3GB6
Structure of Giardia fructose-1,6-biphosphate aldolase D83A mutant in complex with fructose-1,6-bisphosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016832 | molecular_function | aldehyde-lyase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016832 | molecular_function | aldehyde-lyase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 326 |
| Chain | Residue |
| A | ALA83 |
| A | HIS84 |
| A | HIS210 |
| A | ASN253 |
| A | P6F327 |
| A | ZN330 |
| site_id | AC2 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE P6F A 327 |
| Chain | Residue |
| A | HIS178 |
| A | GLY179 |
| A | LYS182 |
| A | HIS210 |
| A | GLY211 |
| A | SER212 |
| A | SER213 |
| A | ASN253 |
| A | VAL254 |
| A | ASP255 |
| A | SER256 |
| A | ARG259 |
| A | ZN326 |
| A | ZN330 |
| A | HOH371 |
| A | HOH403 |
| A | HOH436 |
| A | HOH449 |
| A | HOH471 |
| A | HOH525 |
| A | HOH553 |
| A | HOH611 |
| B | ARG280 |
| A | ASN24 |
| A | GLN48 |
| A | SER50 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 330 |
| Chain | Residue |
| A | HIS84 |
| A | HIS178 |
| A | HIS210 |
| A | ZN326 |
| A | P6F327 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 328 |
| Chain | Residue |
| B | ALA83 |
| B | HIS84 |
| B | HIS210 |
| B | P6F329 |
| B | ZN331 |
| site_id | AC5 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE P6F B 329 |
| Chain | Residue |
| A | ARG280 |
| B | ASN24 |
| B | GLN48 |
| B | SER50 |
| B | HIS178 |
| B | GLY179 |
| B | LYS182 |
| B | HIS210 |
| B | GLY211 |
| B | SER212 |
| B | SER213 |
| B | ASN253 |
| B | ASP255 |
| B | SER256 |
| B | ARG259 |
| B | ZN328 |
| B | ZN331 |
| B | HOH382 |
| B | HOH413 |
| B | HOH447 |
| B | HOH461 |
| B | HOH468 |
| B | HOH534 |
| B | HOH545 |
| B | HOH568 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 331 |
| Chain | Residue |
| B | HIS84 |
| B | HIS178 |
| B | HIS210 |
| B | ZN328 |
| B | P6F329 |
Functional Information from PROSITE/UniProt
| site_id | PS00806 |
| Number of Residues | 12 |
| Details | ALDOLASE_CLASS_II_2 Fructose-bisphosphate aldolase class-II signature 2. VEaELGtlGGiE |
| Chain | Residue | Details |
| A | VAL132-GLU143 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"19236002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17166851","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19236002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17166851","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19236002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21333622","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ISV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ISW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GAK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GB6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OHI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
