIS127

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TYI C 302

Chain	Residue
C	ARG100
C	GLU153
C	TYR157
C	LEU169
C	LEU172
C	THR174
C	LYS178
C	THR235
C	FMN301
D	GLY125
D	ALA126
D	TYR207

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 C 1

Chain	Residue
C	TYR207
C	TYR208
D	TRP165

---

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE FMN D 301

Chain	Residue
D	THR235
D	ARG275
D	TYI302
C	PRO123
C	SER124
C	GLY125
C	HIS127
D	ARG96
D	ARG97
D	SER98
D	ARG100
D	VAL232
D	THR233
D	THR234

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TYI D 302

Chain	Residue
C	ALA126
D	ARG100
D	GLU153
D	TYR157
D	MET161
D	LEU169
D	LEU172
D	LYS178
D	THR235
D	FMN301

---

site_id	BC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE FMN E 301

Chain	Residue
E	ARG96
E	ARG97
E	SER98
E	ARG100
E	THR233
E	THR234
E	THR235
E	TYI302
F	PRO123
F	SER124
F	GLY125
F	HIS127
F	TYR208

---

site_id	BC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TYI E 302

Chain	Residue
E	ARG100
E	GLU153
E	TYR157
E	TRP165
E	LEU169
E	LYS178
E	FMN301
E	HOH499
F	GLY125
F	ALA126

---

site_id	BC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE FMN F 301

Chain	Residue
E	PRO123
E	SER124
E	GLY125
E	HIS127
E	TYR208
F	HOH20
F	ARG96
F	ARG97
F	SER98
F	ARG100
F	VAL232
F	THR233
F	THR234
F	THR235
F	ARG275
F	TYI302
F	HOH379
F	HOH423

---

site_id	BC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TYI F 302

Chain	Residue
E	ALA126
E	TYR207
E	TYR208
F	ARG100
F	GLU153
F	TYR157
F	MET161
F	LEU169
F	LEU172
F	THR174
F	LYS178
F	THR235
F	FMN301

---

site_id	BC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE FMN G 301

Chain	Residue
G	HOH19
G	ARG96
G	ARG97
G	SER98
G	ARG100
G	LEU172
G	VAL232
G	THR233
G	THR234
G	THR235
G	ARG275
G	TYI302
G	HOH488
H	PRO123
H	SER124
H	GLY125
H	HIS127
H	ILE211

---

site_id	BC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TYI G 302

Chain	Residue
G	ARG100
G	GLU153
G	TYR157
G	LEU169
G	THR174
G	ASN175
G	LYS178
G	THR235
G	FMN301
H	ALA126
H	TYR207

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 G 2

Chain	Residue
G	TYR207
G	TYR208
H	TRP165

---

site_id	BC8
Number of Residues	19
Details	BINDING SITE FOR RESIDUE FMN H 301

Chain	Residue
G	PRO123
G	SER124
G	GLY125
G	ALA126
G	HIS127
G	TYR208
G	SER212
H	ARG96
H	ARG97
H	SER98
H	ARG100
H	VAL232
H	THR233
H	THR234
H	THR235
H	ARG275
H	TYI302
H	HOH396
H	HOH457

---

site_id	BC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE TYI H 302

Chain	Residue
G	GLY125
G	ALA126
H	ARG100
H	GLU153
H	TYR157
H	MET161
H	LEU169
H	LEU172
H	ASN175
H	LYS178
H	THR235
H	FMN301
H	HOH375
H	HOH396

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19436071","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22238141","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GB5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GH8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PDB","id":"3GFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TNZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19436071","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22238141","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TNZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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